Posted by admin on Sep 1, 2011 in |
This study was designed to present the observation of the pharmacological properties to the bulb of the plant. The extract of the bulb of Urginea indica Kunth. were collected by using of alcoholic extraction. The anti-inflammatory action of the alcoholic Extract of the bulb of the plant Urginea indica was evaluated in rats (female) against carrageenan induced edema i.e., using plethysmographic method. Besides this method, this extract was also assessed for Cotton pellet test and Hot plate test for anti-inflammatory and analgesic effects respectively. The effects of the extract were compared with the classical anti-inflammatory drug – Ibuprofen. The crude extract and the standard drug were orally administered. A significant anti-inflammatory effect was produced with the Alcoholic Extract of the plant part. This effect was then compared with the effect from the classical anti-inflammatory...
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Posted by admin on Sep 1, 2011 in |
Cordia dichotoma known as lasura, lisora, is a commonly known herb in Indian system of medicine to treat various disorders including diabetes mellitus without any scientific evidences. Therefore this study was designed to investigate in vivo hypoglycemic and antidiabetic potential of methanol extract of fruits of Cordia dichotoma in glucose loaded animals and alloxan induced diabetic animals. In both the models Cordia dichotoma reduce the blood glucose level when compared to diabetic control group and exert a significant hypoglycemic and antidiabetic activity. However the potency of the herb was less than that of standard drug metformin. Cordia dichotoma methanol extract also reduced the rate of body weight loss in normal and alloxan induced diabetic animals. The results of this study revealed the presence of a significant antidiabetic potential of methanol extract of Cordia dichotoma in alloxan induced diabetic rats. On the basis of this further research work is needed to investigate exact mechanism of action and also to isolate the active constituent/s responsible for the...
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Posted by admin on Sep 1, 2011 in |
The present study was designed to investigate in vivo analgesic and cytotoxicity as well as in vitro antibacterial activities of the methanol: ethylacetate (1: 9) extract of the flowers of Peltophorum pterocarpum. Analgesic activity was assayed by acetic acid induced assay method wherein the extract showed moderate activity in a dose dependent manner. In respect of in vivo cytotoxicity, the flower extract of Peltophorum pterocarpum showed moderate activity with 30% cell growth inhibition against Ehrlich Ascites Carcinoma (EAC) cells at a dose of 50mg/kg. Moreover, Antibacterial test were done against five Gram-positive and four Gram-negative bacteria. Flower extract was active against all tested microbial species except Staphylococcus aureus and the zone of inhibition range was found to be 12±0.32 to 18±0.11...
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Posted by admin on Sep 1, 2011 in |
Purpose: The aim of this study was to enhance the dissolution rate of Cyclosporine A, a poorly water-soluble drug by developing a self micro-emulsifying (SME) tablet formulation by using the liquisolid compact technique. A liquisolid system is formed by converting a liquid formulation into a dry, free-flowing and compressible powder mixture with selected carrier material and coating material. This technique has industrial applications for low dose insoluble drugs. Method and Results: The solubility of Cyclosporine A (BCS ClassⅡdrug), as a model drug in this study, was determined in several oils, surfactants and co-surfactants using an HPLC method. The self micro-emulsifying system of Cyclosporine A was constructed by using Maisine 35-1 and Lauroglycol FCC (1:1, w/w, oil phase), PEG-35 Castor Oil (surfactant) and PEG 400 (co-surfactant). The ratio of these components in the formulation was 20:50:30 (w/w) and optimized by a pseudo ternary phase diagram. The droplet size of the optimized liquid with drug was 32.9±0.1nm. The stability experiment results showed the model drug in the micro-emulsifying system was stable...
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Posted by admin on Sep 1, 2011 in |
Analytical methods employed for the determination of drugs and metabolites in biological matrices such as urine, plasma and serum are essential throughout drug discovery and development. It is well-known that, analytical techniques are constantly undergoing change and improvements and each analytical method has its own characteristics which may vary from analyte to analyte at different conditions. As the drug continues through development, the decisions become more critical; therefore, the bio-analytical methods that produce the data should be accurate. In the present study, we have developed a simple, precise and reproducible liquid chromatography tandem mass spectrometry method and validated according to FDA-GLP guidelines for quantification of Omeprazole in human plasma using Lansoprazole as internal standard utilizing LC-MS/MS incorporated with quadrapole mass spectrometer utilizing electrospray ionization technique. Samples were analyzed for Accuracy, Precision, Sensitivity, Selectivity, Recovery, stability and accuracy of method by injecting spiked matrix (human plasma) in to LC-MS/MS. The method specificity was determined by analyzing six different batches of human plasma to check the chromatographic conditions from endogenous plasma...
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