Posted by admin on Nov 1, 2011 in |
In this study, a discriminative dissolution method was developed for Cephalexin OD (orally disintegrating) tablets 750mg. The solubility and stability of the cephalexin API was determined in ten different solutions. In that 0.01N HCl, glycine buffer pH 3-0, acetate buffer pH 4.5 and water gave good stability and the solubility. Dissolution profiling of cephalexin OD tablets 750mg of single batch was done with the selected media containing varying concentration of surfactants (tween 80 and Sodium lauryl sulphate- SLS). The release profile is compared with that of the control media. The media that gave discriminately faster release than that of the control were found to be 0.01N HCl with 0.75% of tween 80, 0.01N HCl with 0.5% of SLS, acetate buffer with 1% of tween 80 and water with 0.5% of SLS. With the selected media, dissolution profile was done on the three different batches of cephalexin OD tablets one with lesser polymer ratio and other with higher polymer ratio that that of the test batch. Only 0.01N HCl with...
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Posted by admin on Nov 1, 2011 in |
The stems of Cissus quadrangularis L. (Vitaceae) are reported to have great medicinal value. The present investigation was therefore undertaken to determine the requisite pharmacognostic standards for evaluating the plant material. The macroscopic features of the Cissus quadrangularis L. stem were observed under magnifying lens. Microscopic characters and powder analysis were determined under microscope. The physiochemical properties such as loss on drying, total ash value, acid insoluble ash value, water soluble ash value, pH, and extractive values of stem were carried out. The microscopic study showed abundant large cells of mucilage, clusters and bundles of acicular crystals of calcium oxalate scattered throughout the section. The powder microscopy showed the presence of annular, reticulated and boarded pitted thickening xylem vessels, cluster, rosette and acicular crystals of calcium oxalate and starch grains. Phytochemical analysis showed the presence of many important classes of phytoconstituents like alkaloids, flavonoids, cardiac glycosides and triterpenes. The determination of these characteristics will aid future investigators in their pharmacological analyses of this...
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Posted by admin on Nov 1, 2011 in |
The primary objective of this study is to evaluate the effect of drug loading and the effect of excipients on the release pattern of Dexamethasone Sodium Phosphate from in situ PLGA implants formed in vitro in gelatin gel. This system is prepared by dissolving a biodegradable polymer (DL-PLGA 70K) in dimethyl sulfoxide (DMSO). Then the drug with excipients or without excipients was added to it. When the drug solution poured into the hallow of gelatin gel, the solvent dissipates into the surrounding gelatin base through diffusion leading phase separation & subsequent coagulation of the polymer and the drug to form a rod like implant in situ. Two types of implants were prepared such as implants containing Dexamethasone Sodium Phosphate and implants containing Dexamethasone Sodium Phosphate with biocompatible excipients such as Tween 20, Tween 60, Span 20, Span 80, Chremophore EL, Chremophore RH40, Stearyl alcohol, Cetyl alcohol, PEG 6000, Stearic acid, GMS, Benzyl Benzoate, Magnesium stearate, Dextrose, Lactose and Arachis oil were used. In vitro dissolution studies were performed in...
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Posted by admin on Nov 1, 2011 in |
Dendrimers are synthetic, highly branched, nanosized, monodisperse macromolecule which proving their applicability in different areas like diagnosis, drug delivery, gene delivery, molecular encapsulation etc. Due to their widespread applications, scientific community is continually engaged in developing newer dendrimers with advanced properties. In the present study, amino dendrimers are synthesized according to procedure given in literature and were utilized for its biocompatibility by observing the influence on RBCs. Along with this amino dendrimers were also utilized for their potential in drug delivery by performing solubilization and drug release studies of Methotrexate (MTX). Up to generation third (G3) dendrimers was prepared by divergent method taking PEG as a core which provides homogenesity during synthesis and increases the biocompatibility to biosystem. A preliminary investigation shows that amino dendrimers caused concentration and time dependent haemolysis which is less than that of amino surface dendrimers like PAMAM having no PEG molecules within it. The solubility of MTX increases to 4.68, 5.93, 8.21 and 11.42 folds for the 0.5, 1, 2, 3 mmol concentrations of...
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Posted by admin on Nov 1, 2011 in |
In the present study, an aqueous extract from a marketed mineralo-herbal preparation Reosto was evaluated for its hypocholesterolaemic and hypertriglyceridemic activities using Triton WR-1339 induced hyper- lipidemic rats as experimental model. Hyperlipidemia was developed by intraperitoneal injection of Triton (200 mg/kg body weight). The animals were divided into control (CG), hyperlipidemic (HG), hyperlipidemic plus Reosto extract (200 mg/kg body weight) (HG + ReA), hyperlipidemic plus Reosto extract (400 mg/kg body weight) (HG + ReB) and hyperlipidemic plus Fenofibrate (HG + FF) treated groups. Intragastric administration of Reosto extract to the rats caused a significant decrease on their plasma lipid levels (quantified using enzymatic kits). In Fenofibrate treated rats, lipid parameters were significantly changed indicating that this aqueous extract may contain products that lower plasma lipid concentrations and may be beneficial in treatment of...
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