Posted by admin on Sep 1, 2012 in |
It is important to predict the serum thyroid hormones level in females during infertility to prevent its occurrence later on. In this study, we studied serum thyroid hormones and menstrual irregularities during infertility. A case control study was performed in 75 infertile patients with menstrual irregularities and 50 healthy matched women. Three biochemical parameters were measured in serum, hormones triiodothyronine (T3), tetra-iodothyronine (T4) and serum thyroid stimulating hormone (TSH) by TOSOH-AIA-360, immunoassay method. Out of 75 infertile women sixteen percent (16%) had menstrual irregularities with hypothyroidism. The mean serum thyroid level in 75 infertile women were 0.88±0.34 ng/ml, 7.69±2.87 μIu/dl and 5.43±6.88 μIu/ml, respectively. Serum T3, T4 and TSH level were statistically highly significant in infertile women. Serum thyroid stimulating hormone level was found at higher side in infertile women. High incidence of hypothyroidism was found in infertile women and it shows a positive correlation with menstrual...
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Posted by admin on Sep 1, 2012 in |
Losartan potassium is an angiotention receptor antagonist, used in the management of hypertension. The objectiveof the proposed research work is to prepare and evaluate the mouth dissolving/disintegrating tablets (MDTs) of losartan Potassium, which avoid the first-pass metabolism, improved the dissolution rate and enhance the bioavailability. Mouth dissolving tablets (MDTs) were prepared by direct compression method by using combination of superdisintegrant like Ac-Di-Sol and Polyplasdone-xl (1%,2%,3%&4%) and evaluated for physico-chemical evaluation parameter such as hardness, friability, weight variation, drug content uniformity, water absorption ratio, wetting time, in-vitro and in-vivo disintegration time, in-vitro dissolution studies. The control tablet (without superdisintegrant) was formulated and evaluated. The twelve formulations, B1to B8 were formulated and among these formulations, B8 was optimized. The hardness, friability, weight variation and drug content were found to be within pharmacopeias limits. The water absorption ratio, wetting time, in-vitro and in-vivo disintegration time of optimized formulation, B8 was found to be 86.1%, 8secs, 18secs and 25secs respectively. The formulation, B8 was considered to best formulation, which released up to 99.21%...
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Posted by admin on Sep 1, 2012 in |
Diospyros melanoxylon is a medium-sized tree or shrub which belongs to the family Ebenaceae. The whole plant is medicinally important and cures several diseases. Therefore, in this context the detailed pharmacognostic study of various parts like leaf, stem, petiole and root has been carried out with the aim to establish its Pharmacognostical standards. The parameters selected were microscopical studies, proximate analysis, fluorescence analysis and preliminary phytochemical screening. The microscopical studies of leaf,stem and root revealed the presence of branched trichomes,spiral xylem vessel. In physicochemical evaluation the ash values and extractive values were studied. Fluorescence analysis performed showed the wide range of fluorescence colors for the crude powder. The Diospyros melanoxylon powder was successively extracted with hexane, benzene, chloroform, ethylacetate, ethanol and water for the identification of the best solvent. Preliminary phytochemical screening was carried out for all the extracts and maximum chemical constituents were observed in the ethanolic...
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Posted by admin on Sep 1, 2012 in |
This investigation describes a new precise, sensitive and accurate RP-HPLC method for the Simultaneous estimation of Sumatriptan succinate and Naproxen Sodium in Bulk and Tablets. The resolution of two drugs was achieved on XTerra C18 (150mm x 4.6mm i.d., 3.5mm particle size) column with UV detection at 284nm and the mobile phase consists of Buffer and Acetonitrile (25:75 v/v). Using chromatographic conditions described Sumatriptan succinate and Naproxen Sodium were well resolved with mean retention times of 2.622 and 4.070 min, respectively. Linear response (r>0.999) was observed over the range of 30-70µg/ml for Sumatriptan succinate and 20-60µg/ml for Naproxen Sodium. The lower limit of quantification and lower limit of detection was 10.02 and 3.0 for Sumatriptan succinate and 10.05 and 2.99 for Naproxen Sodium. The Validation parameters were performed according to the ICH guidelines and the proposed method can be useful in the routine analysis for the determination of Sumatriptan succinate and Naproxen Sodium in Pharmaceutical dosage...
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Posted by admin on Sep 1, 2012 in |
Trypsin inhibitor (AATI) was purified from the seeds of Achyranthes aspera to homogeneity by conventional methods and its antimicrobial activity was tested on selected pathogenic microbes. The inhibitor significantly affected the growth of Proteus vulgaris followed by Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Klebsiella pneumonia with zones of inhibition recorded as 28mm, 26mm, 25mm, 20mm and 14mm respectively. No inhibition, however, was observed with Staphylococcus pneumonia strain. Minimum inhibitory concentration (MIC) values of AATI supported that Proteus vulgaris and Bacillus subtilis were the most sensitive strains against the inhibitor. AATI did not differentiate gram positive and gram negative bacteria in its antibacterial activity. The trypsin inhibitor was ineffective against fungal strains Asperigillus niger, Fusarium oxysporum, Alternaria alternate and Candida albicans...
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