Posted by admin on Nov 1, 2011 in |
Hypercholesteremia is one of the risk factors for coronary artery disease. The present study highlights the efficacy of Ayurvedic herbal formulation Cynodon dactylon (Bermuda grass) on histopathological study and DNA fragmentation analysis in experimentally induced hypercholesteremic rats. Four groups of rats were employed namely control, hypercholesterolemia rats (4% Cholesterol＋1% cholic acid), Cynodon dactylon treatment in hypercholesteremic rats and Cynodon dactylon alone treated rats. Results of DNA fragmentation was found to be greater in High cholesterol diet fed groups. Lesser fragmentation was found in high cholesterol diet + Cynodon dactylon treated group when compared to the high cholesterol diet group. Cynodon dactylon alone treated group is comparably similar to that of normal group (lesser fragmentation). Histopathological study of thoracic aorta of Cynodon dactylon treated group shows decrease in atherogenicity compared to untreated high cholesterol diet fed rats. The data demonstrated that Cynodon dactylon formulation was associated with hypolipidemic effects on the experimentally induced hypercholesteremic...
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Posted by admin on Nov 1, 2011 in |
In this research work, different blends of superdisintegrants with different ratio in fixed concentration were taken and placebo tablets were formulated and evaluated with a view to optimize a formula and concentration blends of superdisintegrants for Fast Disintegrating Tablets (FDT). In this research work three superdisintegrants, viz. Crosscarmellose, Crospovidone and Sodium Starch Glycolate were used in different ratio (1:1, 1:2, 2:1) in fixed concentration of 4% w/w in combination in each batch. Six blends were prepared and 3 batches of tablets of each formulation code blend were formulated and evaluated for pre-compression parameters like Compressibility, Hausner’s ratio, Bulk density, Tapped density and post-compression parameters like Hardness, Weight variation, Disintegration time, Dispersion time, Friability, Wetting time, Water absorption ratio. Based on results it revealed that the formulation code blend A3 which had Croscarmellose, Crosspovidone in ratio 1:2 (4%w/w) emerged as best blend of superdisintegrants for FDT formulation. To optimize the formula of A3 blend, Paracetamol FDT was formulated and evaluated using the concentration blend of A3; three batches were formulated...
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Posted by admin on Nov 1, 2011 in |
Citrullus colocynthis, belonging to the family of cucurbitaceae. It is a xerophytic desert plant, widely used for its medicinal purpose. In tribal areas it is used for the treatment of constipation, oedema, bacterial infection, cancer, diabetes and abortifacient. Present study is based on developing a protocol for plantlet regeneration from the nodal segment. The sterilized explants were inoculated in different concentrations of cytokinins and auxins. Among the various treatments, MS (1962) medium supplemented with BAP (2.0mg/l) gave the best shooting culture establishment. For shoot elongation MS medium supplemented with IBA (0.1 mg/l) was found to be best. In vitro elongated shoots rooted on MS medium supplemented with IBA (0.1 mg/l). The plantlets were hardened, acclimatized and transplanted in the field, where they showed 60% survival...
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Posted by admin on Nov 1, 2011 in |
The chemical composition of the essential oil of Hyptis suaveolens (L.) leaves from three different regions of Tamil Nadu was analysed by GC – MS method and the constituents of three different localities were compared. In all 12 compounds were identified and they were α-caryophyllene, α-pinene, α-thujene, camphene, D-limonene, sabinene, β-myrcene, 1, 8-cineole, γ-terpinene, α-terpinolene, α-terpineol, phenentherene. It was found that the constituents of the essential oil differed in quantities in the three different populations of Hyptis suaveolens (L.) which may due to local geographical...
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Posted by admin on Nov 1, 2011 in |
In this study, Pleurotus platypus and Pleurotus eous was subjected to identification of bioactive compounds by using Gas chromatography – Mass spectrum technique. These two organisms were extracted with 99% of ethanol. Extracted sample was injected, according to the retention time and peak formation the bioactive compounds are screened. In Pleurotus platypus Pyridine-3-carboxamide, 4-dimethylamino-N-(2, 4-difluorophenyl), Piperidin-4-carboxylic acid, Aspidofractinine-3-methanol, (2à, 3á, 5à), Indolizine, and 2-(4-methylphenyl)-. Pleurotus eous shows that Imidazolidine, 1, 3-dinitro, Phenol, 2-methyl-4-(1, 1, 3, 3-tetramethylbutyl), Aspidofractinine-3-methanol, (2à, 3á, 5à) and Squalene. Pleurotus platypus and Pleurotus eous were subjected to analysis the water soluble – Vitamin B and Fat soluble vitamin A, D, E and K was analysed in High Performance Liquid Chromatography technique. According to the results P.platypus shows the high content of vitamin E and...
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