Posted by admin on Jan 1, 2012 in |
The present study is aimed at evaluating the in vitro antibacterial and antifungal activities of petroleum ether, chloroform, ethyl acetate, acetone, methanol, ethanol and water extracts of medicinal plant, Pyrus pashia were tested against (different gram positive and gram negative) ten bacterial strains and three fungal strains using by disc diffusion method. The different fractions of bark, fruit and leaf of Pyrus pashia, the ethanolic bark extracts of Pyrus pashia showed significant activity 17±1mm, 15±1mm and 14±1mm against Klebsiella pneumonia, Shigella flexneri and Escherichia coli. The medicinal plant fruit contain ash value, (total ash 1.10 ± 0.05%), moisture 60.36±0.25%, crude fat 1.62±0.20% and crude fiber 5.26±0.05%, extractive values were studied fresh part weight. The preliminary phytochemical analysis test showed the presence of carbohydrates (28.38±0.12%) and glycosides, alkaloid, flavonoids, saponins, tannins, unsaturated triterpenoids and sterol,...
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Posted by admin on Jan 1, 2012 in |
The world health organization estimates that a staggering 2 billion people harbor parasitic worm infections. Parasitic worms also infect livestock and crops, affecting food production with a resultant economic impact. Development of anthelmintic resistance and high cost of conventional anthelmintic drugs led to the evaluation of medicinal plants has an alternative source of anthelmintics. In view of this, an attempt has been made to study the anthelmintic activity of whole plant of Cissampelos pareira. The activity was checked by in-vitro anthelmintic model by using earthworm. In this current study, alcoholic and aqueous extract at various concentrations (5, 10, 25, 50, 100 mg/ml) were used and studied for paralysis and death of earthworm. All the extract was found not only to paralyze (Vermifuge) but also to kill the earthworm (vermicide). All the extract have significant activity but aqueous extract (100mg/ml) was found to be more effective to execute the earthworm. From this study it is concluded that Cissampelos pareira have potent anthelmintic activity and can be used in the treatment...
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Posted by admin on Jan 1, 2012 in |
According to classical texts Paederia foetida is used as the genuine source plant of the drug Prasarini, it posses properties like astringent, aphrodisiac, laxative, bitter etc. In Ayurvedic practitioners Merremia tridentata ssp. tridentata and Merremia tridentata ssp. hastata are used as the source plant of this drug. However no conclusive pharmacognostic study of these plants has been performed yet. The present investigation deals with the comparative study of morphological, anatomical, histochemical and phytochemical characters of these three plants. Three plants show similarities and differences between them at morphological, anatomical, histochemical and phytochemical levels. Anatomically these three plants show differences in many characters. But phytochemical studies revealed that these plants show much similarity.b– sitosterol was present in all the three plants but their concentrations shows differences. The parameters used in this study will help to identify the genuine and substitute source plants of the drug prasarini for the preparation of ayurvedic medicines and to ensure the quality of...
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Posted by admin on Jan 1, 2012 in |
The objective of the present study to develop controlled release tablets of Metoprolol succinate using Natural polymer, guar gum and synthetic polymer, carbopol as a rate controlling polymers.. It was also desired to study the effect of polymer concentration. Metoprolol succinate, β1- selective adrenergic receptor- blocking agent used in the management of hypertension, angina pectoris, cardiac arrthymias, myocardial infarction, heart failure, hyperthyroidism and in the prophylactic treatment of migraine. The half-life of drug is relatively short approximately 4-6 hrs and in normal course of therapy drug administration is required every 4-6 hrs, thus warrants the use of controlled release formulation for prolong action and to improve patient compliance. In the present investigation Natural polymer, guar gum and synthetic polymer, carbopol have been selected as matrix forming materials for the drug. The formulations are made by employing the conventional wet granulation method, to achieve prolonged release of...
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Posted by admin on Jan 1, 2012 in |
The objective of the present study was to prepare and evaluate gastroretentive floating drug delivery system containing famotidine as a model drug. Famotidine tablets were prepared by wet granulation method using two different grades of hydroxypropylmethyl cellulose- HPMC K4M and HPMC K100M by effervescent technique. Sodium bicarbonate (SB) and citric acid (CA) were incorporated as gas-generating agents. Floating tablets were evaluated for uniformity of weight, thickness, hardness, friability, drug content, in vitro buoyancy and dissolution studies. The effect of effervescent agent on drug release profile and floating properties was also investigated. Prepared tablets exhibited controlled and prolonged drug release profiles while floating over the dissolution medium. Non–Fickian diffusion was confirmed as the drug release mechanism from these tablets, indicating that water diffusion and polymer rearrangement played an essential role in drug release. All the prepared tablets showed good in vitro...
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