Posted by admin on Sep 1, 2012 in |
Tizanidine is a muscle relaxant agent, with the half life of 2.5 hours and requires daily doses to maintain adequate plasma concentrations. The present study was undertaken to with an aim to formulation development and evaluation of Tizanidine hydrochloride sustained release tablets using hydrophilic polymer to sustain the action of Tizanidine. Different batches of Tizanidine hydrochloride were prepared based on preformulation studies using HPMC K100M HPMC K4M and HPMC K100 having different viscosities to calculate the sustained release properties. Tizanidine hydrochloride was analysed by using HPLC using wavelength 240 nm. Results of in-vitro study indicate that the trial formulation 5 having considerable sustaining property. From the discussion it is concluded that the trial formulation 5 had considerable in-vitro drug release. Trial formulation 5 can be taken as an ideal or optimized formulation of sustained release tablets for 12 hours release and it fulfils all the requirements for...
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Posted by admin on Sep 1, 2012 in |
Objective: To determine the effect of amlodipine on blood glucose levels through oral glucose tolerance test in normoglycemic albino Rats and the magnitude of its effect on basal v/s glucose induced glycemic value compared to control. Methods: Rats were divided into control and test groups to study the effect of glucose induced glycemic changes in normal rats following oral administration of amlodipine. The control group received 1 ml of distilled water everyday, test group received amlodipine everyday in the dose of 1.5 mg/Kg BW for 3 days.On the third day, 2 hours after drug administration both groups were administered oral glucose in the dose of 0.6 gm/Kg BW. The blood glucose levels were measured at 0, 60 and 150 minutes after glucose administration by rat tail snipping method using ACCUCHEK glucometer. Results: The mean CBG of Test group is significantly higher(P<0.001) at all times of the glucose challenge i.e. 0, 60, 150 minutes from the time of glucose administration compared to control group. The optimal hyperglycemia was seen at...
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Posted by admin on Sep 1, 2012 in |
A new specific, selective and inexpensive spectrofluorophotometric method has been developed for determination of Nelfinavir mesylate in bulk drug and its dosage form. Fluorescence spectrum of Nelfinavir mesylate in methanol showed excitation wavelength at 253 nm and emission wavelength at 508 nm. The calibration curve for Nelfinavir mesylate was found to be linear over the concentration range of 100-225 ng/mL with correlation coefficient of 0.988 for bulk drug. Limit of detection and limit of quantification were found to be 8.42 ng/mL and 28.09 ng/mL respectively. Method was validated as per ICH guidelines and found to be suitable for estimation of Nelfinavir from bulk drug and its pharmaceutical dosage...
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Posted by admin on Sep 1, 2012 in |
An in vitro study was conducted for screening antibacterial activities of seeds of Trigonella foenum-graecum (fenugreek)and rhizomes of Zingiber officinale (ginger), in their different forms viz. aqueous extracts, essential oils and powders against some common food borne pathogens. Bacterial strains involved in the study were Bacillus cereus (MTCC 430), Enterococcus feacalis (MTCC 439), Escherichia coli (MTCC 1687), Psuedomonas aeruginosa (MTCC 424) and Staphylococcus aureus (MTCC 5021). Results revealed that powdered forms of T. foenum-graecum and Z. officinale remained ineffective in arresting the growth of all the bacterial strains under investigation. During preliminary screening, aqueous extracts and essential oils of test spices did not exhibit any growth inhibitory zone towards any test bacteria. In broth dilution technique, essential oil of Z. officinale arrested all the bacterial strains under observation while essential oil of T. foenum-graecum and aqueous extracts of T. foenum-graecum and Z. officinale remained...
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Posted by admin on Sep 1, 2012 in |
Newer NSAIDs like Aceclofenac and Lornoxicam are being marketed by pharmaceutical industries with claims of better efficacy and safety than conventional NSAIDs like Diclofenac. So this study aims to comparatively assess the safety, efficacy and cost of Aceclofenac, Lornoxicam and Diclofenac in patients of musculoskeletal disorders. Patients presenting with musculoskeletal disorders were randomized into three treatment groups (50 in each). Comparative analgesic efficacy assessment between the three drugs were done by using visual analog scale (VAS) reading on Day-0 and then weekly till 3 weeks; adverse drug reaction (ADR) information were collected by spontaneous reporting from patients and by active surveillance and were recorded in a predesigned proforma. Relative cost was assessed by comparative unit cost price of individual drugs (of different pharmaceutical companies). It was observed that Lornoxicam, Aceclofenac and Diclofenac are equally effective as analgesic. Both Aceclofenac and Lornoxicam have similar ADR profile which is significantly less than that of Diclofenac. Though analgesic activity and safety profile of Aceclofenac is comparable to Lornoxicam, but Aceclofenac is cheaper...
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