Posted by admin on Sep 1, 2012 in |
Thiazolidinediones (TZDs) were widely used for the treatment of type 2 diabetes. Recent studies have shown that TZDs have paradoxical effects on cardiovascular diseases. The objective of the present study was to investigate the effect of TZDs (Rosiglitazone and Pioglitazone) in High Fructose Diet (HFD) induced hypertension in rats. HFD was given for 14 weeks. After 8 weeks of hypertension induction period, treatment phase was started with Rosiglitazone (ROSI 10 and 30 mg/kg, p.o.) and Pioglitazone (PIO 10 and 30 mg/kg, p.o.) to the respective groups which were continued till 6 weeks. Systolic Blood Pressure (SBP) was measured weekly and serum glucose, triglyceride, cholesterol and HDL-C were measured at the end of study period. In HFD fed rats hypertension was observed after 8 weeks. Treatment with the test drugs significantly reversed the changes in serum enzyme levels as well as SBP made by HFD feeding compared to the control group. The study concludes that TZDs possess antihypertensive effect as exhibited in the present experimental...
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Posted by admin on Sep 1, 2012 in |
6-chloro 2, 4-diamino pyrimidine reacts with various aromatic aldehyde. Finally, the product was characterized by conventional and instrumental methods. Their structures were determined and important therapeutic properties were...
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Posted by admin on Sep 1, 2012 in |
The present study was undertaken to investigate in-vitro antioxidant activity of aqueous and hydroalcoholic extract of whole plant of Bacopa monnieri Linn. Family- Scrophularaceae. The total Phenolic content was determined using folin ciocalteau method while the total flavonoid content was determined using aluminium chloride method. In vitro antioxidant activity was evaluated using the Reducing power assay, Hydrogen peroxide scavenging assay, nitric oxide scavenging activity, superoxide scavenging activity and hydroxyl radical scavenging activity. The hydroalcoholic extract had more phenol concentration (116.1 mg/g of extract) when compared to aqueous extract (58 mg/g of extract). The flavonoid content was more in hydroalcoholic extract (242.6 mg/g of extract) when compared to that of aqueous extract (202.8 mg/g of extract). The reducing power and hydrogen peroxide scavenging of the extract was found to be concentration dependent. The nitric oxide scavenging activity, superoxide scavenging activity and Hydroxyl radical scavenging activity was also concentration dependent with IC50 value being 254.70 µg/ml , 934.06 µg/ml and 510.60 µg/ml respectively for Aqueous extract and 169.22 µg/ml, 495.83 µg/ml,...
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Posted by admin on Sep 1, 2012 in |
Tizanidine is a muscle relaxant agent, with the half life of 2.5 hours and requires daily doses to maintain adequate plasma concentrations. The present study was undertaken to with an aim to formulation development and evaluation of Tizanidine hydrochloride sustained release tablets using hydrophilic polymer to sustain the action of Tizanidine. Different batches of Tizanidine hydrochloride were prepared based on preformulation studies using HPMC K100M HPMC K4M and HPMC K100 having different viscosities to calculate the sustained release properties. Tizanidine hydrochloride was analysed by using HPLC using wavelength 240 nm. Results of in-vitro study indicate that the trial formulation 5 having considerable sustaining property. From the discussion it is concluded that the trial formulation 5 had considerable in-vitro drug release. Trial formulation 5 can be taken as an ideal or optimized formulation of sustained release tablets for 12 hours release and it fulfils all the requirements for...
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Posted by admin on Sep 1, 2012 in |
Objective: To determine the effect of amlodipine on blood glucose levels through oral glucose tolerance test in normoglycemic albino Rats and the magnitude of its effect on basal v/s glucose induced glycemic value compared to control. Methods: Rats were divided into control and test groups to study the effect of glucose induced glycemic changes in normal rats following oral administration of amlodipine. The control group received 1 ml of distilled water everyday, test group received amlodipine everyday in the dose of 1.5 mg/Kg BW for 3 days.On the third day, 2 hours after drug administration both groups were administered oral glucose in the dose of 0.6 gm/Kg BW. The blood glucose levels were measured at 0, 60 and 150 minutes after glucose administration by rat tail snipping method using ACCUCHEK glucometer. Results: The mean CBG of Test group is significantly higher(P<0.001) at all times of the glucose challenge i.e. 0, 60, 150 minutes from the time of glucose administration compared to control group. The optimal hyperglycemia was seen at...
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