Posted by admin on Oct 1, 2011 in |
The different extracts of the roots of Caesalpinia Bondue (Family- Fabeaccae) were tested for anti-diabetic activity, by glucose tolerance test in normal rats and alloxan induced diabetic rats. Aqueous ethanol and chloroform extracts had shown significant protection and lowered the blood glucose levels to normal in glucose tolerance test. In alloxan induced diabetic rats the maximum reduction in blood glucose was observed after 3h at a dose level of 250 mg/kg of body weight. The percentage protections by aqueous chloroform and ethanol extracts were 22.28 and 23% respectively. In long term treatment of alloxan induced diabetic rats, the degree of protection was determined by measuring blood glucose, triglycerides, cholesterol and urea levels on 0,3,5,7 and 10th day. Both the extracts showed a significant anti- diabetic activity comparable with that of glibenclamide, standard anti-diabetic...
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Posted by admin on Oct 1, 2011 in |
The objective of the present study was to develop once daily controlled-release matrix tablets of Domperidone Maleate, an anti- emetic agent. Several formulations containing an anti- emetic agent (domperidone maleate) and hydrophilic polymers (Hydroxypropyl methylcellulose, Carbopol and Polyethylene oxide) were prepared by wet granulation methods. The tablets were subjected to thickness, diameter, weight variation test, drug content, hardness, friability and in-vitro release studies. All the tablet formulation showed acceptable pharmacotechnical properties and complied with in house speciation for tested parameters. The results of dissolution studies indicate that formulation FH2 (Drug to HPMC, 1:0.50; purified water as granulating agent) could extend the drug release upto 24 hours. All the formulation exhibited diffusion dominated drug...
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Posted by admin on Oct 1, 2011 in |
The aim of present study is to develop a delayed release pellets dosage form of duloxetine hydrochloride with a suitable polymer by using suspension layered method. Drug loaded nuclei was prepared using suspension layered technique in a Fluidized Bed Processor, the nuclei was coated with an acid resistant acrylic polymer (Eudragit L30-D55) and compared acid resistant properties with HPMC phthalate. The entire coating process performed in a Fluidized Bed Processor to different thickness. The in vitro dissolution studies were conducted in 0.1N HCl for 2 hours followed by phosphate buffer (pH 6.8) for 1 hour with USP dissolution tester (type II). The results generated in this study showed that proper selection of polymer material based on their physicochemical properties as well as polymer load is important in designing delayed release pellets dosage form with best fit of dissolution...
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Posted by admin on Oct 1, 2011 in |
Aim: Primary urinary bladder adenocarcinoma is a rare entity. This is a clinical case presentation with review of the literature on this topic. Primary adenocarcinoma of the urinary bladder has shown a poor response to radiation or chemotherapy individually. Therefore, combination chemotherapy with radical EBRT is the effective therapeutic approach for inoperable cases. Method: A 58 year old male patient referred to the department of Radiotherapy, Regional Cancer Centre, Pt. BDS PGIMS ROHTAK with complaints of gross painless hematuria, dysuria, burning micturation for 5 years. Diagnostic work-up included renal and bladder ultrasound, cystoscopy and CT scan of abdomen and pelvis. CT scan showed mass lesion in urinary bladder infiltrating anterior abdominal wall (primary bladder adeno- carcinoma T4bN0M0). Trans-urethral resection followed by tissue diagnosis revealed an invasive adenocarcinoma. Metastatic disease was ruled out. Patient responded completely to systemic combination chemotherapy including GEMCITABINE and CARBOPLATIN six courses followed by radical external radiotherapy. At 24 months of follow-up, the patient did not present disease progression or systemic complications, after that he developed a nodular lump in neck. FNAC of node showed...
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Posted by admin on Oct 1, 2011 in |
The present study was undertaken to determine the anti-ulcer potential of Calamintha officinalis Moench, a standardized oil of Calamintha officinalis Moench, commonly known as Calamint. Effect of various doses (0.4ml/kg and 0.8ml/kg,) of Calamintha officinalis Moench. oil was studied on gastric ulcers in pylorus ligation, Diclofenac sodium induced gastric mucosal injury in rats. Anti-ulcer activity was evaluated by measuring the ulcer index, gastric content, total acidity, and pH of gastric fluid. Calamintha officinalis Moench, dose dependently decreased gastric content, total acidity, ulcer index and increased pH of gastric fluid in pylorus ligation ulcer model. In Diclofenac sodium induced ulcer models, all the doses of Calamintha officinalis Moench. oil decreased the ulcer index and increased the pH gastric fluid. These results supported the ethnomedical uses of oil of Calamintha officinalis Moench. in the treatment of gastric...
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