Posted by admin on Oct 1, 2012 in |
Excessive platelet activity is one of the most important factors responsible for the incidence of cardiovascular diseases and, also, play important role in coagulation cascade. In this study, the comparative effects of methanol extracts of three herbs on adhesion of the activated platelets to fibrinogen coated plates and clotting factors were investigated. Artemisia dracunculus, Punica granatum and Brberis vulgaris are used as blood anti-coagulatory plants in Iranian folk medicine. Platelets were prepared and incubated with different concentration of the test samples (50-200 μg/ml) for 60 min. The treated and un-treated platelets were then activated with thrombin (0.25U/ml) and their adhesions to fibrinogen coated plates were investigated. Based on obtained data, the methanol extract of Artemisia dracunculus, Brberis vulgaris and Punica granatum at a concentration of 200 μg /ml reduced platelet adhesion to coated wells by 35%, 25% and 20%, respectively. In addition, the effects of the crude extracts of each plant on atherogenic lipoproteins were also examined. The results indicated that the LDL and cholesterol concentration were dramatically reduced...
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Posted by admin on Oct 1, 2012 in |
A simple HPTLC method was used to determine the saponin profile of Barleria cristata L. crude leaf extract. The antimicrobial activity of saponin fraction from the leaves of Barleria cristata L. was studied in-vitro against four bacterial species and four fungal species by agar disc diffusion method. Klebsiella Pneumonia, Staphylococcus aureus, E. coli, Aspergillus parasites were the most inhibited microorganism. The present study suggests that the saponin fraction possess significant antimicrobial activity and can be used to develop a potential antimicrobial...
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Posted by admin on Oct 1, 2012 in |
Condensation reaction of 1, 4-phenylene diamine and Protochatechu aldehyde in 1:2 molar ratio resulted in the formation of new Schiff base ligand 4, 4–(1,4-phenylene bis(azan-1-yl-1-ylidene))bis(methan-1-yl-1-1-ylidene)-1, 2-diol; (H4L) .From the direct reaction of the ligand (1) with Co(II), Ni(II) and Cu(II) chlorides and Fe(III) and Zn(II)nitrates in 2M:1L molar ratio, the five new neutral complexes were prepared. The characterization of the newly formed compounds was done by 1HNMR, U.V-Vis and IR spectroscopy and elemental analysis. The data showed tetrahedral geometry for Co, Ni, Cu and Zn complexes (3, 4, 5 and 6 respectively) and octahedral geometry for Fe complex (2). The in-vitro antibacterial activity against G+ve bacteria (B. subtillus and S. aureus), G -ve bacteria (E. coli and P. aeruginosa) and antifungal activity against (C. albicans and A. niger) of the metal complexes were studied and compared with that of free ligand. Also MIC of the compounds against test microorganisms were...
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Posted by admin on Oct 1, 2012 in |
In developing countries, the majority of people living in rural areas almost exclusively use traditional medicines to treat all sorts of diseases including diarrhea. Many plants namely Andrographis paniculata, Acacia catechu, Acacia chandra, Terminalia chebula, Pterocarpus marsapium, Cassia auriculata etc. available in india are used in traditional folklore medicine for the treatment of diarrhea. Diarrhoea is a comman cause of illness resulting in high mortality in developing countries worldwide distribution of diarrhoea accounts for more than 5-8 millions deaths each year. It thus becomes important to identify and evaluate scientifically the antidiarrhoeal effects of leaves of Acorus calamus against castor oil induced dirrhoea. Methanolic Extract was studied for antidiarrhoeal potential using wistar rats and loperamide as a standard. Extracts were administered orally to test animals. Stools were collected upto 4 hrs in transparent plastic dishes of uniform weight. Urine was drained off by gravity every 15 mins. during the 4 hrs. diarrhoeal free period, acute diarrhoea and late diarrhoeal excretions were noted. Gastrointestinal motility test also performed. Methanolic extract...
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Posted by admin on Oct 1, 2012 in |
Stavudine an anti-retroviral drug is used for treating HIV now-a-days. The present approach aims to formulate an orally disintegrating tablet of stavudine for better patient compliance and bypassing the hepatic metabolism. In order to have an orally disintegrating tablet of stavudine, there is a need to mask the bitter taste. For the masking of bitter taste mannitol is used as taste masking agent. In the formulation of ODTs, a semi-synthetic super disintegrant sodium starch glycolate and a natural disintegrant, sodium alginate was used. Formulations F1, F2, F3, S1, S2 and S3 were evaluated for the required quality control tests.F3 and S3 were found to have a disintegration time of 7secs and 6secs, respectively. Upon observing the dissolution profiles and disintegration time of formulations, F3 and S3 showed good...
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