Posted by admin on Dec 1, 2012 in |
Background: Abortion is the termination of a pregnancy by the expulsion of a fetus or embryo from the uterus. Induced abortion is usually defined as deliberate pregnancy termination prior to 20 weeks (for developed countries) and 28weeks (for developing countries) gestation. Describing the determinants of induced abortions contributes for long lasting reduction of induced abortion. Objective: The aim of this study was to describe determinants of induced abortion among women of child bearing age, which experienced abortion, attending maternal and child health clinic in Mekelle town, Ethiopia. Method: Institutional based cross sectional study was employed and 260 study subjects were selected using convenient sampling technique, and the data was collected using interviewer administered structured questionnaire; data was analyzed and cleaned using SPSS version 16. Binary logistic regression analysis was carried out to see determination of variables. Results: Majority of women who had experienced induced abortion 138 (53.1%) were under the age of 25 years, with mean age 26.22 ±7.01years. A large number, 105 (40.4%) were with secondary school and...
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Posted by admin on Dec 1, 2012 in |
Chronic Obstructive Pulmonary Diseases (COPD) refers to multiple lung diseases, is the occurrence of chronic bronchitis and emphysema, a pair of commonly co-existing diseases of the lungs in which the airways become narrowed because of inflammatory cells like neutrophils, CD8 cells and macrophages. These cells produce the Matrix metalloproteinases (MMPs), cathapsins and other proteinase enzymes. In humans there are 26 MMPs are present, which are classified in to six categories based on the structure of their substrate, sequence similarity and characteristics of structural domain. Structurally, MMPs are similar, but functionally different – but the general function of MMP is to degrade the extracellular matrix according their specific substrates. From the literature, three MMPs [MMP-09, MMP-12 & MMP-14] which are implicated in COPD were selected. Our aim is was to achieve a meaningful understanding of selectivity of individual ligands towards their enzymes, while our interest also is to find explanations for selective and non-selective...
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Posted by admin on Dec 1, 2012 in |
Tadalafil (TD), a PDE-5 inhibitor, belongs to BCS class II. It is poorly soluble in water and requires enhancement in solubility and dissolution rate for increasing its oral bioavailability. In the present investigation, solid dispersed systems of tadalafil with poloxamer188 and sodium starch glycolate were prepared using solvent evaporation technique. The dissolution rate of the drug and poloxamer188 based solid dispersion was significantly higher than the sodium starch glycolate (SSG) based preparations and pure drug which reaches closer to the dissolution profile of marketed product. This was due to an increase in surface area of drug available for dissolution. Characterization of binary systems with FTIR studies demonstrated the presence of strong hydrogen bonding interactions, a significant decrease in crystallinity and the possibility of existence of amorphous entities of the drug. In the binary systems tested, 1:0.5 proportion of Tadalafil/poloxamer188 showed rapid dissolution of tadalafil (DE30 56.68 %). In the binary systems, tested (1:0.5) proportion of tadalafil/poloxamer188 showed rapid dissolution of tadalafil. In contrast, higher proportion of polaxmer188 (1:1) offered...
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Posted by admin on Dec 1, 2012 in |
Quinazolinone is a heterocyclic chemical compound. There are two structural isomers, 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common. The present survey aims to achieve the synthesis of quinazolinones and their derivatives of specific pharmacological properties. Various novel classes of structurally different quinazolinones have been designed and synthesized depicting potential interventions such as antibacterial, antifungal, antiviral, anticonvulsant, CNS depressant, anti-inflammatory, antihistaminic, anticancer and so on. At present some novel quinazolinone derivatives are synthesized and characterized by IR, H1 NMR, MASS Spectral...
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Posted by admin on Dec 1, 2012 in |
Background: Yerba mate (Ilex paraguariensis) is known to possess many biological activities against diverse tissues among others alimentary tract wall. Correspondence to Author: Dr. Roman Paduch Department of Virology and Immunology, Institute of Microbiology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19, 20-033 Lublin, Poland E-mail: rpaduch@poczta.umcs.lublin.pl Aim: The aims of the study were to evaluate potential toxic effects of water and ethanol (by Soxhlet extraction and shaking extraction methods) and free radical scavenging properties of Yerba mate extracts on human normal colonic epithelial and human colon carcinoma cells. Materials and methods: NR uptake, MTT, (DPPH.) reduction and ELISA tests were used to test toxicity, anti-proliferative activity, ROS reduction and cytokine level, respectively. Results: Depending on kind of extract, their concentration, kind of cells they influenced on and method of analysis, different toxic and stimulatory of cells viability effects were observed. Yerba mate extracts demonstrated strong free radical scavenging activity. The plant extracts also expressed immunomodulatory effects influencing on IL-6 production by normal and tumor cells. Ilex paraguariensis extracts stimulated...
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