Posted by admin on May 31, 2023 in |
Infectious diseases continue to be a major cause of morbidity and mortality, and the current antimicrobial resistance crisis has the potential to worsen this problem. To address this issue, new antimicrobials and strategies for fighting antimicrobial resistance are needed. In this study, we synthesized two arylflouro hydrazide derivatives by reacting various selected hydrazides (4-Fluorobenz-hydrazide) and different substituted aromatic aldehydes (3-Bromo-2-fluoro benzaldehyde and 5-Bromothiophene-2-carboxaldehyde). The compounds were characterized using IR, 1H NMR, and 13C NMR. The synthesized derivatives were also pharmacologically evaluated using molecular modeling. The biological activity was assessed using an antimicrobial assay, which showed significant activity compared to the standard Ampicillin. Among the synthesized compounds, PD2B exhibited a higher zone of inhibition with 10 mm in E. coli and 12 mm in B. subtilis, whereas PD2F showed a zone of inhibition with 3 mm in E. coli and 8 mm in B....
Read More
Posted by admin on May 31, 2023 in |
Purpose: Sanshamani Vati (SHV) is useful in all types of Jwara, and Mahalaxmivilas Rasa (MLVR) is the best drug in various cardiovascular and respiratory disorders. To maintain the enormous trust in Ayurveda, it’s necessary to ascertain the quality, efficacy & safety of Ayurvedic formulations on scientific lines using modern techniques. Present work attempts have been made to standardize the traditional Ayurvedic formulations – SHV and MLVR with modern techniques. Method: The formulations were standardized for physicochemical, Elemental and phytochemical screening. The XRD profiling was done for MLVR. Also the authentication of RM used in SHV was done using HPTLC. The validation of the methods for Elemental and phytochemical assays was performed as per ICH guidelines. Results: The Physico-chemical and phyto-chemical screening of Sanshamani Vati, and Mahalaxmivilas Rasa Tablets was done. The HPTLC profile confirms the presence of Berberine at Rf 0.25 ± 0.02 in SHV and Myristicin at Rf 0.50 ± 0.02 in MLVR. The elemental content of Gold (Au), Iron (Fe), Mercury (Hg) & Copper (Cu) in MLVR...
Read More
Posted by admin on May 31, 2023 in |
Siddha medicine originated from Tamil culture in southern India. Worldwide there are 75% of herbal plants are used for AYUSH and Allopathy medicines. Amukkara Choornam is a polyherbal Siddha formulation. Amukkara Choornam has anti-arthritic activity, and it helps to cure rheumatoid arthritis. The demand for Siddha medicines in India is increasing daily; we have to overcome some problems like quality control issues, processing, administrative issues, and clinical trials. From the above, quality control issues are the most important ones. The quality, safety and, side effects, knowledge about herbs can be determined while standardizing each herbal formulation. The knowledge about the herbs and herbal medicines by the villagers and tribes is unknown to scientists. Scientists are well-known about the standardization process unknown by rural peoples and tribes. Hence the present study is carried out to identify the bioactive phytochemical constituents present in Amukkara Choornam by spectroscopic analysis. Standardization is a tool in the quality control process must for rural health care. Siddha medicines are our traditional medicines, which have lesser...
Read More
Posted by admin on May 31, 2023 in |
In the present investigation, newly developed solid dispersion technology that precludes the use of organic solvent and decreases the individual concentration of hydrotropic agents, simultaneously decreasing their toxic potential, was employed for preparing dispersions of valsartan. Valsartan is a pro-drug which has poor bioavailability because of poor solubility as it belongs to BCS class II. Study aims to enhance the solubility of valsartan by mixed solvency approach. Solution was made by using different co-solvents to enhance the solubility of valsartan. Camphor, thymol were used as solvents to increase the solubility of valsartan. A mixture of camphor: thymol (1:1) was selected for solubility enhancement of valsartan. FTIR study did not show any interaction between drug and excipients. Prepared solid dispersions were evaluated for flow properties, XRD, DSC, and SEM were also compressed to form tablets. Dissolution studies of prepared tablets were carried out using USP Type II Apparatus. The stability study for up to one month showed no significant changes by evaluation parameter. It was concluded that the concept of...
Read More
Posted by admin on May 31, 2023 in |
The epidemic of COVID-19 provides various issues for healthcare professionals. Rapid assessment and treatment, vulnerability classification, efficient use of critical care facilities, adequate medications, surveillance, and prompt discharge, are crucial to protect as many casualties as possible. We described different classification techniques of ML (machine learning) to analyze skin-related issues. This research aims to provide adequate skin specialists with a strategic plan to understand that they may diagnose its prospects and problems. In this work, we use well-known ML methods, including DT (Decision Tree), LR (Logistic Regression), SVM (Support Vector Machines), KNN (K Nearest Neighbor), and multi-model (Gradient, gaussian nave bias, XGB, SGD), classification methods. Make an intelligent diagnostic assistant to correctly identify a certain kind of allergy...
Read More
