Posted by admin on Oct 1, 2011 in |
A simple and cost effective spectrophotometric method is described for the determination of febuxostat in pure form and in pharmaceutical formulations. The drug was highly soluble in methanol so it was selected as the solvent system for the drug. This ensured adequate drug solubility and maximum assay sensitivity. The linearity range for febuxostat at its wavelength of detection of 315 nm was obtained as 0.2–15 µg/ml.The linear regression equation obtained by least square regression method, were Y =0.0802.X + 0.0036, where Y is the absorbance and X is the concentration (in µg/ml) of pure drug solution. The absorbance was found to increase linearly with increasing concentration of febuxostat, which is corroborated by the calculated correlation coefficient value of 0.9999. The limit of detection and limit of quantification was found to be 0.1743 µg/ ml & 0.5281 µg /ml respectively. The validity of the described procedure was assessed. Statistical analysis of the result shows high accuracy and good precision. The proposed method was successfully applied to the determination of febuxostat...
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Posted by admin on Oct 1, 2011 in |
The objective of present study is to evaluate the anti ulcer activity of ethanol extract of leaves of Heliotropium indicum. The ethanol extract of H. indicum was investigated for its anti ulcer activity against Aspirin plus pylorus ligation induced gastric ulcer in rats, HCl –Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats. The antiulcer activity was assessed by determining and comparing gastric volume, free acidity and ulcer inhibition in aspirin plus pylorus ligation induced gastric ulcer model. The number of lesions in HCI-Ethanol induced peptic ulcer model and mean score value of ulcer inhibition in water immersion stress induced ulcer model. A significant antiulcer activity of plant extract was observed in all the models. Pylorus ligation model showed significant reduction in gastric volume, free acidity and ulcer index as compared to control. Also extract showed significant ulcer inhibition in HCl- Ethanol induced ulcer and ulcer protection index in stress induced ulcer. This present study indicates that Heliotropium indicum leaves extract have potential anti ulcer...
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Posted by admin on Oct 1, 2011 in |
Caesalpinia pulcherrima (Linn.) Popularly known as Peacock flower in India belongs to family Caesalpiniace. The objective of the present work was to evaluate the in-vitro antimicrobial potency of the ethanolic and aqueous extract of Caesalpinia pulcherrima (Linn.) flower (CPF) using agar plate disk diffusion method against Escherichia coli, bacillus subtilis and streptococcus aureus. Cephalosporin (5µg/ml) use as a Standard drug. Results were subjected to minimum inhibitory concentration assay by two fold dilution method. Ethanolic extract of Caesalpinia pulcherrima was more effective against Escherichia coli, bacillus subtilis than aqueous extract and cephalosporin. While in case of streptococcus aureus aqueous extract is more effective than ethanolic extract and cephalosporin. Thus, the present study demonstrate that the traditional claim of Caesalpinia pulcherrima (Linn.) flower as an antimicrobial has been confirmed as the aqueous and ethanolic extracts displayed activity against the different microorganism used in...
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Posted by admin on Oct 1, 2011 in |
Objectives: To develop an integrated industrial production and quality control layout which facilitates the pharmaceutical industries for manufacturing, controlling quality of various types of pharmaceutical formulations in a single production unit. Methods: For designing the integrated process layout for the production and quality control, different operations and their sequences involved in the manufacturing and official tests to be met by various formulations had been considered respectively for achieving an efficient and effective movement of material and people. Results: An ideal integrated industrial process layout for the production and quality control of various pharmaceutical formulations had been developed. Conclusions: In the current marketing trend it is necessary for the manufacturer to shift from single line production layout to multi-product production (integrated) layout to maintain several types of formulations (product mix) to make his presence and sustaining in the market with involvement of...
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Posted by admin on Oct 1, 2011 in |
The purpose of the study was to improve the physicochemical properties of Mesalamine like solubility and dissolution rate by forming solid dispersions with sodium lauryl sulphate (SLS) and Urea (UR) as water-soluble carriers. The solid dispersion of Mesalamine by kneading method were prepared using 1:1, 1:2 and 1:3 ratios of drug to polymer using methanol as solvent. Characterization of Mesalamine solid dispersion was performed by Fourier Transform Infrared (FTIR) spectroscopy and X-ray powder diffractometry study. FTIR spectra reveal that there was no drug – carrier interaction and absence of Mesalamine peaks in XRD profile suggests the transformation of crystalline Mesalamine to amorphous form. The saturation Solubility study was carried out by using flask shaker method at room temperature. Dissolution study was conducted in 0.1N HCl at 37oC ± 0.5oC using USP type II (paddle) type dissolution apparatus. The prepared dispersion showed marked increase the saturation solubility and dissolution rate of Mesalamine than that of drug alone. Therefore the dissolution rate of poorly water soluble drug Mesalamine can be significantly...
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