Posted by admin on Aug 1, 2012 in |
Asthma is a major public health burden that affects a large number of individuals. The prevalence of this chronic disease is very high in Bangladesh. This study is intended to understand the causes of disease and factors that contribute to its progression and to develop improved treatment strategies. The study population included severe acute attack of asthma patients admitted to National Institute of Diseases of the Chest and Hospital, Mohakhali, Dhaka, Bangladesh during October-December 2010. A questionnaire was prepared containing information of age, sex, family history, socio-economic status, food habits, allergic disorders, previous illness, smoking habit, diagnosed asthma, treatments and asthma medications used. Data were collected from a total of 100 patients of three wards in the hospital by face to face interview of patients, physicians and hospital recorded sheet over a period of three months. Out of 100 patients, 85% were male and 15% were female. The study showed 6% were below 30 years of age, 69% were ageing 30-60 years and 25% were above 60 years of...
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Posted by admin on Aug 1, 2012 in |
World Health Organization (WHO, Geneva) has appreciated the importance of medicinal plants for public health care for use in developing nations. Putranjiva roxburghii Wall. is having important role in the traditional Ayurvedic and Unani systems of holistic health and herbal medicine of the East. The leaves of Putranjiva roxburghii Wall. are reported to have good medicinal values in traditional system of medicine. The present study highlights the pharmacognostical studies including parameters such as powder analysis by microscopical evaluation, color reaction, and study of physicochemical parametersof the Putranjiva roxburghii Wall. leaves. These observations will help in the pharmacognostical identification and standardization of the drug in the crude form and can be used to distinguish the drug from its...
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Posted by admin on Jul 1, 2012 in |
Background: Prescription of drugs, which needs to be continuously assessed and refined according to disease progression. It not only reflects the physician’s knowledge about drugs but also his/her skill in diagnose and attitude towards selecting the most appropriate cost-effective treatment. Antimicrobials are among the most commonly prescribed drugs in hospital. As per literature, they account for over 50% of total value of drugs sold in our country. Such studies have been sparse from Gujarat and hence, this study was undertaken. Methods: Retrospective study was carried out by collecting 350 prescriptions containing antimicrobial agents in paediatric department at Sir Sayajirao General (SSG) Hospital, Vadodara to assess the prescribing patterns of antimicrobial agents. All information about the drugs details recorded in pre-tested Proforma that was finalized by our Pharmacology department. Results: Total 350 prescriptions containing 690 antimicrobial drugs were prescribed in patients during study. Of them aminoglycosides (233; 33.77%) was frequently prescribed followed by β-lactam group (191; 27.68) and cephalosporins (176; 25.5%). Average numbers of antimicrobials per prescription was 1.97.Out of...
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Posted by admin on Jul 1, 2012 in |
The study was designed to investigate the impact of colonic pH changes on formulated colon targeted Mesalamine matrix tablets in the treatment of inflammatory bowel disease (IBD). Mesalamine tablets were fabricated with guar gum as Polymer system. The different batches of Mesalamine tablets (GMM1-GMM6) were compressed with increasing proportion of guar gum and HPMC E15 LV. The different buffer conditions were chosen to mimic the pH changes in terminal part of the ileum as well as the colon. A separate two in vitro studies were conducted in all the formulations. The impact of the pH changes on the coated tablets in normal pH condition and reduced pH condition (pH reduced during IBD) were compared. In IBD the pH of the colon falls below its normal level. The extent of pH change depends on the severity of the disease. The study was designed to evaluate the in vitro dissolution characteristics of Mesalamine matrix tablets in a variety of simulated fluids (pH range 1.2, 6, 6.8, 7.2, 5). The results indicated...
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Posted by admin on Jul 1, 2012 in |
Celecoxib, a diaryl substituted pyrazole, is practically insoluble in water which precludes its use in parenteral and liquid dosage forms. This study explores the solubility enhancement of celecoxib using hydrotropy and cosolvency solubilization approaches. The equilibrium solubility studies were performed using hydrotropes piperazine, sodium citrate, and urea and cosolvents PEG 200, PEG 400, PEG 600, DMA, Ethanol and Propylene glycol at various temperatures. Parenteral formulations using hydrotrope and cosolvents were developed and studied for accelerated stability study. The solubility of celecoxib was found to increase upto 45 times in 3M piperazine solution and upto 10232 times in PEG 600 at 25±20C. The results of solubilization study showed that the increase in solubility of celecoxib is smaller in piperazine and urea when used alone as compared to the increase in solubility which was found when these hydrotropes were used in combination with cosolvents PEG 600, PEG 400, DMA and Eth. Stability studies indicated that all the formulations stored were found to be stable for drug content, pH and change in...
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