Posted by admin on Mar 1, 2012 in |
Epilepsy is a neurological disorder characterized by unprovoked, recurring seizures that disrupt the nervous system and can cause mental and physical dysfunction. Based on the ethnopharmacological information of the plant, the methanol and aqueous extract of the whole plant of MELISSA OFFICINALIS was evaluated for its antiepileptic activity in Swiss Albino Mice .Antiepileptic activity was assessed by using MES and PTZ induced models (250 and 500 mg/kg). Body weight doses were used for the present study. In the MES model the methanol and aqueous extracts showed a dose dependent reduction in the duration of hind limb extensor phase. In pentylenetetrazole induced model methanol and aqueous extracts at dose level of 500mg/kg body weight showed significant reduction in the tonic convulsions induced by PTZ when compared with control group. The results suggest a possible anticonvulsant effect of the methanol and aqueous extracts of Melissa officinalis inSwiss Albino...
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Posted by admin on Mar 1, 2012 in |
The phytochemical analysis of the medicinal plant Kalonchoe pinnata was carried out to evaluate the antioxidant potential. Alcoholic extracts of the leaves was subjected to in vitro antioxidant activity screening models such as inhibition of lipid peroxidation, nitric oxide ,superoxide radical and hydroxyl radical scavenging activity. Ascorbic acid was used as the standard for superoxide anion radical scavenging activities. Butylated Hydroxy Toluene (BHT) is used as standard for anti-lipid peroxidation activity and for nitric oxide scavenging activity Gallic acid is used as a standard. In all the models studied, the extracts showed potent antioxidant activity, thereby augmenting it into the present day system of...
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Posted by admin on Mar 1, 2012 in |
The present study was designed to screen and evaluate the hepatoprotective and antioxidant activity of ethanol extracts of leaf and bark of Naringi crenulata (Roxb) Nicolson (NCL, NCB) against CCl4 induced hepatotoxicity in rats. Liver functions were assessed by the activities of liver marker enzymes, SGOT, SGPT, ALP, total protein, albumin, globulin, total, conjugated and unconjugated bilirubins. It also exhibited antioxidant activity by showing the increased activity of SOD, CAT, GPx and GRD and decreased in TBARS compared to CCl4 treated groups. Silymarin, a known hepatoprotective drug is used for comparison. The plant extracts were effective in protecting liver against injury induced by CCl4 in...
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Posted by admin on Mar 1, 2012 in |
Centella asiatica is a medicinal plant. It is severely affected by leaf spot disease caused by a harmful, antibiotic resistant phyto pathogen Xanthomonas campestris pv. centellae (X. c. pv. c). Farmers used synthetic pesticides to control the disease. When pesticides are applied to control this pathogen, pesticides may cause environmental hazards and health problems in man. But traditionally plants are used to prevent or control the plant diseases in agriculture. It is an eco- friendly, biocontrol, traditional method. Hence the aim of the present study is to control the pathogen in biocontrol method by screening the phytochemicals and antibacterial activity of petroleum ether, chloroform, benzene, methanol and aqueous extracts of fronds of five ferns (Pteridophytes) Adiantum caudatum, Angiopteris evecta, Pteris confusa, Pteris argyraea and Lygodium microphyllum against X. c. pv. c. The methanol extracts of all the ferns gave successful result against the tested bacteria. Phytochemical analysis of all the extracts revealed that antibacterial activity is due to the presence of alkaloids, flavonoids and phenolic compounds. According to the...
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Posted by admin on Mar 1, 2012 in |
In the present study,FDDS of Famotidine, a copmpetative inhibitor of histamine H2 receptors were prepared by using natural gums viz. xanthan gum and guar gum at different drug to gum ratio using sodium bicarbonate and citric acid as gas generating agents and lactose as diluent.FDDS tablets were prepared by wet granulation technique using PVP K30 as granulating agent. The prepared FDDS tablets were evaluated for its pre compression characteristics like bulk density, angle of repose, true density and compresibility index and post compression parameters such as hardness, friability, uniformity of drug content, in vitro floating studies, in vitro dissolution studies. The physical evaluation of all the formulations showed values within the prescribed limits for tests like hardness, friability and weight variation which indicate that the prepared tablets are of standard quality. The floating lag time of all the formulations was less than 10 minutes,All the formulations showed good matrix integrity and retarded the release of drug for 10 hours. Formulation X3 containg drug: xantahne gum ratio of 1:3 showed...
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