Posted by admin on Dec 1, 2011 in |
A new Sulfamethoxazole Schiff base (E)-4-(4-methoxybenzylideneamino)-N-(5-methylis-oxazol-3-yl) benzenesulfonamide (C18H17N3O4S), and its copper complex were synthesized and the structures elucidated on the basis of Physiochemical methods. The studies indicate an octahedral structure for the complexes with the (C22H27N3O10SCu) formula. The IR spectra suggest that the ligand act as tridentate (from oxygen and two nitrogen atoms) donor. Also the biological activity of the Schiff base and its Cu complex were...
Read More
Posted by admin on Dec 1, 2011 in |
The present study was aimed to develop an extended release tablet of Metoprolol Succinate for the treatment of hypertension. Four extended release formulations F1-F4 were developed using varying proportions of Hydroxyl propyl methyl cellulose K100M, Sodium carboxy methyl cellulose and Eudragit L30 D55 by wet granulation. Five extended release formulations F5-F9 containing HPMC K100M and HPMC 5cps in varying concentration were developed by direct compression. The physico-chemical and in-vitro release characteristics of all the formulations were investigated and compared. Two formulations, F7 and F8 have shown not more 25% drug release in 1st h, 20-40% drug release at 4th h, 40-60% drug release at 8th h and not less than 80% at 20th h and the release pattern conform with USP specification for 24 h extended release formulation. It can be conclusively stated that optimum concentration of HPMC K100M (58-65%) by direct compression method can yield an extended release of Metoprolol succinate for 24...
Read More
Posted by admin on Dec 1, 2011 in |
This study is aimed to assess the bioequivalence of five generic ciprofloxacin tablets from different manufacturer using in vitro dissolution study under biowaiver conditions by RP-HPLC. Dissolution media were USP buffer solutions at pH 1.2 (hydrochloric acid solution), pH 4.5 (acetate buffer solution), and pH 6.8 (phosphate buffer solution). Other general quality assessment tests of these tablets like weight variation, hardness, friability, disintegration time and assay were also determined according to established methods. All brands complied with the official specification for uniformity of weight, friability and disintegration time. Assay of selected tablets revealed that all samples contained over 99% (w/w) of labeled chemical content. The dissolution profiles showed no significant inter brand and intra brand variability. Dissolution results of all the tablet formulations and the innovator brand were further analyzed with difference factor (f1), similarity factor (f2), dissolution efficiency and dunnet,s test. These results indicated that all generic ciprofloxacin tablets included in this investigation were bioequivalent with the chosen innovator brand and so may be used...
Read More
Posted by admin on Dec 1, 2011 in |
Neonatal sepsis is one of the commonest cause of neonatal mortality in the developing world which can be classified into early onset sepsis (EOS) which occurs in the first 7 days of life and late onset sepsis (LOS) which occurs ≥7 days of life. E. coli has been reported to be one of the significant and most common nosocomial pathogen which may cause septicemia, pneumonia and meningitis in the newborn. Most of the antibiotics which have been used extensively as life saving are rendered useless because of the emergence of resistant strains of bacterias. Therefore for determining the prevalence and antimicrobial susceptibility pattern of E. coli which is responsible for EOS and LOS and to establish the relationship with birth weight, a total of 229 blood samples were obtained from the neonates admitted to neonatal intensive care unit (NICU) who showed the clinical signs and symptoms of neonatal sepsis and sent for culture and sensitivity. Out of these 229, 102 showed the positive culture, among which early onset sepsis...
Read More
Posted by admin on Dec 1, 2011 in |
An in-vitro thrombolytic model was used to check the clot lysis effect of four herbal extracts viz., Honey, Nigella sativa, Capsicum frutescens, Brassica oleracea, combination of Honey & Nigella sativa and Honey & Capsicum frutescens along with Streptokinase as a positive control and water as a negative control. And also brine shrimp lethality bio-assay was done using brine shrimp Nauplii and 5% of DMSO as a solvent for the ethanol extracts of Nigella sativa & Capsicum frutescens and Honey. Using an in vitro thrombolytic model, Honey, Nigella sativa, Capsicum frutescens, Brassica oleracea, combination of Honey & Nigella sativa and Honey & Capsicum frutescens showed 26.82%, 47.13%, 57.40%, 62.44%, 56.58% and 44.54% clot lysis effect respectively. From our study, we found that Brassica oleracea, Capsicum frutescens, and combination of Honey & Nigella sativa showed significant % of clot lysis effect with reference to Streptokinase. Again from in vitro brine shrimp lethality bio-assay, we found that the LC50 of Honey, Capsicum frutescens & Nigella sativa were 129.62 µg/ml, 83.33 µg/ml &...
Read More
