Posted by admin on Aug 1, 2012 in |
Aim: The aim of the study was to determine the prevalence, approach and behavior towards medication storage & self-medication practice amongst the youth in Karnataka, India. Methodology: A pre-cross sectional survey was conducted, administering a pre-piloted questionnaire among the target population. Sample size of 150 was analyzed using the percentage method. Results: Out of 150 respondents, 84.62% were found to store medications in their rooms. The prevalence of self-medication was 88.6%. The most common reasons for self-medication were: respondents’ knowledge about the illness & its treatment (47.06%), the time saving factor (44.12%), and prescriber’s ineffective medications (8.82%). Commonly stored medications included analgesics/anti-pyretic (28.07%) and anti-infectives (17.54%). Others included were ENT drugs (14%), Gastrointestinal (GIT) drugs (14%), skin products (6%), Vitamins (8%), ayurvedic medicines (10%), while remaining were categorized as miscellaneous (15.33%). Other considered parameters include: awareness about proper use & expiry dates, and storage & disposal condition. It was concluded that medication storage and self medication were highly prevalent among students. Discussion: There is an immediate need to educate...
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Posted by admin on Aug 1, 2012 in |
Matrix tablets of timolol maleate were prepared using hydrogel forming natural polysaccharides like sodium alginate, xanthan gum and guar gum alone and with hydrophobic polymers like ethyl cellulose and hydroxyethyl cellulose by direct compression method. The Fourier-transform infrared spectroscopy of drug-polymer and polymer-polymer was studied and revealed the compatibility of drug and polymer. All the precompression parameters like angle of repose, bulk density, tapped density, Carr’s index and Hausner’s ratio for drug polymer mixture were found within limits of pharmacopeial specification. The tablets were studied for post compression parameters like hardness, thickness, weight variation and drug content were in acceptable range of pharmacopeial specification. The tablets were studied for invitro swelling index, invitro drug release study. The effect of hydrophobic polymers like ethyl cellulose and hydroxy ethyl cellulose were also studied on invitro swelling and drug release. The scanning electron micrography was done for selected swellable matrix tablets revealed that the tablets containing guar gum and hydroxy ethyl cellulose (F9) showed compact structure with fewer cracks. All the matrix...
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Posted by admin on Aug 1, 2012 in |
The crude ethanolic extract of the root of Lagenaria siceraria (Molina) Standley (Family: Cucurbitaceae), was evaluated for its possible anti-inflammatory activity and determination of total flavonoids and tannin contents growing in Bangladesh. The anti-inflammatory activity was studied using carrageenan and histamine-induced rat paw edema test at different doses (200 and 400 mg/kg body weight) of the ethanol extract. At the dose of 400 mg/kg body weight, the extract showed a significant anti-inflammatory activity both in the carrageenan and histamine-induced oedema test models in rats showing 59.57% and 58.86% reduction in the paw volume comparable (P<0.01) to that produced by the standard drug indomethacin (63.12% and 66.45%) at 4h respectively. The percentage inhibition of the oedema paw volume by the 400 mg/kg body weight of the extract was also statistically significant (P<0.05; P<0.01) compared favorably with the indomethacin treated animals at 1, 2 and 3 h in both models. The total flavonoids and tannins content were calculated as quite high in ethanolic extract (244.29 mg/g of quercetin equivalent and 84.59...
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Posted by admin on Aug 1, 2012 in |
A simple isocratic HPLC method has been developed and validated as per ICH Guidelines for simultaneous and stability indicating determination of Cetirizine Hydrochloride and Ambroxol hydrochloride in pharmaceutical liquid oral dosage form syrup. Separation was achieved in Hypersil BDS C18 column, 5 μ, and 250 mm x 4.60 mm id with flow rate of 1.5 ml/minute and the detection at 230nm. 0.2 molar Ammonium phosphate with the pH of 4.0 with dilute orthophosphoric acid of about 65 percentage in acetonitrile combination was used as a mobile phase. Developed method validated as per ICH Guidelines, prior all the parameter system suitability was carried with five repeated injection of standard solution at the concentration of 50 μg/mL and 30 μg/mL Cetirizine Hydrochloride and Ambroxol Hydrochloride respectively. Percent RSD of five replicate injections of Cetirizine Hydrochloride and Ambroxol Hydrochloride and Tailing factor was found below 2.0% and 2.0 overall analyses respectively. A linear response was observed over the concentration range of 25.06 to 75.18 and 15.13 to 45.38ppm for the assay of...
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Posted by admin on Aug 1, 2012 in |
Objective of the present work is to develop orodispersible tablets of Salbutamol sulphate to improve bioavailability, disintegration time, dissolution efficacy and patient compliance. Orodispersible tablets are the fast growing and highly accepted drug delivery system in now days mainly to improve patient compliance. Orodispersible tablets have number of advantages over conventional dosage forms, because of that Orodispersible tablets have emerged as an alternative to conventional dosage forms. Orodispersible tablets dissolve or disintegrates instantly on the patient tongue or buccal mucosa. Orodispersible tablets of solbutamol sulphate were prepared using superdisintegrants, ac di sol, sod.cmc, alginic acid, chitosan, mcc, as diluents by direct compression method. Twelve formulations were prepared using the superdisintegrants at lower, intermediate & higher concentration. Mannitol is used to enhance the organoleptic properties of tablets. Tablets were evaluated for uniformity of weight, hardness, friability, water absorption ratio, dispersion time, disintegration time and in vitro drug release. All the formulations showed disintegration time less than 33mins and drug release by dissolution (100% at the end of 10...
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