Posted by admin on Jun 30, 2023 in |
A wound is an injury of living tissue or a break in the epithelial integrity of the upper layer of skin. This may lead to disturbance of skin anatomical structure and functions. Nowadays, wound healing is a challenging clinical problem. So, effective wound management is required. Different in-vitro, in-vivo and ex-vivo models have been developed to evaluate wound healing activity. The present study aims to evaluate the in-vitro wound healing potential of methanol extract of starfish Protoreaster linckii on the Human L-32 Cell line through scratch assay. The wound-healing properties of the Protoreaster linckii extract at different concentrations (25µg/ml, 50µg/ml and 100µg/ml) were assessed. The wound closure and migration of cells were directly related to the concentrations of the extract. The extract concentration increased from 25µg/ml to 100µg/ml and the percentage of wound healing (40% – 98%) also increased. The results showed that the methanol extract of P. linckii has potential wound-healing activity and it can serve as an alternative therapy against synthetic drugs for wound...
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Posted by admin on Jun 30, 2023 in |
The main aim of the current research is to formulate and evaluate the anti-aging cream containing lactic acid and cocoa butter. Skin health and beauty is regarded as one of the most important variables influencing general “well-being” and “health” perception in humans because of that, various anti-aging techniques have been created in recent years. Uneven pigmentation, increased wrinkles, loss of elasticity, dryness, and roughness are all signs of skin ageing. Lactic acid dissolves the connections that hold old, dull cells together on the skin’s surface, allowing them to be removed. Exfoliation is the term for this procedure. Lactic acid helps your skin shed old cells and replace them with new ones by speeding up cell turnover and stimulating cell renewal. As a result of exfoliation, lactic acid prevents and delay new fine lines and wrinkles from developing. Cocoa butter used in the formulation, gives the skin moisture and helps to remove the dark spots because of its anti-oxidant...
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Posted by admin on Jun 30, 2023 in |
Heavy metal pollutants in tannery effluent can be removed using the bioremediation technique. This study intends to extract bacteria that may reduce heavy metals and molecularly characterize them using 16S rRNA PCR in samples taken from tannery effluent. It also studies their cell-free immobilized enzymatic activity. Thirteen bacterial isolates were identified based on morphological, cultural, and biochemical characteristics. The top four isolates, A, B, sp5, and sp3, were identified as Brevundimonas sp, Proteus mirabilis, and Alcaligenes faecalis by morphological, cultural, biochemical, MALDI-TOF Analysis, and molecular characteristics using 16S rRNA. These organisms showed good tolerance to zinc, nickel, and chromium. When heavy metals like zinc and chromium have reduction properties, by ICP-OES to assess the concentration of heavy metals. Further investigation, beads were immobilized, and its activity was...
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Posted by admin on Jun 30, 2023 in |
Background: Children with mild intellectual disabilities demonstrate wide diversity in academic and behavioural performance. They develop adequate social, personal, and communication skills. As adults, they function in a variety of contexts. Persons with moderate intellectual disabilities have limited intellectual abilities, have problems in abstracting and generalizing, and are not ready for much academic work until their early teens. They show rather clear-cut deficits in adaptive behaviour. The children with mild intellectual disabled show underachievement in all academic areas, have difficulty in working with abstract ideas, and have problems generalizingtheir learning to new situations. The study aims to explore the effect of social skills on the problem behaviour and academic performance of children with mild intellectual disability in aninclusive setting. Materials and Methods: 400 Children with intellectual disability and their teachers in the inclusive set-up both in rural and urban areas of Trichy District were chosen for the study. The data was collected through the Social Skills Rating System (SSRS)-Gresham & Elliott, 1990). Obtained data were transcribed and analyzed using Descriptive and Differential...
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Posted by admin on May 31, 2023 in |
This study aimed at identifying promising breast cancer inhibitors through in-vitro and in-silico studies. Ocimum basilicum. L is a traditional herb used for varied ailments. The present study is designed to evaluate the anti-carcinogenic potency of Palustric acid and Andrographolide against the MCF-7 cell line by in-vitro analysis. Further in-silico examination was performed to detect and formulate Receptor-ligand complex of estrogen using molecular docking technique. In-vitro study was conducted using MTT assay and microscopic examinations to determine the cell viability and morphological changes in MCF-7 cells. In-silico, scrutiny was performed using virtual screening, Docking, ADME, and molecular dynamic simulation to evaluate the stability of the compounds. Palustric acid and Andrographolide against the MCF-7 cell line by in-vitro analysis. Further in-silico examination was performed and showed an outstanding anti-cancer potential, with dose- and time-dependent patterns in MTT assay and through the fluctuating organization of MCF-7 cells. In-silico analysis showed that the selected lead compound-complex exhibited good stability and was a highly potent inhibitor against the target breast cancer receptor. This...
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