Posted by admin on Aug 1, 2012 in |
The aim of present investigation is to study the effect of oral administration of drug acetylsalicylic acid (ASA, aspirin) on female albino rat, Rattus norvegicus. The female rats (n=24) were allocated into 2 groups as control (n=12) and treated (n=12). The treated rats were given oral dose of aspirin 100 mg/ kg body weight for 15 days (n=6) and 30 days (n=6). Tissues enzymological estimations such as ACP (Acid Phosphatase) and ALP (Alkaline Phosphatase) along with histopathological studies of reproductive organs (ovary and uterus) were done. The present investigation indicated that, aspirin significantly increased ACP and ALP content in reproductive tissues and also caused significant histopathological variations in reproductive organs such as ovary and uterus by modulating certain enzyme metabolism in female albino...
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Posted by admin on Aug 1, 2012 in |
Celosia argentea is a medicinal herb belonging to the family Amaranthaceae has been used traditionally in Ayurveda for the treatment of diarrhoea and dysentery. Extensive studies have been carried out to substantiate its various claimed pharmacologic activities. Present communication records the Pharmacognostic evaluation like Macroscopic and Microscopic characters and Physiochemical evaluation like Foreign matter, Moisture content, pH, Ash value, Extractive value, Crude Fibre content and Foaming Index. Fluorescence analysis and Phyto-chemical investigations on this plant reveal the presence of Carbohydrates, Amino acids, Glycosides, Saponins, Alkaloids, Flavonoids, Phenolic compound and Tannins in different extracts. Pharmacognostic and Qualitative chemical evaluation of whole plant should be helpful for identification and preparation of monograph of the...
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Posted by admin on Aug 1, 2012 in |
Nanoparticles, generally considered as particle with a size of upto 100nm, exhibit completely new or improved properties as compared to the larger particles of the bulk material that they are composed of based on specific characteristics such as size, distribution and morphology. In this study ZnO nanoparticle was synthesized by a simple and easy chemical method from ZnCl2. The synthesized nanoparticle was characterized by SEM and EDAX. Antibacterial activity of ZnO was observed against E. coli, Enterobacter sp., Bacillus subtilis, Bacillus cereus, Klebsiella pneumoniae, Staphylococcus aureus, Salmonella typhi, Vibrio cholerae by disc diffusion method. Preliminary Cytotoxicity of nanoparticle was studied by MTT assay against vero cell line. ZnO nanoparticle had shown antibacterial activity against all the tested bacteria and maximum activity was observed against salmonella typhi. ZnO nanoparticles has shown less cytotoxicity effect on vero cell than...
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Posted by admin on Aug 1, 2012 in |
The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Targeting of drugs to the colon via oral administration protect the drug from degradation or release in the stomach and small intestine. It also ensures abrupt or controlled release of the drug in the proximal colon. Various drug delivery systems have been designed that deliver the drug quantitatively to the colon and then trigger the release of drug. This review will cover different types of polymers which can be used in formulation of colon targeted drug delivery...
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Posted by admin on Aug 1, 2012 in |
The present study describes the antifungal activity of Durenta erecta L. against some phytopathogenic fungi: Aspergillus niger, A. flavus, A. fumigatus and Penicillium sp. For this purpose, methhanolic extract of leaf, stem and root were prepared and tested by “Disc Diffusion Method”. The methanol extract was subjected to preliminary phytochemical analysis. Alkaloids, saponins, and polyphenols (tannins and flavonoids) were detected as phytoconstituents of the methanol extract. As a result of antifungal activity it was found that the extract of leaf generally revealed antifungal activity against all Aspergillus spp. but activity was highest against A. fumigatus (20±0.67 mm). Stem extract showed less activity against all test fungi but no activity against A. flavus. Root extract did not show any antifungal activity except A. fumigatus with less activity...
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