Posted by admin on Aug 1, 2011 in |
The quality control of herbal drugs and their extracts is essential when they are used as raw material for the development of herbal medicines. In this work, several techniques (pharmacopoeial and non-pharmacopoeial) were performed, aiming at establishing quality control parameters of the leaves of Heliotropium indicum L. (Boraginaceae), a shrub popularly known as stinker (fedegoso) in Brazilian northern and northeastern regions. The results determined the physicochemical characteristics of the drug and the tincture of the leaves. They also showed that the values obtained are in accordance with the data found in the literature for plant material. Preliminary phytochemical analysis of the leaves demonstrated the presence of phenols, tannins and alkaloids. The chromatographic profile showed the presence of a common substance in the hexanic and alkaloidal...
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Posted by admin on Aug 1, 2011 in |
PURPOSE: The aim of this retrospective study is to present data of patient characteristics, treatment patterns, and treatment results in an unselected patient population with small cell lung cancer (SCLC) in limited disease (LD) and extensive disease stage (ED). MATERIAL AND METHODS: All patients of carcinoma lung from April 2007 to December 2009 were analyzed for present study, conducted in department of radiotherapy, PGIMS Rohtak, Haryana. Total diagnosed lung cancer patients found were 531, out of which 41 patients were having small cell lung cancer (SCLC). These patients have been analyzed with respect to patient characteristics, chemotherapy, radiotherapy, and treatment outcome. RESULTS: Twelve (29.27%) of all patients had LD SCLC. Mean age of patient was 58.9 years. Two (5.55%) patient had complete response (CR). Rest 32 (77.77%) patients had partial response. Seven (16.66%) patients did not turn up after treatment. Consecutive thoracic palliative radiotherapy was given in 22 (53.65%) patients. Additional prophylactic cranial irradiation (PCI) was administered to two patients. Sixteen patients (39.02%) received CT with Carboplatin and Etoposide and three (7.32%)...
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Posted by admin on Aug 1, 2011 in |
The fruit extract of C. metuliferus was evaluated for its phytochemical and histopathologic properties. Phytochemical screening showed the presence of alkaloids, flavonoids, tannins, sterols, saponins and cardiac glycosides. The histopathological effects of C. metuliferus fruit extract on the liver, kidney, spleen and pancreas of male adult albinos rats were investigated after daily oral administration for 28 days. The histological examination of rats administered 1000mg/kg of C. metuliferus fruits extract showed focal hepatocellular necrosis similar to that produced by paracetamol overdose. Necrosis of the epithelial cells of the kidney tissues was also observed in rats administered 1000mg/kg of C. metuliferus fruit. These observations suggest that daily oral administration of 1000mg/kg of C. metuliferus fruit extract for 28 days was associated with tissue damage of liver and kidney of the...
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Posted by admin on Aug 1, 2011 in |
In continuing search for compounds with immunomodulatory activity, plant Aralia cachemirica has been found to contain continentalic acid (CA). Isolation of this pharmacologically significant diterpinic acid from Aralia cachemirica is novel. Chemical structure of this compound was identified by spectral analysis as (-)-pimara-8(14), 15-dien-19-oic acid, which has been isolated from A. cordata and A. continentalis. This compound has been evaluated for its effect on immunomodulaion. CA was found to inhibit production of pro-inflammatory cytokines (IL-6, TNF-α) & nitric oxide (NO) in LPS induced macrophage activation, suppressed antibody titres & delayed type hypersensitivity reaction (DTH) when orally administered and increased the phagocytic activity by clearance of Candida albican infection from peritoneal cavity in mouse model...
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Posted by admin on Aug 1, 2011 in |
A simple procedure is reported for the synthesis of Cefotaxime Sodium from an isolable activated ester, diethyl thiophosphoryl [(Z)-(2-aminothiazol-4-yl)-2-(methoxyimino) acetate (DAMA) and 7-ACA (7-Aminocephalosporinic acid). DAMA was synthesized from ATMA [(Z)-2-(2-aminothiazol-4-yl)-2-methoxyimino acetic acid] and DHP [O, O-diethyl O-hydrogen phosphorothioate], which was treated with 7-ACA and chloroform. A 95% pure Cefotaxime acid was obtained; upon further treatment of Cefotaxime acid with 2-ethyl hexanoate, 98.4 % pure Cefotaxime Sodium was obtained. The synthesized material was identified by Infrared spectroscopy & validated High Performance Liquid Chromatographic (HPLC) method and also quantified by HPLC method....
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