Posted by admin on Apr 30, 2023 in |
Allopathic drugs are generally prescribed for Diabetes Mellitus (Type-II) patients. As the disease is chronic in nature, it necessitates the use of alternative medicine(s) either to supplement the existing allopathic therapy and/or to reduce the associated side effects with their chronic use. The use of herbal drugs is presumed to be safe option due to fewer side effects. However, evaluation of safety of their combination by scientific validation is very essential. Here we evaluated the safety of routinely used second generation drug Gliclazide along with Berberine (herbal drug). The study was conducted in two dissimilar species, rats, and rabbits. In rats and rabbits, the dose of 100 mg/kg of Berberine and 1 mg/Kg Gliclazide dosed separately produced~30% reduction in blood glucose. When both Berberine and Gliclazide were given in combination at similar doses, reduction in blood glucose was found to be ~60%, suggesting significant pharmacodynamic interaction between them. Also, in the rabbit study, Gliclazide pharmacokinetic parameters were studied. We observed significant changes in the pharmacokinetic parameters of Gliclazide (AUC,...
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Posted by admin on Apr 30, 2023 in |
Physical interactions between proteins are cardinal to biological processes. To restore their function, proteins must interact with one another. Hub proteins are densely interconnected proteins with a wide range of biological significance and are also to blame for several illnesses, including cancer, autoimmune disorders, and neurodegenerative diseases. The most prevalent of these is Parkinson’s disease. SNCA, alpha synucelin is a hub protein that is the main cause of this disease; along with this DJ 1 and Parkin also responsible for Parkinson’s disease. Through this study, we performed a molecular-level comparative analysis on hub-proteins of Parkinson’s disease with selected synthetic drugs using the in-silico approach. The binding energy and complex energy identified the better efficacy of the drug. The Lipinski rule of filtering and the ADMET pharmacological parameters were satisfied by seven out of the twelve medicines. Levodopa, among these medications, had superior effectiveness with 4RKW and 5C32 in both approaches. Better Lib Dock scores, binding energies, and complex energies with 4RKW were displayed by safinamide. The molecular dynamic modelling...
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Posted by admin on Apr 30, 2023 in |
With the popularity of biologics, treatment for several inflammatory diseases has improved significantly. Biologics are a group of drugs obtained from biological sources that primarily function by suppressing part of the host immune system. However, this process comes at a cost, as it has been reported that the use of biologics carry a major risk in the form of tuberculosis. To verify this claim, a meta-analysis of biologic therapy vs. placebo therapy was designed to test biologics of different inflammatory diseases and check for tuberculosis as their side effect. This test included psoriasis, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, and ulcerative colitis. It was found that biologics used in treating these diseases were mainly responsible for the spread of tuberculosis as a side effect. By mining different databases for literature mentioning biologics that qualify clinical trials and checking for heterogeneity for each study, primary measures were tested for each disease to determine the spread of tuberculosis when treated with these compounds. Meta-analyses were conducted for the study...
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Posted by admin on Apr 30, 2023 in |
The current study’s purpose was to develop and test a multi-herbal anti-diabetic quick-dissolving tablet compared to a commercially available metformin tablet. The multi-herbal anti-diabetic tablet contains natural medicines with anti-diabetic properties, such as Curcuma longa, Cinnamomum zeylanicum, Zingiber officinale, and Trigonella foenumgraecum. This mixture contains the botanical extracts Curcuma longa, Cinnamomum zeylanicum, Zingiber officinale, and Trigonella foenumgraecum. MCC is employed as a diluent and sodium saccharin as a sweetening agent in the tablet formulation to attain this purpose. In the formulation of tablets, superdisintegrants such as crospovidone, sodium starch glycolate (SSG), and a blend of crospovidone and sodium starch glycolate were used to improve dissolve rate and disintegration. Weight variation, drug content uniformity, hardness, friability, wetting time, in-vitro dispersion time and in-vitro drug release investigations were performed on the tablets. Every parameter’s evaluation results for the poly-herbal anti-diabetic pill were within acceptable boundaries. The thickness, hardness, weight fluctuation, friability and in-vitro drug release investigations of the poly-herbal anti-diabetic tablet were all found to be within acceptable...
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Posted by admin on Apr 30, 2023 in |
Drotaverine (DRO) is an anti-spasmodic medication inhibiting phosphodiesterase-4, an enzyme that breaks down cyclic adenosine monophosphate (cAMP). PDE4 inhibition causes an increase in cAMP, which causes smooth muscle relaxation. For DRO, especially the HPTLC technique and stability indicating studies through HPTLC method have not been reported properly in any database. The current research focuses only on a significantly improved HPTLC-based exact, accurate, and specific approach for DRO identification in the presence of degradation constituents employing densitometric detection.DRO was spotted in 6 mm bandwidths with a Camag 100L sample syringe (Hamilton, Switzerland) on a silica gel G60 F254 pre-coated HPTLC aluminium plate with a thickness of 250 µm using a Camag® Linomat-IV applicator. The application rate was 0.4 L/s, with a 6 mm separation between the two bands. Linear ascending development was carried out in a 20 cm × 10 cm twin trough glass chamber, which was then saturated with the mobile phase (Toluene: Methanol; 7:3 v/v).The method was found to be linear over the 200-1200 ng/band range. The stability-indicating...
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