Various 1-(substituted benzylidene)-5-(3-hydroxyquinoxaline-2-yl) carbonohydrazide were synthesized starting from orthophenylenediamine. Structures of all the compounds were confirmed on the basis of spectral analyses. All the newly synthesized compounds were screened for anticonvulsant activity. Some of the compounds showed significant anticonvulsant activity with no...
Read MoreThe purpose of this study was to investigate the experimentally possible antitumor effect and antioxidant role of methanolic extract of Tabebuia rosea leaves against Dalton’s ascetic lymphoma (DAL) induced Swiss albino mice. The methanolic extract of Tabebuia rosea (METR) was administered at the doses of 100mg/kg, 200mg/kg in mice for 14 days after 24hours of DAL inoculation. The effects of METR on the growth of bodyweight, MST, viable and nonviable cell count, Tumor volume, Packed Cell Volume (PCV), life span of DAL bearing mice were studied. Hematological profile and liver biochemical parameters (lipid per oxidation, antioxidant enzymes) were also estimated. Treatment with METR decreased the tumor volume and viable cell count thereby increasing the lifespan of DAL bearing mice. Alteration in the Hematological parameters, protein, PCV occurred because of DLA inoculation, were almost restored in METR treated groups. The effect of METR also decreases the levels of lipid peroxidation and increases the levels of glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT). The histopathological results showed the loss of...
Read MoreDevelopment of anthelmintic resistance and high cost of conventional anthelmintic drugs lead to the evaluation of medicinal plants which acts as an alternative source of anthelmintics. The present study has been undertaken to perform the evaluation of anthelmintic activity of Plumbago zeylanica belonging to family Plumbaginaceae. In the current study, experiments were conducted to evaluate the possible anthelminitic effects of various extracts of the roots of Plumbago zeylanica. Various concentrations (5, 10, 15, 20mg/ml) of water and methanol extracts were tested and results were expressed in terms of time for paralysis and time for death of worms. Piperazine citrate was taken as a reference standard drug.The anthelmintic activity was observed by gradually increasing the dose of extract. Methanolic extract of Plumbago zeylenica showed higher activity as compared to water...
Read MoreAlzheimer’s disease (AD) is characterized by the abnormal aggregation of amyloid ß (Aß) peptide into insoluble fibrils called amyloid plaques. Preventing this process of fibrillization may offer effective therapy for treatment of AD. The aim of the present study is to investigate the effect of methanolic extracts of 13 plant species which are known to be brain boosters in Ayurvedic system of medicine. Our study addressed the influence of these extracts on (i) prevention of aggregation of Aß and (ii) dissociation of preformed Aß fibrils. The aggregation status was monitored by thioflavin T fluorescence assay. The results showed that extracts from Bacopa monneria, Centella asiatica, Convolvulus pluricaulis, Withania sominfera, Nardostachys jatamansi and Glycirrhiza glabra exhibited promising activity by preventing Aß fibril formation/ retention thus identifying Aß as the molecular target for their action. These findings prompt further studies to isolate the active ingredients from these extracts to ultimately determine their therapeutic potential in AD...
Read MoreAn HPTLC method for estimation of Terbinafine hydrochloride in its tablet formulation has been developed. It employs aluminium backed silica gel 60 F254 TLC plates,( 100×50 mm, thickness of layer 0.2 mm), prewashed with methanol and dried at room temperature)and mobile phase comprising of Acetonitrile: 1, 4 dioxan: Hexane: Acetic acid (1:1:8:0.1) (v/v/v/v). The developing solvent was run upto 70 mm in Camag chamber. Densitometic scanning was then performed with Camag TLC scanner-3 at λmax 282 nm. The Rf value was found to be 0.45. The linearity and range for Terbinafine Hydrochloride was found to be 500-4500ng/spot. The method was validated for precision, accuracy and...
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