Posted by admin on May 1, 2012 in |
The conventional chemotherapeutic agents in oncology drug discovery still exhibit poor specificity in reaching tumor site and often restricted by dose-limiting toxicity. The combination of developing drug formulation by utilizing both controlled release technology and drug targeting technology may provide a more efficient and less harmful solution to conquer the limitations found in conventional chemotherapy. In this study, the anticancer drug curcumin was encapsulated in a polymeric magnetic nanoparticle which was synthesized with polymers β-cyclodextrin cross linked with epichlorhydrin, hydrophobically modified dextran byoleoylchloride and magnetite as magnetic material. Particle size, surface morphology, zeta potential and magnetic measurements were used to characterize the developed drug formulations. The developed drug-iron conjugated nanoparticles were found to be within the size range of 100nm with excellent negative surface charge (>-30eV) and spherical in shape. The magnetic susceptibility and magnetization curve substantiate the super paramagnetic property of the developed drug formulation. Furthermore, the drug content and encapsulation efficiency found was directly proportional to epichlorhydrin β-cyclodextrin concentration in the developed formulation. The in-vitro release profile...
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Posted by admin on May 1, 2012 in |
In the present study, we investigated neurobehavioral activity of ethanol extract of the aerial parts of Derris trifoliata (Lour.) in mice as a part of a psychopharmacological screening of this plant. The effects of the plant extract on CNS were studied by using potentiation of phenobarbitone-induced sleeping time and exploratory behavior in mice. The crude extract (500 mg/kg body weight) significantly (P<0.001) potentiated onset of sleep and prolonged the total sleeping time in mice. In tests for exploratory behavior, the plant extract (1000 mg/kg body weight) showed significant effect on ambulation and emotional defecation and also in the open field score in case of staying in single area. The overall results suggest that the ethanol extract of D. trifoliata contains some active principles which may be CNS depressant in...
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Posted by admin on May 1, 2012 in |
Cancer is a public health problem all over the world. Large number of plants and their isolated constituents has been shown to potential anticancer activity. Ethanolic whole plant extract of Madhuca indica showed in vitro cytotoxicity against different human cancer cell lines such as lung, neuroblastima, and colon. There was no growth of inhibition recorded against liver cancer cell line. Sulforhodamine B dye (SRB) assay was done for in vitro cytotoxicity test assay. The in vitro cytotoxicity was performed against five human cancer cell lines namely of lung (A-549), liver (Hep-2) colon (502713 HT-29) and neuroblastima (IMR-32). The activity was done using 100µg/ml of the extract. Against lung (A-549) cell line plant extract showed 83% growth of inhibition. In case of liver (Hep-2)showed no activity reported, where as in case of colon 502713 cell line plant extract showed maximum activity. In case of HT-29 liver human cancer line and IMR-32 neuroblastima cell line plant extract showed 99% and 98% activity...
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Posted by admin on May 1, 2012 in |
Candesartan cilexetil, a prodrug is a racemic mixture containing one chiral center at the cyclohexyloxy-carbonyloxy- ethyl ester group. It is soluble in dimethyl formamide, acetone, methanol, 0.1 N sodium hydroxide solution and insoluble in water. Objective of the present study is to develop a simple, sensitive, accurate, precise and rapid derivative spectrophotometric method for the estimation of candesartan in pure form. For the estimation of candesartan, solvent system employed was absolute methanol and wavelength of detection (λdet) was 268.8 nm for first order derivative spectroscopy. The linearity was obtained in the range 10 – 20µg/ml. The limit of detection is 0.5µg/ml and limit of quantification was fund to be 1.63µg/ml. For the estimation of candesartan, solvent system employed was absolute methanol and wavelength of detection (λdet) was 284.3 nm for second order derivative spectroscopy. The linearity was obtained in the range 40 – 160 µg/ml. The limit of detection is 6.7 µg/ml and limit of quantification was fund to be 20.4 µg/ml. Obtained results showed that there is minimum...
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Posted by admin on May 1, 2012 in |
It is important to treat the mother whenever needed while protecting the unborn from any side effects to the greatest possible extent. Objective of this study is to assess the utilization pattern and the teratogenesity risk of the drugs prescribed among pregnant women in Ayder referral hospital, Mekelle, Ethiopia. Retrospective study was employed to assess drug utilization pattern and teratogenesity risk among pregnant women who were admitted to and/or visited Ayder referral hospital from 11 September 2010 to 9 March 2011. From Patient medical record, FDA pregnancy drug category of prescribed drugs was identified. The total number of pregnant women who were admitted to and/or visited Ayder referral hospital during the study period were 570. Only 217 (41.02%) of them have medication history. The rates of first trimester, second trimester and third trimester pregnancy term were 18 (8.30%), 20 (9.20%) and 179 (82.5%), respectively. According to FDA drug category, our finding reveals that there were few drugs prescribed inappropriately. In conclusion, medication practice during pregnancy in the hospital is...
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