Posted by admin on Dec 1, 2011 in |
A simple, specific, accurate and precise reverse phase high performance liquid chromatographic method was developed and validated for the estimation of Itraconazole in capsule dosage form. An inertsil C-18, 5μm column having 250 x 4.6mm internal diameter in isocratic mode with mobile phase containing Tetrabutyl ammonium hydrogen sulphate buffer solution and Acetonitrile in the ratio of 40:60v/v was used. The flow rate was 1.5ml/min and effluents were monitored at 225nm. The retention time for Itraconazole was 5.617min. The method was validated for linearity, accuracy, precision, specificity, limit of detection, limit of quantification and robustness. Limit of detection and limit of quantification were found to be 0.85μg/ml and 2.60μg/ml respectively and recovery of Itraconazole from capsule formulation was found to be 98.3 to 100.3%.The system suitability parameters such as theoretical plates and tailing factor were found to be 2927.43 and 1.08 The proposed method was successfully applied for the quantitative determination of Itraconazole in capsule...
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Posted by admin on Dec 1, 2011 in |
The objective of the current investigation is to reduce dosing frequency and improve patient compliance by designing and systematically evaluating sustained release microspheres of verapamil. Frequent administration and variable low bioavailability (40-60%) after oral administration are problems of conventional dosage forms of verapamil can be attenuated by designing it in the form of mucoadhesive microspheres which would prolong the residence time at the absorption site to facilitate intimate contact with the absorption surface and thereby improve and enhance the bioavailability. Verapamil-loaded mucoadhesive microspheres were successfully prepared by emulsification-internal gelation technique with a maximum incorporation efficiency of 93.29±0.26%. The scanning electron microscopic study indicated that the microspheres were spherical in shape and the drug remained dispersed in the polymer matrix at amorphous state, which was further confirmed by x-ray diffraction analysis. The in vitro wash-off test indicated that the microspheres had good mucoadhesive properties. The wash-off was faster at simulated intestinal fluid (phosphate buffer, pH 7.4) than that at simulated gastric fluid (0.1 M HCl, pH 1.2). The in vitro...
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Posted by admin on Dec 1, 2011 in |
Background: An excessive medical expenditure is becoming a main barrier to good health for several people in China. Hence, there is a need to control this rising medical cost to reduce the financial burden placed on family and society in general. Objective: Our aim was to understand the expenses incurred during the use of two forms of infusion therapy- the premixed preparations and the freeze-drying powder forms and help select a safe and in-expensive route. Methods: The study was based on a drug named Metronidazole which comes in both the forms mentioned above and which is being successfully used for years in Chinese hospitals. Various parameters were taken into consideration to determine the costs involved during the treatment such as the actual price of the drug, duration of the treatment, the preparation costs, labor charges, materials involved in the preparation, medical waste disposal, equipment and maintenance expenses, size of the hospital and the energy costs. Results: Overall, our results revealed that premixed form of Metronidazole is not just a...
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Posted by admin on Dec 1, 2011 in |
The transition in diet has lead to an increase in lifestyle disorders and thereby increased dependency on wonder drugs. With increased drug discovery and marketing, there is a compelling trend towards large drug dosage. However, food is judged not only for its nutritive properties but also for its ability to improve the health and well being of consumers, thus leading to the advent of “FUNCTIONAL FOODS”. Probiotic organisms of the gut and prebiotics are two under explored functional foods. Hence the current study was done with the aim of formulating a synbiotic health drink to enhance the intestinal flora. Dietary prebiotic sources like whole wheat, oats, soyabean, samai and artichoke were used in the preparation of the health drink. Whole wheat, samai and soyabean was malted separately, shade dried and powdered. Standard procedure was followed while preparing artichoke powder. All the selected ingredients were blended together along with one gram of lyophilized vacuum dried lactic acid bacillus. Six variations of the drink was prepared and organoleptically evaluated to find...
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Posted by admin on Dec 1, 2011 in |
Clopidogrel Bisulphate is an oral, thienopyridine class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. Immediate release tablet of clopidogrel bisulphate (form II) was prepared by using direct compression technique. Clopidogrel Bisulphate is very hygroscopic and show rapid degradation when processed with alkali salt as Mg++, Ca++ etc picking, sticking, or other kind of surface irregularities are other processing problems associated with it so, selection of excipients were done for preparation of stable dosage form which was free from any surface irregularities. Lubricants used were hydrogenated castor oil and poly-12-hydroxy...
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