Posted by admin on Oct 1, 2011 in |
The study was designed to determine the relative bioavailability of two sustained release Fixed dose combination (FDC) products of two manufacturers containing Lornoxicam [CAS No. 70374-39-9] 8mg and Thiocolchicoside [CAS No. 602-41-5] 8mg in 24 healthy male volunteers. The pharmacokinetics of Lornoxicam and Thiocolchicoside individually after oral administration of tablet formulation has been extensively evaluated in adult volunteers. However, no published data are available regarding the combined pharmacokinetics and bioavailability of this particular fixed dose combination. The clinical study was randomized, balanced, open-label, 2-period cross-over study. Each subject was randomized at the beginning of the study to receive either a single dose of test fixed dose combination or reference fixed dose combination during Period I. Following a 7-day wash out period, all subjects received the alternate formulation during Period II. No statistically significant differences were obtained between the two products with respect to the mean concentration-time profiles or in the pharmacokinetic parameters, including area under the serum concentration-time curve from the present study. The relative extent of absorption as...
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Posted by admin on Oct 1, 2011 in |
Aim of the study: Now a days due to the hammering of movies and fashion most of the people specifically age group between 18 to 30 years, are diverted more to have the protein supplements in excess for getting good physique and well toned body shape. The people suppose to eat more calcium, vitamins and some steroids with intension that they will get done the things too fast. Without been having good trainee and medical supervisor most of the people doing exercise in the fitness club and gym and taking the diet which is one of the major cause of nephrotoxicity. Materials and Methods: Ethanolic extract of stem barks of Crataeva nurvula Buch hum in the doses of 200 mg, 400 mg and 600 mg is useful as a laxative, demulcent, stomachic, and is reported to cure disorders of urinary organs. It is also very useful as anti-inflammatory drug and act as a good contraceptive for women and also used in arthritis. Results: In the current study, effects of...
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Posted by admin on Oct 1, 2011 in |
A new, simple, safe, accurate and reproducible spectrophotometric analytical method was developed for the quantitative estimation of gatifloxacin in solid dosage form by mixed hydrotropic agents. The enhancement of solubility of drug gatifloxacin was more than 15 fold in mixed hydrotropic solution (20% N,N dimethyl urea and 20% sodium citrate solution) as compared to solubility in distilled water. Therefore, it was thought worthwhile to solubilize this poorly water soluble drug from fine powder of its tablets by this novel mixed hydrotropic solubilization technique and then carryout its spectrophotometric estimation at 333 nm (20% N,N dimethyl urea and 20% sodium citrate being non-interfering in the estimation). The results of the analysis were validated statistically and by recovery studies & its follows Beer’s law in concentration range of 10-60 mcg/ml. The percent label claims and percent recoveries estimated were close to 100 with low values of standard deviation, percent coefficient of variation and standard error. Thus, the method was accurate providing additional advantage of being cost effective and environment...
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Posted by admin on Oct 1, 2011 in |
Trigonella foenum graecum, (Fenugreek) (Family: Leguminosae) is used as a traditional medicine for anti-inflammatory, antiseptic, antidiabetic and antilipidemic. Hydroalcoholic extract of its seeds were subjected for in vitro antioxidant activity by different methods viz, 1- diphenylpicryl- hydrazyl radical (DPPH), hydroxyl, and ABTS radical cation assay. Total antioxidant capacity, Total phenol and total flavonoid, Total ascorbic acid assay also were estimated. It was observed that free radicals were scavenged by the extract in a dose dependent manner in all the models The content of total phenolics (expressed as mg of gallic acid equivalents/gm) and total flavonoids (expressed as mg of quercetin equivalent/gm) and ascorbic acid were determined along with antioxidant enzymes. The Hydroalcoholic extract of Trigonella foenum graecum, exhibited potent DPPH and ABTS radical scavenging activity with IC50 values of 350µg/ml, and 962.5µg/ml, respectively. The seeds of fenugreek showed significant total antioxidant capacity with IC50 value of 192 µg/ml and hydroxyl radical with IC50 value of 587.5µg/ml, respectively. Based on the results it can be concluded that hydroalcoholic extract of...
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Posted by admin on Oct 1, 2011 in |
In this study, we investigated and compared the total phenolic, alkaloid content and in-vitro antioxidant activity of Leucas aspera collected from four different regions; Tirupathi (Southern zone), Lam (Krishna river region), Jagityala (Northern Telangana) and Hyderabad (Southern Telangana) of Andhra Pradesh, India. Quantitative regional variation was observed in total phenolic content, and alkaloid content in methanolic extracts of Leucas aspera from above four regions of Andhra Pradesh. Concentration dependent antioxidant activity was observed for all these extracts and also observed regional variation for scavenging of Superoxide, Hydroxyl and DPPH radicals. Among the four regions, Leucas aspera from Jagityala region contains more phenolic content (48.06±0.4µg/100 µg), Tirupathi region contains good alkaloid content (58.6±0.1µg/mg) and Hyderabad zone showed better free radical scavenging activity (IC50 value for superoxide radical 156.34µg, Hydroxyl radical 122.34µg and DPPH radical 57.12µg...
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