Posted by admin on Feb 1, 2012 in |
This study assessed the level of compliance using three different methods: pill count, self report and peak expiratory flow rate, in asthmatic patients attending a secondary health care facility. Self report (using a pre-tested structured questionnaire), peak expiratory flow rate and pill count were used to assess patient’s compliance and identify the factors which may be responsible for non compliance. Measurement of peak flow rate and the pill count were done at two different occasions. The data obtained was analysed using descriptive statistics. The study showed that the patients were prescribed a range of one to four drugs: 54% (3 drugs), 32% (2 drugs), 8% (4 drugs) and 2% (1 drug). The levels of compliance were 86.57% for self report and 83.56% for pill count (p > 0.05). Reasons given for non compliance were: apparent wellness (33.31%), forgetfulness (26.67%), cost of drugs (6.67%), dysphagia (6.67%), presence of non-disturbing symptoms (6.67%), side effects (6.67%), ignorance/fear of addiction (6.67%), perceived lack of benefit from treatment (6.67%), and lethargy towards chronic medication...
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Posted by admin on Feb 1, 2012 in |
This study was designed to investigate the in vitro anti-oxidant and in vitro anti-inflammatory potential of synthesized 3(Substituted) Chromen-2-one. Anti-oxidant activity has done by DPPH, NO and H2O2 free radical scavenging activity, ascorbic acid was used as a standard. Anti-inflammatory activity has done by membrane stabilization method; aceclofenac sodium was used as standard. The presence of OCH3 group in aromatic ring system of the compound prompted us to evaluate its anti-oxidant and anti-inflammatory activity. Some of the synthesized compounds which contains OCH3 group has been found to be having high anti-oxidant and anti-inflammatory activity by various in vitro...
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Posted by admin on Feb 1, 2012 in |
A simple, accurate, precise and sensitive reverse phase high performance liquid chromatography (RP-HPLC) method for the determination of cefixime trihydrate and its degraded products have been developed and validated. Drug was resolved on a C18 column (waters spherisorb 25 cm × 4.6 mm, 5µm), utilizing mobile phase of sodium dihydrogen phosphate monohydrate (0.1M aqueous) pH adjusted to 2.5 with diluted orthophospharic acid (10 % aqueous) and methanol in a ratio of 3:1 respectively. Mobile phase was delivered at the flow rate of 1.0 ml/min. Ultra violet detection was carried out at 254 nm. Separation was completed within 9.75 minutes. Calibration curve was linear with correlation coefficient (r2) = 0.9996 over a concentration range 10-50µg/ml. Recovery was between 98.84, 100.25 percentage. Method was found to be reproducible with relative standard deviation (RSD) for intra and interday precision of < 1.0 over the said concentration range. The method was successfully applied to the determination of the decomposed products of cefixime trihydrate, it can be very useful and an alternate to performing...
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Posted by admin on Feb 1, 2012 in |
Purpose: The present study was designed to evaluate the phytochemical, biochemical and antimicrobial activity of leaf extracts of Boerhavia erecta and Chromolaena odorata. Methods: The leaves of Boerhavia erecta and Chromolaena odorata were washed with tap water followed by distilled water. The cleaned leaves were shade dried and then made to fine powder by using homogenizer. About 1.0 gram of clean dried leaf was taken along with 10 ml ethanol and mashed well in a homogenizer and filtered, then used for biochemical,phytochemical analysis and antimicrobial activity by using various standard methods. Results and Conclusions: Since, these plants possess many medicinal properties and the results showed that both the plant extracts possessed significant levels of minerals and vitamins. The presence of biochemical constituents and positive antimicrobial activity expertise its medicinal property. Natural products perform various functions, and many of them have interesting and useful biological activities. Boerhavia erecta and Chromolaena odorata are plants which are extensively used in folk medicine....
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Posted by admin on Feb 1, 2012 in |
The objective of the study is to evaluate the individual and combined effects of hydroxy propyl β cyclodextrin (HPβCD), surfactant (Poloxamer 407) on the solubility and dissolution rate of nimesulide, a BCS class II drug in a series of 22 factorial experiments. The solubility of nimesulide in four selected fluids containing HPβCD and Poloxamer 407 as per a 22 factorial study was determined. HPβCD alone gave a marginal increase (1.47 fold) in the solubility of nimesulide. Whereas Poloxamer 407 alone and combination of HPβCD and Poloxamer 407 gave a significantly higher enhancement in the solubility of nimesulide, 2.5 and 6.52 fold respectively. Solid inclusion complexes of nimesulide- HPβCD were prepared with and without Poloxamer 407 by kneading method as per a 22-factorial design. Both the individual and combined effects of HPβCD and Poloxamer 407 on the solubility, dissolution rate and dissolution efficiency (DE30) of nimesulide were highly significant (P < 0.01). HPβCD and Poloxamer 407 alone gave 13.17 and 5.20 fold increase in the dissolution rate of nimesulide. Combination...
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