Posted by admin on Nov 1, 2011 in |
Solid lipid nanoparticles (SLNs) have been proposed as suitable colloidal carriers for delivery of drugs with poor bioavailability. The objective of this study was to develop and evaluate solid lipid nanoparticles of Cefpodoxime Proxetil (CP) for enhancement of bioavailability via its lymphatic absorption. Solvent evaporation technique was adopted to prepare Cefpodoxime Proxetil loaded SLN with Precirol ATO 5 as a carrier with narrow size distribution. The mean particle size, drug entrapment efficiency (%), zeta potential and long term physical stability were investigated in detail. Drug release from Cefpodoxime Proxetil- Solid lipid nanoparticles (CP-SLN) was studied using a Franz diffusion cell. A pharmacokinetic study was conducted on male rats after oral administration of CP and CP-SLN. It was found that the relative bioavailability of CP with SLNs was significantly increased as compared with oral CP suspension. FTIR and DSC study revealed that drug is completely encapsulated in lipid matrix. Dry powder for reconstitution was selected as dosage form for the oral administration of CP-SLNs. These results indicated that bioavailability of...
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Posted by admin on Nov 1, 2011 in |
The objective of the present study was to prepare and evaluate matrix microspheres system for simultaneous and sustained release of candesartan cilexetil and captopril for the management of nephritic syndrome, Ethyl cellulose was used as a retardant polymer and IR study showed better compatibility of it with both the drugs, the matrix microspheres were prepared by emulsion solvent evaporation method and the prepared microspheres were characterized for morphology, drug loading and micromeretical properties. The drug release was performed in pH-6.8. The prepared microspheres were spherical in shape and free flowing in nature, the drug loading capacity ranges from 62-86%, the matrix microspheres show extended release up to 6-8 h, thus, the matrix microspheres have a potential for the prolongation and simultaneous release of candesartan cilexetil and captopril for mitigation of nephritic...
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Posted by admin on Nov 1, 2011 in |
Aim: To study In-Vitro sensitivity of Amphotericin B, Itraconazole and Fluconazole -Resistant against Candida albicans. Methods and Results: A panel of 14 clinical isolates of Candida albicans was tested. Strains were labeled and given a unique identification number. Candida albicans ITCC 4718 were included as quality control organisms in each set of experiments. Interactions in vitro between Amphotericin B, Itraconazole, Voriconazole, and Fluconazole against Itraconazole-resistant Candida albicans clinical strains were determined. Fluconazole and Voriconazole exhibited the most potent interactions with synergy against at least 50% of isolates, and the average fractional concentration index was 0.38 Conclusion: Fluconazole and Voriconazole exhibited the most potent interactions with synergy against isolates and Antagonism was not found for any combination. Significance and Impact of the Study: Fungal infections are frequently tricky to manage prudence has to be exercised in the use of antifungal drugs to capture any additional increase in the...
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Posted by admin on Nov 1, 2011 in |
A series of five membered heterocyclics was synthesized by the reaction between refluxing 2 – furoic acid with ethanol and conc. H2SO4. The obtained ester (2) with hydrazine hydrate and ethanol was refluxed to give hydrazides (3). Reaction of hydrazides (3) with different aromatic acids using phosphorousoxy trichloride (POCl3) lead to the formation of 2-Aryl -5-furyl -1, 3, 4-oxadiazoles [DM (1-6)], and was tested for their antioxidant activity. The synthesized compounds were characterized by IR, 1HNMR and Mass Spectroscopy. All the compounds were screened for in vitro antioxidant activity by DPPH method and nitric oxide scavenging assay. Among the synthesized compounds DM-1, DM-2 and DM-4 were found to be promising compounds of the series substituted with electron donating groups like methoxy and hydroxyl showed higher antioxidant...
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Posted by admin on Nov 1, 2011 in |
Comparative pharmacognostic and phytochemical studies are the reliable source to identify the genuine raw drug from its adulterants. This paper deals with the characterization of the repute ayurvedic drug hallakam from its substitute/adulterants. Ayurvedic experts equated rhizomes of Kaempferia rotunda L. of Zingiberaceae as hallakam and in certain market samples Lagenandra toxicaria Dalz. is also sold as hallakam. The distinguishing pharmacognostic and phytochemical characters evolved from the study help to detect the genuine and market adulterant of...
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