Posted by admin on Nov 1, 2011 in |
The primary objective of this study is to evaluate the effect of drug loading and the effect of excipients on the release pattern of Dexamethasone Sodium Phosphate from in situ PLGA implants formed in vitro in gelatin gel. This system is prepared by dissolving a biodegradable polymer (DL-PLGA 70K) in dimethyl sulfoxide (DMSO). Then the drug with excipients or without excipients was added to it. When the drug solution poured into the hallow of gelatin gel, the solvent dissipates into the surrounding gelatin base through diffusion leading phase separation & subsequent coagulation of the polymer and the drug to form a rod like implant in situ. Two types of implants were prepared such as implants containing Dexamethasone Sodium Phosphate and implants containing Dexamethasone Sodium Phosphate with biocompatible excipients such as Tween 20, Tween 60, Span 20, Span 80, Chremophore EL, Chremophore RH40, Stearyl alcohol, Cetyl alcohol, PEG 6000, Stearic acid, GMS, Benzyl Benzoate, Magnesium stearate, Dextrose, Lactose and Arachis oil were used. In vitro dissolution studies were performed in...
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Posted by admin on Nov 1, 2011 in |
Dendrimers are synthetic, highly branched, nanosized, monodisperse macromolecule which proving their applicability in different areas like diagnosis, drug delivery, gene delivery, molecular encapsulation etc. Due to their widespread applications, scientific community is continually engaged in developing newer dendrimers with advanced properties. In the present study, amino dendrimers are synthesized according to procedure given in literature and were utilized for its biocompatibility by observing the influence on RBCs. Along with this amino dendrimers were also utilized for their potential in drug delivery by performing solubilization and drug release studies of Methotrexate (MTX). Up to generation third (G3) dendrimers was prepared by divergent method taking PEG as a core which provides homogenesity during synthesis and increases the biocompatibility to biosystem. A preliminary investigation shows that amino dendrimers caused concentration and time dependent haemolysis which is less than that of amino surface dendrimers like PAMAM having no PEG molecules within it. The solubility of MTX increases to 4.68, 5.93, 8.21 and 11.42 folds for the 0.5, 1, 2, 3 mmol concentrations of...
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Posted by admin on Nov 1, 2011 in |
In the present study, an aqueous extract from a marketed mineralo-herbal preparation Reosto was evaluated for its hypocholesterolaemic and hypertriglyceridemic activities using Triton WR-1339 induced hyper- lipidemic rats as experimental model. Hyperlipidemia was developed by intraperitoneal injection of Triton (200 mg/kg body weight). The animals were divided into control (CG), hyperlipidemic (HG), hyperlipidemic plus Reosto extract (200 mg/kg body weight) (HG + ReA), hyperlipidemic plus Reosto extract (400 mg/kg body weight) (HG + ReB) and hyperlipidemic plus Fenofibrate (HG + FF) treated groups. Intragastric administration of Reosto extract to the rats caused a significant decrease on their plasma lipid levels (quantified using enzymatic kits). In Fenofibrate treated rats, lipid parameters were significantly changed indicating that this aqueous extract may contain products that lower plasma lipid concentrations and may be beneficial in treatment of...
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Posted by admin on Nov 1, 2011 in |
Many herbal remedies have been employed in various medicine systems for the treatment and management of the different diseases. The Tamarinds indica commonly known as ‘imali’ has been recognized in different system of traditional medicines for the treatment of different diseases and aliments of human being. This review supports of all updated information on its pharmacognostical, pharmacological activity and traditional uses. Preliminary phytochemical screening of this plant revealed the presences of, flavonoids, steroid, glycoside alkaloid and Triterpenoids. It has been reported as Anti-helminthic, antimicrobial, antiseptic, antiviral, asthma, astringent, bacterial skin infections, constipation (chronic or acute), and diabetes. There is no report available on isolated constituents of bioactive compound from plant bark of Tamarinds indica which supports it’s further to isolating a useful pharmacologically active compound as a...
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Posted by admin on Nov 1, 2011 in |
The present study was to investigate the anti-obesity effects of the freeze dried powder of ethanolic extract of Licorice (Glycyrrhiza Glabra) (LP) in a rat model of high-fat diet induced obesity and hyperlipidemia. Male wistar rats were fed with a high-fat diet for 8 weeks to induce obesity and hyperlipidemia. High fat diet induced obese rats exhibited increases in body weight gain, adipose tissue mass and levels of serum glucose, triglycerides and total cholesterol compared to rats fed a normal chow diet. However, administration of LP (100-400 mg/kg, o.d., p.o) along with high-fat diet for 8 weeks significantly reduced high fat diet-induced increases in body weight gain and adipose tissue mass in a dose dependant manner. Moreover, LP attenuated high fat diet induced increased levels of serum glucose, triglycerides and total cholesterol. The antiobesity effects of LP were comparable to orlistat, a well reported pancreatic lipase inhibitor. The antiobesity activity of LP appears to be mediated by decreasing dietary fat absorption from the intestine as LP dose dependently attenuated...
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