Posted by admin on Sep 30, 2023 in |
Due to its similarity to the cell membrane seen in living organisms, gelatin is a natural biopolymer commonly used in tissue engineering applications. However, the rheological properties of gelatin formulations preclude their use in extrusion-based bioprinting. Using pectin as a viscosities modifier and formaldehyde for gelatin as a gelatin-pectin crosslinking agent, we offer a technique in the current work to improve the gelatin bioprinting capabilities. The primary goal of creating the gelatin-pectin formulation is to create a homogenous gelatin-pectin composite. Through defrost, microporous gelatin-pectin-formaldehyde sponges are produced, and their inborn characteristics, such as porosity, particle shape, degree of swelling, flexural modulus, and cell attachment examined. This is so that the crosslinking reaction may be completed when using formaldehyde, which calls for a drying phase. Rheological studies were conducted after...
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Posted by admin on Sep 30, 2023 in |
Introduction: Pharmacists have an integral role in the medication use process in performing interventions. In TTSH, accurate classification of interventions is important for supporting a learning culture within the hospital. Pharmacists spend at least 80 hours to look through 10,000 interventions monthly to ensure accurate classification. In recent years, artificial intelligence (AI) has been increasingly used in healthcare and may potentially be used to perform interventions classification. Aim: We aim to develop an intervention classification algorithm which can assist pharmacists in accurate classification of interventions. Pharmacists’ time spent can be reduced substantially and be better channeled to other higher leveled tasks to improve patient’s care. Methods: In designing the model for intervention classification algorithm, at least 80 000 pharmacist-checked intervention categories (PIC) were sent to Health Services & Outcomes Research, a division under the National Healthcare Group of Singapore (NHG). AI-predicted intervention categories (AIC) with a precision >90% matched PIC at least 95% of the time and exempted from manual pharmacists’ checking. Results: After utilization of the ML algorithm,...
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Posted by admin on Aug 31, 2023 in |
Scenedesmus dimorphus isone of the widely exploited microalgae in several arenas of science, such as in food, nutraceuticals, agriculture, and pharmaceutical industries due to its high nutritional content and bioactivities. The present study designed a novel, cost-effective, eco-friendly, easy-to-operate and rectangular photobioreactor using glass material. Photobioreactor was provided with monochromatic LED light of 3000, 5000, 10,000 and 15,000 lux, agitation, and aeration facility. The effect of inoculum concentration, pH, temperature, and light intensity on the growth of S. dimorphus was evaluated in a novel photobioreactor. Finally, to convert dairy waste into valuable bioresources, dairy waste’s effect on microalgae growth was investigated in an optimized condition using a novel photobioreactor. The optimum inoculum concentration to obtain the highest growth of S. dimorphus was 1-2×107 cells/ml in proteose peptone medium (pH 6.8) at 20ºC with photoperiodicity of Dark/Light (D/L) 12/12h and 12,000 lux.In similar experimental conditions, S. dimorphus revealed maximum growth at pH 7.0 and the optimum light intensity was 15,000lux.Growth temperature optimization in optimum conditions with D/L 12/12h indicated significant...
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Posted by admin on Aug 31, 2023 in |
Parkinson’s disease (PD) is the second most prevalent type of neurodegenerative disorder and is a chronic, progressive condition. In the current investigation, we used a rotenone (ROT)-developing rat model of PD to assess the neuroprotective efficacy of ethanolic Withania somnifera root extract (EWSR) in comparison to the known neuroprotectants i.e., Doxycycline (Doxy), and ellagic acid (EA) individually and in combination (EWSR-Doxy-EA). Male Wistar rats were given ROT at a dose of 2.5 mg/kg body weight daily for 4 weeks to develop a PD in-vivo model. Once the PD model is confirmed, the rats were treated with individual neuroprotectants for next 5 weeks and kept under observation for next 7 days for reversal of PD. ROT administration has altered behavioural parameters (Cognitive, motor dysfunction, sniffing, grooming, raring, crossing, etc.) and neurotransmitter profile (Acetylcholine, epinephrine, nor-epinephrine, dopamine, glutamate and aspartate) in rats. The administration of neuroprotectants has ameliorated the deleterious effects of rotenone and restored cognitive and motor control by rectifying the levels of neurotransmitters which are responsible for the functions....
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Posted by admin on Aug 31, 2023 in |
Objective: The study’s key objective is to evaluate the Antidiabetic activity of methanolic root extract of Daucus carota in normal, streptozotocin-induced Diabetic, and alloxan-induced diabetic rats. Materials and Methods: Albino Wistar rats were administered at a dose of streptozotocin 50mg/kg /day and alloxan monohydrate 150mg/kg/day i.p. for 30 days. Experimental rats were given Daucus carota root extract in two different doses of 200mg and 400mg/kg/day orally. Results: The Preliminary phytochemical investigation of Daucus carota shown that the presence of sterols, saponins, flavonoids, and triterpenoids. In this study, Daucus carota root extract was administered for 30 days and showed antidiabetic activity in STZ diabetic rats and alloxan-induced rats. Conclusion: The methanolic extract of Daucus carota roots also has potential antidiabetic activity in STZ-Nicotinamide diabetic rats. The extract also normalized the altered diabetic parameter viz. glycosylated hemoglobin, plasma cholesterol and glutathione. The decreased level of cholesterol indicates that the plant extract also has hypolipidemic...
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