Posted by admin on Jan 1, 2013 in |
In this study, an attempt was made to assess the physicochemical equivalence of four brands of Erythromycin stearate tablets marketed in Addis Ababa. Identity, weight uniformity, disintegration, dissolution and assay for the content of active ingredients were evaluated using the methods described in the British Pharmacopoeia 2007. All the samples passed the identity, disintegration, and dissolution tests but Erythromycin stearate (Produced in Sudan by General Medicines Company) failed to release 80% of the drug content within 45 minutes. It also failed to fulfill the tolerance limits for assay stipulated in the pharmacopoeia. This product therefore does not comply with the BP 2007 dissolution and Assay tolerance limits. This work revealed that the four products included in the study complied with the physicochemical quality parameters except Erythromycin stearate which failed to meet the pharmacopoeial specification for dissolution test and...
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Posted by admin on Jan 1, 2013 in |
Aim and Objectives: Fruit juice of Lagenaria siceraria (LS) belonging to Cucurbitaceae family, has been used traditionally to treat jaundice and to cure certain liver disorders. Antioxidants are well known for their hepatoprotective effect and in curing liver disorders. In this study, hepatoprotective and antioxidant effects of fruits were investigated. Materials and Methods: The coarsely powdered plant material was extracted successively with petroleum ether (PE) and ethanol (ETH) using soxhlet. PE & ETH, were then evaluated for their hepatoprotective and antioxidant activities against paracetamol induced hepatotoxicity and different in vitro assays respectively. Hepatoprotective activity was evaluated at three oral dose levels of 250, 500 and 1000 mg/kg. Results: Both extracts, PE and ETH exhibited a significant hepatoprotective and antioxidant activity. The ETH (1000 mg/kg) showed maximum hepato-protection. ETH also showed better antioxidant activity, in comparison to PE, in all the antioxidant assays. Conclusions: ETH has shown better hepatoprotective activity than PE, which could be due to its better antioxidant activity. Moreover, better activity can also be attributed to the...
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Posted by admin on Jan 1, 2013 in |
HIV since its invention has become global burden. In last two decades of the HIV prevalence many anti-retroviral drugs have been developed. Poor countries like India have started central government funded programmes to tackle the menace of the HIV. These programmes have been started because many people cannot afford costly ART drugs. In this review article, we have discussed current ART regimens and the new drugs which have been introduced. Also we have discussed traditional systems of medicine which are practised in India and their potential use in the HIV...
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Posted by admin on Jan 1, 2013 in |
The present study was designed to investigate the antihyperglycemic activity of chitosan of Podophthalmus vigil on normal and streptozotocin (STZ) diabetic rats. Diabetes was induced into male albino wistar rats by intraperitonial administration of STZ. Chitosan was administered orally at three different doses to normal and STZ-diabetic rats for 30 days. The diabetic rats showed an increase in levels of blood glucose and glycosylated hemoglobin (HbA1c) and a decrease in the levels of insulin and hemoglobin addition, diabetic rats showed a significant reduction in the activity of glucokinase and an elevation in the activities of gluconeogenic enzymes such as glucose-6-phosphatase and fructose-1, 6-bisphosphatase. Treatment with chitosan significantly decreased plasma glucose and HbA1c, and increased the insulin and Hb. Chitosan administration to diabetic rats reversed these enzyme activities in a significant manner. Thus, the results show that chitosan possesses an antihyperglycemic activity in the control of diabetes. The 300 mg dose of the extract produced a better effect than 100 and 200 mg...
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Posted by admin on Jan 1, 2013 in |
Administration of ethanol extract of Polygala chinensis whole plant (100 mg/kg and 200 mg/kg body weight) to alloxan induced diabetic rats for 14 days reduced the elevated level of lipid peroxidation (LPO). The treatment also resulted in significant increase in reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) in serum, liver and kidney. The results confirm the antioxidant activity of P. chinensis whole plant and suggest that because of its antioxidant effects its administration may be useful in controlling the diabetic complications in experimental diabetic...
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