Posted by admin on Dec 1, 2011 in |
Amaranthus vegetable and seeds are highly nutritious. Four species of Amaranthus were planted in pots in a glass house and leaves were harvested. Fresh leaves were analyzed for protein and carbohydrate content and oven dried leaves for Fe, Ca, K and Na contents. Protein content was varied from 6.10-9.00g/100g of fresh leaves. The amount of carbohydrate in fresh leaves of all four species varied from 9.75g-21.29g. Among the species, A. spinosus showed higher amount (21.29g) which is almost two folds higher than A. tricolor (9.75g). Results showed that A. viridis had higher accumulation (54mg). Overall K amount in the dry leaves of the four species varied between 2230-3900mg per 100 g of dry leaves and it was almost 2 fold differences between values of lowest and highest accumulation. The variation in amount of Ca was 38 fold higher, A. spinosus from the minimum amount (A. blitum). Fe content in dry leaves was maximum in A. viridis (15mg per 100g of dry wt) followed by A. spinosus (13.28mg), A. tricolor...
Read More
Posted by admin on Dec 1, 2011 in |
A rapid and sensitive high performance liquid chromatography method for determination of cetirizine dihydrochloride and ambroxol hydrochloride has been developed. The chromatography system used a reversed phase C-8 column with UV- Vis detection at 230 nm. Mobile phase consisted of acetonitrile – 0.1% triethlamine (50:50 v/v) (pH adjusted to 4.0 using 10% ortho phosphoric acid) at a flow rate of 1.5 ml/min using propranolol as internal standard (I.S.). The calibration curve was linear in the concentration range of 2-20 µg/ml for cetirize dihydrochloride, 24-240µg/ml for ambroxol hydrochloride. The lower limit of detection was found to be 0.06 µg and 0.02µg, for cetirizine dihydochloride and ambroxol hydrochloride...
Read More
Posted by admin on Dec 1, 2011 in |
A new Sulfamethoxazole Schiff base (E)-4-(4-methoxybenzylideneamino)-N-(5-methylis-oxazol-3-yl) benzenesulfonamide (C18H17N3O4S), and its copper complex were synthesized and the structures elucidated on the basis of Physiochemical methods. The studies indicate an octahedral structure for the complexes with the (C22H27N3O10SCu) formula. The IR spectra suggest that the ligand act as tridentate (from oxygen and two nitrogen atoms) donor. Also the biological activity of the Schiff base and its Cu complex were...
Read More
Posted by admin on Dec 1, 2011 in |
The present study was aimed to develop an extended release tablet of Metoprolol Succinate for the treatment of hypertension. Four extended release formulations F1-F4 were developed using varying proportions of Hydroxyl propyl methyl cellulose K100M, Sodium carboxy methyl cellulose and Eudragit L30 D55 by wet granulation. Five extended release formulations F5-F9 containing HPMC K100M and HPMC 5cps in varying concentration were developed by direct compression. The physico-chemical and in-vitro release characteristics of all the formulations were investigated and compared. Two formulations, F7 and F8 have shown not more 25% drug release in 1st h, 20-40% drug release at 4th h, 40-60% drug release at 8th h and not less than 80% at 20th h and the release pattern conform with USP specification for 24 h extended release formulation. It can be conclusively stated that optimum concentration of HPMC K100M (58-65%) by direct compression method can yield an extended release of Metoprolol succinate for 24...
Read More
Posted by admin on Dec 1, 2011 in |
This study is aimed to assess the bioequivalence of five generic ciprofloxacin tablets from different manufacturer using in vitro dissolution study under biowaiver conditions by RP-HPLC. Dissolution media were USP buffer solutions at pH 1.2 (hydrochloric acid solution), pH 4.5 (acetate buffer solution), and pH 6.8 (phosphate buffer solution). Other general quality assessment tests of these tablets like weight variation, hardness, friability, disintegration time and assay were also determined according to established methods. All brands complied with the official specification for uniformity of weight, friability and disintegration time. Assay of selected tablets revealed that all samples contained over 99% (w/w) of labeled chemical content. The dissolution profiles showed no significant inter brand and intra brand variability. Dissolution results of all the tablet formulations and the innovator brand were further analyzed with difference factor (f1), similarity factor (f2), dissolution efficiency and dunnet,s test. These results indicated that all generic ciprofloxacin tablets included in this investigation were bioequivalent with the chosen innovator brand and so may be used...
Read More
