Posted by admin on Jul 1, 2012 in |
The antifungal, antimicrobial, antioxidant and cytotoxic activities of methylene chloride, methanol and hydroethanolic extracts of the leaves of Bridelia ferruginea and sterm bark of Pteleopsis suberosa were investigated against six Gram Positive and Gram negative strains bacteria and six species of Aspergilus. The antimicrobial activity was investigatedby the microtest method using p-iodonitrotetrazolium and theantifungal activity by measuringthe mycelial and sporulation inhibition. The phytochemical study was performed on Thin Layer Chromatography and antioxidant activity was assayed using qualitative and quantitative 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging test. The methanolic extract of Pteleopsis suberosa showed better Minimum Inhibitory Concentration against all the tested bacteria. The strongest activity was observed with the methanolic extract of Pteleopsis suberosa against S. aureus meticillin resistant with Minimum Inhibitory Concentration value of 78µg/ml. All extracts showed an interesting sporulation inhibitory percentage up to 60% whereas little to moderate inhibition was obtained against mycelial development (9.18 to 57.53%). The antioxidant activity of extracts increased in dose dependent manner. The methanolic and hydroethanolic extracts were the most active with inhibitory percentage...
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Posted by admin on Jul 1, 2012 in |
Medicinal plants represent a rich source of antimicrobial agents. The traditional medicine involves the use of different plant extracts of bioactive constituents. Ficus is a huge tropical deciduous or evergreen tree with more than 800 species. Purpose: Ficus benghalensis, Ficus religiosa, Ficus recemosa are important ingredients in many siddha, ayurveda and traditional formulations and used for the treatment of bacterial infections. An attempt was made to study the antibacterial effect of Ficus sp., by appropriate methods. Method: The acetone, methanol, ethylacetate extracts of Ficus benghalensis, Ficus religiosa, Ficus recemosa were evaluated for antibacterial activity against medically important bacteria Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris, Bacillus subtilis, Staphylococcus aureus. Phyto constituents of three plants were screened. The in-vitro antibacterial activity was performed by agar disc diffusion assay. Results: The plant extract that showed higher active antibacterial activity against tested bacterial strain was chosen analyse beta-lactamase inhibitory activity. Ficus sp. Showed more antibacterial activity on Escherichia coli, Staphylococcus aureus and Proteus vulgaris. Conclusion: Amongst the plant species screened, Ficus benghalensis extracts...
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Posted by admin on Jul 1, 2012 in |
Drug interaction represents a major problem in day- to- day practice. The incidence of adverse reactions increases almost exponentially as the number of drugs co prescribed rises, and this is in part due to interaction. Critically ill, chronically ill and elderly patients are particularly at risk of drug interactions due to polypharmacy as well as impaired homeostatic mechanisms. The study was aimed to assess polypharmacy and drug interaction in the prescriptions. The study was carried out by taking 200 prescriptions from different departments of our hospital and assessed the drug interaction through Micromedex and Drugs update. Polypharmacy was assessed using Prescribing indicators in WHO drug use indicators. Polypharmacy was observed in 85% of the prescriptions and drug interaction was observed in 58.5% of the...
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Posted by admin on Jul 1, 2012 in |
Seeds of Simmondsia chinensis were extracted with pet ether, benzene, chloroform, ethyl acetate, methanol and distilled water for evaluating its antimicrobial activity and phytochemical analysis. The purpose of screening is to justify, authenticate the use of Indian Medicinal plants in ethnomedicinal or folklore as traditional treasure to cure various ailments. In present investigations attempts were made to screen the Indian Medicinal Plants as antibiotics. The extracts were tested against seven bacteria and three fungi through disc diffusion assay where standard tetracycline and mycostatin (for bacteria and fungi, respectively) were used. The results showed that all the extracts possess good antimicrobial activity against selected test bacteria and fungi. The preset results therefore offer a scientific basis for traditional use of the various extracts of Simmondsia chinensis. All the extracts possessed antimicrobial potential against all test bacteria and fungi which explains that their use in daily life will generate a resistance or immunity to fight against microorganisms. Phytochemical analysis revealed the presence of terpenoids, flavonoids, tannins and...
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Posted by admin on Jul 1, 2012 in |
Antimicrobial activity of ethanol and aqueous extracts of Parinari curatellifolia (stem) were tested against five dental carries causing bacteria and three fungi strains by agar diffusion method. The crude extracts showed a broad spectrum of antibacterial activity inhibiting the five strains of bacteria and the three fungi. The extracts were most effective against Aspergilusflavus, followed by Streptococcus mutans and Staphylococcus aureus respectively. S. mutans and S. aureus were the only microorganisms that showed zone of inhibition in all the various concentrations of the ethanol extract of P. curatelifolia. Preliminary phytochemical screening revealed the presence of alkaloids, flavonoid, anthraquinones, saponins, tannins, cardiac glycosides, steroids, terpenoids, phlobotanins and...
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