Posted by admin on Sep 1, 2012 in |
Background: Sida rhombifolia L. (Malvaceae) is in flora of Asian medicinal herbs and used traditionally in West of Burkina Faso for the treatment of inflammatory diseases, fever, pain and possesses analgesic properties. The aim of the study was to access the biological activities of extract (acetone/water extract) and alkaloid extracts from Sida rhombifolia L. (Malvaceae) in the carrageenan-induced paw edema and croton oil-induced ear edema on the one hand, evaluate their analgesic capacity in Swiss mice and on the other, with an aim to provide a scientific basis for the traditional use of this plants to the treatment of inflammatory diseases. Method: In acute toxicity test, mice received doses of extract (acetone/water extract) from Sida rhombifolia L., extract by intraperitoneal route and LD50 was determined in Swiss mice. However,in anti-inflammatory activity, the carrageenan-induced paw edema and oil croton-induced ear edema in Swiss mice. As for analgesic effects, acetic acid writhing and hot plate methods were used in mice. Results:About preliminary study in acute toxicity test, we obtained LD50 value...
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Posted by admin on Sep 1, 2012 in |
The acute and subchronic toxicities of Nigerian polyherbal antidiabetic remedy, prepared from Gongrenema latifolium and Allium cepa (1:1) leaves was investigated in Swiss albino mice and rats of both sexes. For acute toxicity study, 1000-5000mg/kg of the combined extract were administered orally to rats and observed for 24 hours for obvious toxic symptoms and mortality. The median lethal dose of the combined extract (LD50) was estimated. In subchronic study, 1000-4000mg/kg of the combined extracts were orally administered daily for 90 days. Weight changes and selected biochemical and hematological parameters were determined periodically. At the end of the experiment, the liver tissues were harvested for histopathological examination. The estimated LD50 of the combined extracts was above 5000mg/kg. There was no sign of weakness, anorexia and no significant reduction in body weight. There were non- significant (p>0.05) effects on hemoglobin concentration and PCV. There were transient significant (p<0.05) increases in ALT and AST. Liver cells photomicrographs at the 91st day showed slight changes in histo-architecture of the hepatocytes at 4000mg/kg. These...
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Posted by admin on Sep 1, 2012 in |
Background: β-blocker is an established therapeutic strategy for stage C systolic heart failure based on the American Heart Association guideline, nonetheless limited studies analyzed the role of β-blocker primarily Bisoprolol adding to ACE inhibitor and furosemide combination on the left ventricular function in systolic heart failure patients. Objectives: This study was designed to analyze the role of Bisoprolol adding to ACE inhibitor and furosemide combination on the ventricular function in patients with systolic heart failure particularly on ejection fraction and quality of life. Subjects & Methods: 40 to 80 years old ambulatory patients (N=30) at Dr. Saiful Anwar General Hospital Malang diagnosed as stage C systolic heart failure receiving optimum dose of inhibitor ACE and furosemide combination for at least 2 months. Before Bisoprolol was added, the ejection fraction and the quality of life was observed to assess the baseline left ventricular function then re-observed after 3 months. Results: After the adding of Bisoprolol, there were significant differences in ejection fraction (measured by echocardiography) and quality of life (measured...
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Posted by admin on Sep 1, 2012 in |
Natural resources in general and plant materials in particular are receiving more attention due to their safety as pharmaceutical excipients. Present work assessed the combination potential of natural hydrophobic resin, rosin, and synthetic polymer ethyl cellulose to mask the abhorrent inherent taste of ambroxol hydrochloride, by microencapsulation technique, and its possibility to formulate as a fast dissolving dosage form. Being of natural origin, rosin and its derivatives are biodegradable and biocompatible. Although It has excellent film forming property the native rosin films are brittle and break easily upon handling. The film forming properties of rosin was modified by substituting a part with ethyl cellulose.The prepared rosin-ethyl cellulose composite microspheres by emulsion solvent evaporation technique possessed good sphericity, smooth surface morphology, uniform and narrow size distribution (10-90 µm), when analyzed by scanning electron microscopy. PEG 400 was used as plasticizer because of its hydrophilicity, biocompatibility and their excellent plasticizing activity. Method of preparation has influenced the particle size and drug loading efficiency. Drug-polymer compatibility was confirmed by Fourier transform infrared...
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Posted by admin on Sep 1, 2012 in |
Eurycoma longifolia (E. longifolia) Jack has been widely used in traditional medicine for its antimalarial, aphrodisiac, anti-diabetic, antimicrobial, anti-pyretic and anticancer activities. As yet, no study has been done on biosafety of partially purified sub-fraction (TAF2) of the crude methanolic extract of E. longifolia roots. This study aims to evaluate, in vivo, the effects of TAF2 on the haematological, biochemical and histology parameters in nude mice. Male nude mice were treated orally with TAF2 (200 mg/Kg/mouse) every other day for 16 days. Untreated mice were used as controls. Blood samples were collected by intra-cardiac puncture and haematological and biochemical parameters were analyzed by using animal blood counter and automated chemistry analyzer, respectively. Hematoxylin-eosin stain (H&E) was used to evaluate the histopathology changes. Blood cells morphology was assessed by Wright stain of the thin blood films. The results showed normal blood haematology and clinical chemistry. Histological examination of TAF2 treated vital organs (kidney, liver and spleen) of mice showed no apparent change with the dose used. In conclusion, E. longifolia...
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