Posted by admin on Dec 1, 2012 in |
A new spectrophotometric method is developed for the determination of artesunate (ARTS) in pharmaceutical preparation and bulk drug. The method involved heat-catalyzed derivatization of the drug with acetic anhydride and concentrated sulphuric acid producing a yellow coloured product peaking at 420.6 nm. The optimum conditions of the reaction and the analytical procedures of the assay were established. Under the optimum conditions, linear relationship with good correlation coefficient (0.9994) was found between the absorbance and the concentration of ARTS in the range of 4 – 60 µg mL-1. The limit of detection was found to be 0.72 µg mL-1 and quantitation limit was 1.8 µg mL-1. The analytical performance of the method was validated and the results were satisfactory. The developed method was successfully validated and applied for the determination of artesunate in bulk and pharmaceutical formulation without any interference from common...
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Posted by admin on Dec 1, 2012 in |
In the present study, an attempt has been made to formulate and evaluate orodispersible tablets of meclizine hydrochloride by using direct compression via employing different excipients in different ratio including: superdisintegrants {sodium starch glycolate (SSG), crosscarmellose sodium (CCS), crosspovidone (CP), and microcrystalline cellulose (MCC)} which were used alone and in combination, solid dispersion of MHCl in microcrystalline cellulose, diluents: lactose, granulated lactose, and mannitol, along with lubricant and glidants. The prepared formulas were evaluated for pre and post compression parameters including bulk density, tapped density, Carr’s index, angle of repose, weight variation, thickness, friability, hardness, in vitro disintegration and dispersion time, wetting time, and water absorption ratio. The formulas containing granulated lactose (as diluent) showed good flow properties. Increasing concentration of three superdisintegrants (CP, SSG, and CCS) was accompanied with an increase in disintegration time (DT) while the disintegration time was decreased with an increase in concentration of MCC. Depending on the obtained results, formula 11 (F11) which contains 4% W/W CP, 10% W/W MCC was selected as an...
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Posted by admin on Dec 1, 2012 in |
The kinetics of oxidation of amitriptyline by potassium permanganate in aqueous sulphuric acid medium at 298K and at a constant ionic strength of 0.20 mol dm-3 has been investigated spectrophotometrically. The reaction exhibits 5:4 stoichiometry (5 Amitriptyline:4 KMnO4). The reaction was first order with respect to manganese(VII) concentration. The order with respect to amitriptyline was found to be less than unity (0.80). Increase in acid concentration increased the rate. The order with respect to acid concentration was also less than unity (0.40). The effect of added products, ionic strength and dielectric constant has been studied on the rate of reaction. The oxidation products were identified by using 2, 4 DNP derivative, IR, GCMS spectral studies. A suitable mechanism was proposed on the basis of experimental results. The reaction constants involved in the different steps of the reaction mechanism were calculated. The activation parameters with respect to slow step of the mechanism was determined and...
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Posted by admin on Dec 1, 2012 in |
Cyperus rotundus Linn. (Cyperaceae) is an indigenous medicinal plant used for the treatment of pain, inflammation, diarrhoea, tumours, wounds and as Antidiabetic Anticonvulsant, Antimicrobial, Antiallergic, Antioxidant and Antiarthritic. The methanolic extract of rhizome was subjected to anti-inflammatory activity using experimental animal model of carrageenan induced paw edema in the presence of control for comparison. The results showed that methanolic extract significantly ameliorate oedema comparable to reference standard, Indomethacin. The results of this study explicate justification of the use of this plant in the treatment of inflammatory disease...
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Posted by admin on Dec 1, 2012 in |
Evolvulus aslsinoides is being used in traditional medicine for the treatment of severe bronchitis and asthma. So the aim of study was to evaluate antioxidant and antiasthmatic activity of ethanol extract of Evolvulus aslsinoides leaves. The present investigation was undertaken to evaluate the histamine-induced bronchospasm of alcoholic extract of Evolvulus aslsinoides leaves in experimental animals. Bronchodilator activity of aqueous extract of Evolvulus aslsinoides leaves studied on the histamine aerosol induced bronchospasm in wister rats. Treatment with alcoholic extract of Evolvulus aslsinoides leaves (250 mg/kg, p.o) showed significant protection against histamine aerosol induced bronchospasm in wister rats. The results of the histamine-induced bronchospasm paradigms demonstrate bronchospasmolytic activity of ethanolic extract of Evolvulus aslsinoides leaves (250 mg/kg, p.o.). Evolvulus aslsinoides leaves shows 41.49% protection against histamine induced bronchoconstriction in rats. These results suggest that aqueous extract of Evolvulus aslsinoides leaves has not only bronchodilating activity but also decreases bronchial hyperreactivity by decreasing the infiltration of inflammatory cells in the airway and inhibition of release of histamine like mediators from the mast cell...
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