Posted by admin on Jan 1, 2012 in |
Ibuprofen, a widely prescribed anti-inflammatory and analgesic drug belongs to class II under BCS and exhibit low and variable oral bioavailability due to its poor aqueous solubility. Solid dispersion of ibuprofen in Starch 1500, a modified starch and polyvinyl pyrrolidone (PVP K 30) was investigated to enhance the dissolution rate and to develop ibuprofen tablets with fast dissolution characteristics. The individual and combined (interaction) effects of Starch 1500 and PVP K 30 on the dissolution rate of ibuprofen solid dispersions and tablets were evaluated in a series of 22 – factorial experiments. Solid dispersions and tablets of ibuprofen were formulated employing selected combinations of Starch 1500 and PVP K 30 as per 22 – Factorial design and were evaluated. The individual and combined effects of Starch 1500 and PVP on the dissolution rate of solid dispersions as well as tablets were highly significant (P<0.01). Solid dispersion of ibuprofen in Starch 1500 enhanced the dissolution rate of ibuprofen by 1.40 fold. Addition of PVP K30 to the solid dispersion in...
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Posted by admin on Jan 1, 2012 in |
The ethnomedicinal practices appear to be a part of traditional system of treatment for domestic cattle in remote areas of Nepal. The knowledge of local healers with the utilization of biological resources in various ailments is still survived and is communicated verbally to limited family members. As a result, this knowledge is at threatened stage. Now days, documentation of traditional knowledge is receiving much attention. The study carried out in seven village development committees of Morang district concerns with the traditional uses of crude drugs obtained form 37 plant species belonging to 24 families which are used for the treatment of 21 common ailments of domestic cattle. Participatory Rural Appraisal (PRA) method was applied to collect the data. The information on the correct botanical sources, family, local name, plant part used, method of preparation and method of application of different crude drugs were investigated in this...
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Posted by admin on Jan 1, 2012 in |
This paper describes the study to measure the sensitivity and accuracy of two techniques, chromatography and spectrophotometry for the direct determination of citalopram in pharmaceutical formulations. Chromatography was performed on SE-30 column (1 m × 3 mm i.d) using Nitrogen as a carrier gas (flow rate of 40 ml/min), having retention time of 12.8 min. Calibration curve was found linear in the range of 200-400 µg/ml. LOD and LOQ values were found as 1.1726 µg/ml and 3.5535 µg/ml respectively and the recoveries were in the range of 98.36–100.07%. In...
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Posted by admin on Jan 1, 2012 in |
Most of the traditional systems of medicine are effective but they lack of standardization. So there is need to develop standardization technique. Central Council for Research in Ayurveda has given preliminary guidelines for standardization the conventionally used formulations. Standardization of herbal formulations is essential in order to assess the quality of drugs, based on the concentration of their active principles, physical and chemical standards. This article reports on standardization of Yakrita Plihantak Churan a polyherbal Ayurvedic formulation used as hepatoprotective. Samples were collected from local market and were subjected standardized on the basis of organoleptic properties, physical characteristics, and physic-chemical evaluation. Microscopic characterization was compared with authentic ingredients as a reference. It was observed that commercial sample from market matched exactly with that of authentic standards after performing the standardization. The set parameters were found to be sufficient to evaluate the studied churn can be used as reference standard for the quality control/assurance...
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Posted by admin on Jan 1, 2012 in |
Fruits of the plant were air dried for several days and cut into small pieces, which were subjected to oven dried for 24 hours at 45-50°C to effect further chopping. Cold methanol extract of fruits were subjected to acid-base treatment to separate the alkaloids. The treated extract was subjected to column chromatography to isolate the pure compound. The xanthine alkaloid, 1, 3, 7-trimethyl-1H-purine-2, 6 (3H, 7H)-dione, caffeine (compound 1) and also p-anisaldehyde (compound 2) were isolated from the column fraction of this ‘alkaloid containing residue’ by elution with ethyl acetate/10% methanol and ethyl acetate/50-100% methanol, respectively. The isolated pure compounds were identified by extensive spectral (1H-NMR, 13C-NMR, DEPT, HMBC, HSQC, Mass) data analysis. Greshoff isolated an alkaloid, pithecolobin from the bark, which is saponin like in its action. Wehmer stated that the seeds also contain pithecolobin. In the Philippines, a decoction of the inner bark (fresh cambium) and the fresh leaves of this tree is used in diarrhea. All these above mentioned study lead us to work on...
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