Posted by admin on Oct 1, 2012 in |
Objective: Gestational diabetes mellitus is defined as “carbohydrate intolerance resulting in hyperglycemia of variable severity with onset or first recognition during pregnancy, whether or not insulin is used and regardless of whether diabetes persists after pregnancy. There is evidence that asymptomatic hyperglycemia during pregnancy leads to important morbidity in the mother and foetus. Hence, early detection and treatment of GDM will definitely reduce the complications and bring down the morbidity. Methods: Test was performed using 100 gm oral glucose. Blood samples were taken at 1hr, 2hr and 3hr as per standard protocol. Blood glucose was measured by glucose oxidase enzymatic method and all the values were tabulated and plotted on a graph. Interpretation was done using Carpenter and Coustan Criteria. Results: Out of the 96 women, 15 women were diagnosed as GDM. 5 out of them showed atypical pattern in OGTT curve. Similar such patterns were also seen in 5 normal subjects. Conclusion: In GDM with mild to moderate elevation in fasting plasma glucose, fasting plasma insulin is elevated...
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Posted by admin on Oct 1, 2012 in |
Background: Since prescribing is the first and foremost component in the process of using drugs, it is a vital element in rational drug use. The concept of rational prescribing requires that the prescriber follows correct and complete prescription writing. Objective: To assess prescribers adherence to the basic standards of prescription order writing in Serbo and Assendao health centers. Methodology: In this retrospective study, a total of 424 prescriptions were selected as a sample from the two health centers using systematic random sampling technique and data was collected using pre-tested format from January 3 to 28,2007. Result: In 3.3%, 4.7%, 70.8%, and 4.7%, 18.9%, 82.1% of the prescriptions, respectively, Age, Sex and card no of patients were not recorded. In 24.5%, 33% and 55.2%, 93.9% of the prescriptions date and signature of the prescriber were omitted, respectively. In 85% of the prescriptions, address of the patient was omitted in Serbo health center, but none of the prescriptions contained address of the patient in Assendabo health center. Out of the prescribed...
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Posted by admin on Oct 1, 2012 in |
In the present study, Polygala rosmarinifolia whole plant was extracted with ethanol and evaluated for anti-inflammatory activity in rats using a carrageenan induced paw edema method. Ethanol extract exhibits potent anti-inflammatory activity at 200mg/kg at 3rd hr after administration is compared with reference standard drug, Indomethacin. Observed pharmacological activity in the present study provides scientific validation of ethnomedicinal use of this plant in treating acute...
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Posted by admin on Oct 1, 2012 in |
The accumulation tendencies of different classes of compounds within the related Rutaceae genera and species are well documented, considering different populations and plant individuals. Aegle marmelos is one species which has been largely exploited in India in indigenous systems of medicine as a potential herbal medicine for abdominal disorders. The species has been listed as Vulnerable due to its destructive harvest. In this paper, the secondary metabolites of Aegle marmelos are compared with two other arboreal species, Feronia limonia and Chloroxylon sweitenia. This is an unexploited field of research in Natural Products and Pharmacology which offers great potential to identify species which can be used as substitutes or alternates in indigenous medicine. Use of alternate species requires further understanding of the pharmacology; however, a profiling of the compounds of the three species reveals that the chemical composition is almost similar, the other members having increased levels of the metabolites, in addition to newer compounds, suggesting their use as...
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Posted by admin on Oct 1, 2012 in |
The simple, accurate and precise HPTLC method was developed for quantification of curcumin content in dietary supplement formulation. In this method, individual curcuminoids (curcumin, demethoxy curcumin and bisdemethoxy curcumin) with piperine were resolved using mobile phase n-hexane: ethyl acetate: methanol: formic acid (8: 2: 1: 2-3 drops v/v) on a plate precoated with silica gel 60 F254 and quantified densitometrically in absorbance mode at 421 nm. The Rf value of curcumin was found to be 0.29. Linearity for curcumin was established between concentration range of 100-180 ng/spot with correlation coefficient of 0.999. The method was further validated as per ICH guidelines. The LOD and LOQ values for curcumin were found to be 27.3 ng and 82.7 ng respectively. The results of percent recovery and repeatability studies with standard deviation (≤2%), concluded that the developed method was accurate and precise and can be used for routine analysis of curcumin in dietary supplement...
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