Posted by admin on Nov 1, 2012 in |
The aim of this study was to investigate the possibility of gastric-ulceration by ginger-juice (Zingiber officinale Roscoe) in rat. (A) Albino rats (n=6-12) were administered G.J at two doses (2ml & 4 ml/rat, p.o) as single administration and chronic treatment over period of 30 days. Following this assessment was done for possible gastric lesion. Effect of treatment with G.J acutely and chronically (30 days) administered, was assessed. Parameters used during assessment were total acidity, gastric volume & pH and ulcer index ‘UI’ (acute and chronic). Acute & chronic administration of G.J (2ml & 4ml/rat, p.o) caused an increase in pH and vol. of gastric content, a decrease in total acidity and no significant change in ulcer...
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Posted by admin on Nov 1, 2012 in |
Waste is anything, which is not used by any owner, producer and processor, even though it has always been a part of the earth’s ecosystem. Enriched Soil is a good source for the isolation of power full and potential microorganisms which produces specific enzymes which target the waste and in turn produces pharmacologically viable products; Microbes hold this prominent position because of their diversity and proven ability to produce new enzymes which is capable of degrading the waste from various industries. In this study we have concentrated on Fruit, coconut, leather, poultry, and paper industrial waste. Vellore is a Industrial developing medium city surrounded by three states Andhrapradesh ,Tamilnadu and Karnataka and the soils are highly enriched with industrial waste the studies in this direction is rudimentary and hence this study proves the pivotal role on enriched soils in screening of potential microbial enzymes which are used in various pharmacy...
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Posted by admin on Nov 1, 2012 in |
Aim: The aims of this study were to develop liposome enriched Dexibuprofen liposomal hydrogels for topical delivery, perform in vitro release studies and in vivo permeation studies through mice/rat skin, and evaluate the efficacy of liposomal gels against inflammation induced rats. The purpose was to provide the delivery of the topical drug at a sustained rate across intact skin to improve bioavailability and inflammation control for longer period from liposomal gels. Method: Phosphatidylcholine, Cholesterol and Dexibuprofen were dissolved in chloroform/methanol (2:1, v/v) mixture and subsequently transferred into a pear-shaped flask connected to a Rotavapor (Büchi- type). Rotary evaporation method was used for the formulation of liposomes. Result: liposome prepared was evaluated for particle size measurement, percent drug entrapment, diffusion study, skin permeation study and in vivo study. F-7 batch found to be optimized batch having particle size 5.40 µm, % drug entrapment 61.70, % CDR 75.35 %. Hence F-7 batch further evaluated for skin permeation study, skin deposition study, in vivo study and stability study. Conclusion: The present study...
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Posted by admin on Nov 1, 2012 in |
The objective of this study is to evaluate the analgesic and anti-inflammatory activities of the Caesalpinia bonducella in animals. The analgesic action was evaluated in rats using the acetic acid-induced writhing test and the hot-plate test. The anti-inflammatory activity was estimated using carrageenan-induced paw edema in rats. Caesalpinia bonducella strikingly and dose-dependently suppressed carrageenan-elicited paw edema in rats, inhibited the writhing response in rats, increased reaction time of in the hot-plate test. These findings propose that aqua of Caesalpinia bonducella seed has evident non-central analgesic and anti-inflammatory...
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Posted by admin on Nov 1, 2012 in |
The present study deals with the antibacterial activity of Acetone, Dichloromethane, methanol extracts of the tuber and seed of Gloriosa superba L. (Liliaceae) using disc diffusion method against human pathogens, such as Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeurognisoa, Staphylocuccus aureus. In the present investigation all the extracts were found to be effective against five human bacterial species. The Dichloromethane extract showed greater activity against Proteus...
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