Posted by admin on Dec 1, 2011 in |
The availability of numerous brands of co-trimoxazole in our local market today places health professionals in a difficult situation of choice of a suitable brand or the possibility of alternative use. The aim of the study was to predict the physicochemical and in-vitro bioavailability equivalence of six brands of co-trimoxazole tablets marketed in Tigray, Ethiopia. Weight uniformity, friability, hardness, disintegration, assay and dissolution profile were performed using methods described in British and United State Pharmacopoeias and all these tablets passed compendial specifications. Statistical analysis (ANOVA) of thickness, weight and disintegration data showed a significant difference (p<0.05) between generic and innovator brands. Similarly, a significant difference was found between the mean % release of trimethoprim (p<0.0002) and sulfamethoxazole (p<0.0001) of the generic and innovator brands at the pharmacopoeia specified time, 60 min. These statistical results indicated that the brands were not equivalent with respect to their in-vitro release profile. All products showed a trimethoprim % release of greater than 85% within 15 min. Model independent approach of similarity factor (f2)...
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Posted by admin on Dec 1, 2011 in |
Safer antioxidants suitable for long term use are needed to prevent or stop the progression of free radical mediated disorders. In this study, the antioxidant activity of hydroethanolic extract of stem bark of Ougeinia oojeinensis (Roxb.) (HEBO) was studied using various in vitro assays. The antioxidant activity of the extract was evaluated by using the free radical scavenging activity assay (DPPH method), reducing power assay. The findings indicated promising antioxidant activity of the hydroethanolic extract of stem bark of Ougeinia oojeinensis (Roxb.) and needs further exploration for its effective use in both modern and traditional system of...
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Posted by admin on Dec 1, 2011 in |
Two simple, sensitive, rapid, accurate and economical methods were developed for the estimation of Metronidazole and Ofloxacin in two component liquid dosage form. First method is based on the simultaneous equation and second method is based on Q-analysis (absorbance ratio method). Metronidazole has absorbance maxima at 318.0 nm and Ofloxacin has absorbance maxima at 294 nm in acetonitrile and diluent(70:30) solvent PH of 9.89. The linearity was obtained in the concentration range of 5-30 μg/ml for Metronidazole and 3-18 µg/ml for Ofloxacin. In the first method, the concentrations of the drugs were determined by using simultaneous equations and in second method, the concentration of the drugs were determined by using ratio of absorbances at isoabsorptive point and at the λ-max of one of the drug. The results of analysis have been validated statistically and by recovery...
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Posted by admin on Dec 1, 2011 in |
Aims: Qualitative analysis of a mucoadhesive polymeric (Carbopol940) suspension of Norfloxacin was carried out with the aim of developing an oral controlled release gastro-retentive dosage form. Methods: The characterization of ultrasonicated formulation was performed by Fourier Transform Infrared Spectroscopy (FTIR), Raman Spectroscopy, X-ray powder diffraction (XRD) and Scanning electron microscopy (SEM) analyses. For interpretation, FTIR (400 cm-1 to 4000 cm-1 region) and Raman (140 to 2400 cm-1 region) spectra were used. XRD data of pure drug, polymer and the mucoadhesive polymeric (Carbopol940) suspension were obtained using a powder diffractometer, scanned from a Bragg’s angle (2θ) of 10˚ to 70˚. In addition, dispersion of particle was studied using SEM techniques. Results: The results from FTIR and Raman Spectroscopic analyses suggested that in the mucoadhesive suspension, carboxylic groups of Norfloxacin and hydroxyl groups of C940 undergo chemical interaction leading to esterification and hydrogen bonding. The XRD data indicated that the retention of crystalline nature of Norfloxacin in the mucoadhesive suspension. Moreover, the SEM image analysis suggested that in the formulation maximum...
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Posted by admin on Dec 1, 2011 in |
The leaf of the plant Lawsonia inermis was examined for analgesic and anti-diarrhoeal properties. From the study of analgesic activity it was found that ethanol extract at a dose of 500 mg/kg exhibited no significant (p<0.3) inhibition of writhing reflex (28.45 % inhibition) while the inhibition of standard drug diclofenac sodium showed 82.7 % inhibition at a dose of 25 mg/kg body weight. The findings suggested that the leaf extract of Lawsonia inermis possessed anti-diarrhoeal activity at the dose of 500 mg/kg body weight compared to the control group and offered about 1.398 of the mean latent period for diarrhoeal episode to ensue and the result was significant...
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