Posted by admin on Sep 1, 2011 in |
Ethosomal systems are now a days attracting attention of many researchers. This study is designed to observe the effect of penetration enhancers in ethosomal formulations. Ascorbic acid is taken as a model drug; phosphatidylcholine and ethanol are taken for ethosome preparation. Propylene glycol is taken as a penetration enhancer. Ethosomes are prepared by solvent dispersion method with and without penetration enhancer. The drug release profile is compared. Dialysis membrane and human cadaver skin are taken for penetration study. In this study the ethosomes which were prepared by adding penetration enhancers showed better penetration...
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Posted by admin on Sep 1, 2011 in |
A simple, reproducible and efficient spectroscopic method developed and validated for determination of Orlistat in bulk and capsule dosage form. The drug was determined spectrophotometrically at 203 nm using methanol as a solvent. The percentage recovery study of the drug for the proposed method ranges from 100.17-99.53%w/w indicating no interferences of the capsule excipients. Linearity was obtained in the concentration range 10-100μg/ml with correlation coefficient of 0.9982. The result analysis was validated statistically and recovery studies confirmed the accuracy and precision of the proposed...
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Posted by admin on Sep 1, 2011 in |
Mucoadhesive microcapsules of sodium valproate, an anticonvulsant used in the treatment of epilepsy and in migraine, have been prepared from sodium alginate, hydroxypropylmethyl cellulose-K4M, carbopol 934P & sodium CMC using 10% w/v calcium chloride solution by ionic gelation method. Drug: polymer ratios were 1:1 in all the formulations and polymer mixtures employed were 4:1, 5:1, 6:1, 7:1 of sodium alginate: polymer (hydroxypropyl methyl cellulose-K4M, carbopol 934P & sodium CMC). Calcium chloride was used for ionic gelatin and cross linking of sodium alginate molecules. Microcapsules were spherical in shape and of sizes between 798 microns to 952 microns. Carbopol 934P was found most effective in controlling drug release from microcapsules followed by sodium CMC. Drug release found to be best from the formulation developed with carbopol 934P and followed Super case II...
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Posted by admin on Sep 1, 2011 in |
Delivery of the desired drug as mucoadhesives drug delivery systems has been subject of interest since last three decades. The various advantages associated with these systems made the buccal drug delivery as a novel route of drug administration. The oral transmucosal drug delivery bypasses liver and avoids presystemic elimination in the gastro intestinal tract and liver. The present investigation highlights the formulation and evaluation of mucoadhesive buccal films of Ranitidine Hydrochloride. The mucoadhesive buccal films of Ranitidine were prepared by solvent casting technique using polymers like hydroxyl propyl methyl cellulose E15 (HPMC E15) and carbopol 934P alone or in combination. The formulated films were evaluated for their physiochemical parameters like surface pH, percentage moisture absorption, percentage moisture loss, swelling percentage, water vapor transmission rate, thickness, weight of the films, folding endurance and drug content. In vitro release studies were performed with pH 6.8 phosphate buffer solution. The films exhibited controlled release more than 12 h. The best mucoadhesive performance and matrix controlled release was exhibited by the formulation A2...
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Posted by admin on Sep 1, 2011 in |
The aim of the current study was to develop once-daily sustained-release matrix tablets of metoprolol succinate, Selective β1– blocker used in cardiovascular diseases. The tablets were prepared by the wet granulation method. Ethanolic solutions of ethylcellulose (EC), polyvinylpyrrolidone K30 were used as granulating agents along with hydrophilic matrix polymer hydroxypropyl methylcellulose (HPMC K100M). The granules were evaluated for angle of repose, bulk density, compressibility index and drug content. The tablets were subjected to thickness, diameter, weight variation test, drug content, hardness, friability, and in vitro release studies. The granules showed satisfactory flow properties, compressibility, and drug content. All the tablet formulations showed acceptable pharmacotechnical properties and complied with in-house specifications for tested parameters. The results of dissolution studies indicated that batch AH3 (Drug-to-HPMC K100M, ethyl cellulose solution (4%W/V, as granulating agent) could extend the drug release up to 24 hours. Batch AH3 showed highest f2 value 84.95 and MDT 8.9 hrs similar to that of reference product. The dissolution data were subjected to model fitting analysis and best fitted...
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