Posted by admin on Jun 1, 2011 in |
For many decades treatment of an acute disease or a chronic illness has been mostly accomplished by delivery of drugs to patients using various pharmaceutical dosage forms including tablets, capsules, pills, suppositories, creams, ointment, liquids, aerosols and injectables as drug delivery systems are the primary pharmaceutical products commonly seen in the market. In the past two and a half decades several advancements has been made in the pharmaceutical products. They have resulted in the development of new techniques for drug delivery1. These techniques are capable of controlling the rate of drug delivery, sustaining the duration of therapeutic activity and targeting the delivery of drug. A series of three different trial formulation of Rabeprazole Sodium, Microsphere using Chitosan an aminopolysaccharide, so as to optimize the sustained conditions. In the case of microsphere, the initial formulation was done with 0.5% Chitosan solution and drug. Then the concentration of chitosan had been increased to 1.5%. It showed that the percentage release was maximum 65.2% for the chitosan microsphere in the formulation F3,...
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Posted by admin on May 1, 2011 in |
As the psychotic, pediatric and geriatric patients are unable to swallow the medicine mouth dissolving drug delivery systems are designed for rapid dissolution and absorption of drug in the mouth within minutes without the need of water or chewing. Olanzapine is water insoluble drug hence to make it solubilize it is formulated as drug- polymer inclusion complex by using. The aim of the present study was to formulate olanzapine orodispersible tablets by using β-cyclodextrin and superdisintegrants to enhance the solubility of the drug. The drug, polymer and inclusion complex were investigated for drug interactions, complex formation and change in crystallinity by using infrared, differential scanning calorimetry, x-ray diffraction and the tablets were developed by using the direct compression and were investigated for in-vitro dissolution behavior and drug content. β-cyclodextrin (1:1M) can be used to enhance the solubility and dissolution rate of the drug. AC-DC-SOL (crosscarmellose sodium) as a super disintegrant shows faster release than both control and formulation by other superdisintegrants for quick release of the drug from the...
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Posted by admin on May 1, 2011 in |
Background: Parasitic helminth infection is one of the major risk factors underlying the high rates of anaemia and malnutrition in many third world countries due to the poor socio-economic and environmental conditions of the people and these play a very significant role in their transmission. Method: 2000 stool specimens collected between May and October 2008 at the Komfo Anokye Teaching Hospital in Ghana were screened using the Kato-Katz and formol-ether concentration methods for the presence of intestinal helminthes. Prior to sample collection, histories of any antihelmentic drug usage in the last three months preceding this study were collected. Hookworm positive stool specimens were further cultured by the modified Harada-Mori test-tube technique for the identification of the hookworm filariform larvae. Results: Hookworm (Necator americanus) was the most prevalent helminth parasite (2.9%) found in the study. Other parasitic helminthes detected were Dicrocoelium dendriticum (2.1%), Strongyloides stercoralis (2.1%), Schistosoma mansoni (1.8 %), Hymenolepis nana, (1.4%) Taenia species (0.6%) and Trichuris trichuria (0.1%). S. mansoni infection was however high among patients aged between...
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Posted by admin on May 1, 2011 in |
Hemangiomas are abnormal accumulation or growth of blood vessels in the internal organs or in the skin. Most hemangiomas occur at birth while others develop after birth. There are two types of hemangiomas the capillary hemangioma and the cavernous hemangioma. A capillary hemangioma is usually seen at the top layer, while the cavernous hemangioma is often found at the deeper layer. Some patients, however, may present with both types. The cavernous hemangioma, also known as cavernoma, occurs less commonly than the capillary hemangioma. It is a benign tumor of blood vessels that rapidly grows over a period of time and does not usually reduce in size. Most cavernous hemangiomas are usually soft to the touch. Hemangiomas are common vascular, childhood benign tumors with special predilection to head & neck region. Benign vascular tumors are fairly common with wide distribution through the body. They may be single or multiple. They may occur in combination, affecting a number of organs and producing well known syndromes but vascular tumors of the female...
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Posted by admin on May 1, 2011 in |
The present study was designed to investigate the antibacterial activity and free radical scavenging potential of methanloic extract of Pterocarpus santalinus (PSMExt). Significant MIC was observed against Bacillus subtilis (0.312 mg/ml). Free radical scavenging potential of PSMExt was evaluated by using total antioxidant activity (thiocyanate method), diphenyl-picryl-hydrazyl (DPPH) assay and nitric oxide (NO) assay. Results of the present study disclosed that PSMExt showed remarkable and concentration dependent free radical scavenging activity. Phytochemical analysis showed the presence of flavonoids, terpenoids and steroids. The present work indicated that the methanolic extract of Pterocarpus santalinus was capable of scavenging the free radicals and inhibited the tested bacteria, suggested the potential antibacterial and antioxidant...
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