Posted by admin on Nov 1, 2012 in |
A Simple, Fast and Reliable UV Derivative Spectrophotometric Method was developed and Quantitative Estimation of Metaxalone and Diclofenac potassium in Pharmaceutical Dosage Form was carried out using the First Derivative values measured at 276 nm for Metaxalone and 270 nm for Diclofenac potassium. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Metaxalone using 80-800 µg/ml and 10-100 µg/ml of Diclofenac potassium for First Derivative Spectrophotometric Method and the correlation coefficient was found to be 0.9986 and 0.9982 respectively. Precision study showed that the % RSD was within the range of acceptable limits (< 2), and the % Recovery was found to be in the range of 99-100% for Metaxalone and 100-101% for Diclofenac potassium. Developed Spectrophotometric Method in this study was Simple, Accurate, Precise, Specific, Sensitive, Reproducable and can be directly and easily applied to Pharmaceutical Dosage...
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Posted by admin on Nov 1, 2012 in |
The aim of this work is to determine the cytotoxic activities of Terminalia arjuna (Family: Combretaceae) by brine shrimp lethality bioassay. The leaves of Terminalia arjuna were extracted with methanol and the methanolic extract was fractionated into three fractions by using organic solvents like n-hexane, ethyl acetate and chloroform. The n-hexane, ethyl acetate and chloroform soluble fractions of methanolic crude extract were screened for antitumor properties using brine shrimp lethality bioassay. A reputed cytotoxic agent vincristine sulphate was used as a positive control. From the results of the brine shrimp lethality bioassay it could be well predicted that n- hexane, ethyl acetate and chloroform soluble fractions of Terminalia arjuna leaves possess cytotoxic principles (LC50 1.29 µg/mL, 1.5 µg/mL and 1.23 µg/mL respectively) comparison with positive control, vincristine sulphate (LC50 0.563...
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Posted by admin on Nov 1, 2012 in |
Povidone-Iodine Ointment was prepared using polyethylene glycol base by fusion method and the gel was prepared using Poloxamer 407 as a gelling agent by cold process. The different characteristics of povidone-iodine ointment and gel were compared from the results obtained for assay and total, available and complex iodine contents. These values were comparable with marketed formulations. The formulations were tested for wound healing and antimicrobial activity. Wound healing studies show that the time taken for complete wound healing was slightly less for prepared povidone-iodine ointment and gel than the marketed preparations. Antimicrobial activity also found to be almost equal for the different...
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Posted by admin on Nov 1, 2012 in |
Ofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone. Gastric emptying of dosage forms is an extremely variable process and ability to prolong and control the emptying time is a valuable asset for dosage forms, which reside in the stomach for a longer period of time than conventional dosage forms. Several difficulties are faced in designing controlled release systems for better absorption and enhanced bioavailability. To overcome the problem of conventional dosageforms ofloxacin effervescent floating tablets were developed in six different formulations (F1 to F6) by employing different grades of polymers and effervescent agent sodium bicarbonate. The formulations were evaluated for various physical parameters, buoyancy studies, dissolution parameters and drug release mechanisms. F6 formulation showed good physical parameters and gave slow and maximum drug release of ofloxacin spread over 24 hours and showed maximum similarity with marketed product in dissolution profile. Different kinetic models were applied to drug release data in order to evaluate release mechanisms and...
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Posted by admin on Nov 1, 2012 in |
Cayratia trifolia (Linn.) Domin (Vitaceae) is a perennial climber, commonly known as fox grape in English, Amalbel, Ramchana in Hindi and Amlavetash in Sanskrit, found in India, Asia and Australia. The infusion of seeds along with extract of tubers is used traditionally for the treatment of diabetes. Whole plant is used as diuretic, in tremors and splenopathy. It is reported to possess antiviral, antibacterial, antiprotozoal, hypoglycaemic, anticancer and diuretic activity etc. The present study was carried out to establish the pharmacognostical studies, physico-chemical parameters along with preliminary phytochemical screening of petroleum ether, chloroform, methanolic and aqueous extracts of Cayratia trifolia (Linn.) Domin. The macroscopical and microscopical characters were studied. The transverse section (T.S.) of stem indicated the arrangement of various cells in cork, cortex, phelloderm and pith region. The histochemical color reaction of T.S with different chemical reagents and preliminary phytochemical screening of various extracts revealed the presence of carbohydrate, flavonoids sterols, phenolic & tannins compounds. The physico-chemical parameters such as total, acid insoluble, water insoluble and sulphated ash...
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