Posted by admin on Mar 1, 2012 in |
Objective of the present study was to prepare and evaluate floating Microspheres using different ratio of ethylcellulose to control the release rate of 5-Fluorouracil (5-Fu) which was taken as a model drug. The microspheres were prepared by the modified emulsion solvent diffusion technique using different ratio of ethanol (ETN) and acetone (ACTN) as solvent system. To study the morphology of microspheres optical and scanning electron microscopy was used. The maximum yield of microspheres was up to 84.85±3.97%. Microspheres showed passable flow properties. On the basis of results of optical microscopy particle size range was found to be ranging from 130.90±12.10 to 175.43±12.32 mm. SEM photographs confirmed their spherical size, perforated smooth surface and a hollow cavity in them. Microspheres exhibited floating properties for more than 10 hours. In vitro drug release studies were performed in 0.1N HCl with 0.1 % SLS. Different drug release kinetics models were applied for selected...
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Posted by admin on Mar 1, 2012 in |
The objective of the study was to formulate controlled release matrix tablets of losartan Potassium by using a combination of hydrophilic synthetic polymer like poly (ethylene oxides) and natural gums like xanthan gum, karaya gum and guar gum. A combination of synthetic hydrophobic polymers like methacrylates with synthetic hydrophilic polymer like poly (ethylene oxide) was also used in the preparation of matrix tablets and evaluated for their influence on controlled drug release. The matrix tablets were prepared by direct compression process and evaluated for hardness, weight variation, friability, swelling index and for in-vitro release of the drug. Preliminary evaluations showed that matrix tablets containing xanthan gum, guar gum and sodium alginate alone or in combination could not efficiently retard the drug release for prolonged period of time. The tablets containing combination of natural polymers and poly(ethylene oxides) and also methacrylates and poly(ethylene oxides) exhibited controlled release for a prolonged period of time. All the physical characteristics evaluated for the tablets were found to be within the acceptable...
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Posted by admin on Mar 1, 2012 in |
The synthesis of benzimidazoles derivative involves subsequent synthesis of 4-(2-chloro-ethoxy)-benzaldehyde, 4 methyl benzaldehyde followed by benzimidazoles derivative by reaction between amines derivatives and o-phenylenediamine in dimethyl farmamide (DMF) as solvent in the presence of iodine as a catalyst. Iodine is a commercial and environmentally benign catalyst. The yield of all benzimidazole derivatives was found to be in the range of 75 – 94%. The purity of the compounds was ascertained by melting point and TLC. The synthesized compounds were characterized by using IR,1H NMR, and MASS spectral data together with elemental analysis. The synthesized benzimidazole compounds were screened for analgesic and anticonvulsant activity in albino rat (100-200gm) by using Writhing test and maximal electroshock (MES). Out of all compound studied only PS-3, PS-4, PS-5 and PS-6 showed significant analgesic activities and response against MES...
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Posted by admin on Mar 1, 2012 in |
Objective: The aim of the study was to have bio-analytical approach for detoxification process of two poisonous plant materials viz. Aconitum laciniatum (root) and Abrus precatorius (seed) which are used in Ayurvedic preparations. Materials and Methods: For both the species proximate analysis was carried out. For the same plants HPTLC fingerprinting was compared , before and after detoxification process, using triphala quath. Infra red spectral studies for Abrus precatorius species (red and white) were compared, with respect to detoxification process. Protein fingerprinting was carried out for various Aconitum species available in the market. In support of the results obtained from the above methods for detoxification, safety evaluation , post single dose administration, C1- post single dose administration]was done using albino mice as the study model for Aconitum laciniatum (root) and Abrus precatorius (seeds- red and white). Outcome Measures: Comparison of the results for the crude poisonous herbal material with the material obtained after detoxification in triphala quath. Results: HPTLC fingerprinting, Infra red spectral studies, safety evaluation study (animal toxicity)...
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Posted by admin on Mar 1, 2012 in |
Rutin belongs to a class of plant secondary metabolites called flavonoids. Rutin is believed to be a vital nourishing supplement as it is able to make the capillaries stronger. But when administered orally it shows poor absorption because of less lipophilicity. To overcome this limitation, the present study was aimed to develop Rutin- phospholipid complex in different ratio to improve the lipophilic properties of rutin. The prepared complex was evaluated for physicochemical properties and in-vitro DPPH radical’s scavenging activity. The physicochemical properties of the complex were analyzed by ultraviolet-visible spectroscopy (UV), infrared spectroscopy (IR) and X-ray diffractometry (XRD). The results showed that rutin-phospholipid in the complex were joined and did not form a new compound. Results of DPPH radical are scavenging activity revealed that among all ratios of complex, 1:3 next to this 1:2 followed by 1:1. The study was concluded that the free radical scavenging activity was observed in concentration dependent...
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