Posted by admin on Sep 1, 2011 in |
Lead is a ubiquitous environmental and industrial pollutant that may have its toxic effects on the male. The present experimental animal study was designed to observe the changes in the testis due to excessive use of lead. Developmental effects were monitored in the male offspring of Swiss mice from Postnatal Day (PND) 1 till PND 21. Lead acetate reduced the number of pups per litter, percentage of live offspring, and pups weight. Testicular morphology was severely affected in mice exposed to Lead acetate. Therefore, exposure during gestation and lactation adversely affects the reproductive system of male mice. In present study lead toxicity induced histological alterations in the various components of the testis. It is observed in present investigation that lead acetate given in high dose (640mg/kg/days) caused decreased body weight as compared to control males during developing period of pups. The microscopic examination revealed that lead induced apparent damage and reduction in the number of seminiferous tubules and primordial germ cells. Oral exposure of lead acetate changed the arrangement...
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Posted by admin on Sep 1, 2011 in |
The aim of the present study is to evaluate the effect of methanol extract of aerial part of Momordica Cymbalaria Hook F on acute inflammation and it justifies the traditional use of this plant in the treatment of various types of pains and inflammation was evaluated in Albino rat. The aerial part of Momordica Cymbalaria Hook F extracted with methanol at an oral dose of 100 and 200 mg/kg body weight exhibited significant anti-inflammatory activity when compared with control. The anti-inflammatory activity of methanol extract of Momordica Cymbalaria Hook F. was evaluated by carrageenan-induced paw edema method in Albino rats. In carrageenan-induced paw edema model, Momordica Cymbalaria Hook F at doses of 100 and 200 mg/kg caused significant inhibition of paw edema by 53.11%( p<0.001) and 55.43 (p<0.001) respectively, 4 hours after carrageenan administration It is clearly evident from the study that an methanol extract of Momordica Cymbalaria Hook F exhibit significant anti-inflammatory effect in albino rats. Results of two doses are also comparable with standard drug (Indomethacin). All...
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Posted by admin on Sep 1, 2011 in |
An HPTLC method was developed for Qualitative and Quantitative Estimation of Gallic Acid and Ascorbic Acid in Polyherbal Tablets (Amalant and Sookshma Triphala Tablet) containing Embelica Officinalis, using precoated HPTLC silica gel 60 F254 as Stationary Phase and Mobile Phase for Gallic Acid is Toluene: Ethyl Acetate: Formic Acid (6:3:1v/v/v) and for Ascorbic Acid is Ethyl Acetate: Acetic Acid Glacial: Formic Acid: Water (6:1:1:2v/v/v/v). Detection and Quantification were performed densitometrically at λmax 254nm for Gallic Acid and Ascorbic Acid. The Standard Rf values of Gallic Acid and Ascorbic Acid are 0.34±0.01 and 0.60±0.01 respectively. The total peak areas of the Standards [Gallic Acid and Ascorbic Acid] and the corresponding peak areas of extracts were compared and the Gallic Acid content were estimated to be 3.01, 4.89% and 5.01% from Amla Powder, Amalant Tablet and Sookshma Triphala Tablet and the Ascorbic Acid were estimated to be 11.56%, 28.94%, 31.79% from Amla Powder, Amalant Tablet and Sookshma Triphala...
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Posted by admin on Sep 1, 2011 in |
Background: Infiltration and degranulation of mast cells has been noted to occur in renal diseases and are reported to play a key role in inflammation. Degranulation of mast cells releases various inflammatory mediators such as cytokines, endothelins, growth factors and proteolytic enzymes. Ketotifen has been reported as stabilizer of mast cells. Thus, the present study is designed to investigate the involvement of mast cells in diabetes induced nephropathy. Materials and methods: Male Wistar rats weighing 200-250 gm were given streptozotocin (50 mg/kg., i.p once) to induce diabetes mellitus and maintained hyperglycemic for eight weeks to produce nephropathy. Diabetes was assessed by serum glucose level and nephropathy was assessed by estimating serum creatinine level, blood urea nitrogen (BUN), total urinary proteins, oxidative stress (lipid peroxidation, reduced glutathione), renal collagen content and integrity of kidney was assessed histopathologically by Hematoxylin Eosin staining and for mast cells toluidine blue staining was done .After one week of streptozotocin, diabetic rats were treated with ketotifen (1 mg/kg., p.o) for 7 weeks. Standard mast cell...
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Posted by admin on Sep 1, 2011 in |
Poorly solubility in water of many newly developed high-potential drugs is an obstacle in formulation development. The aim of this study was to increase the solubility of Lamotrigine which is a poorly soluble drug and comes under BCS class-II by using solid dispersion technique. Lamotrigine, PEG 4000 and PVPK-30 solid dispersion was prepared by solvent evaporation method and the formulation was characterized using stability studies, Fourier transform infrared spectroscopy (FTIR) and physical parameters. After checking the preformulation studies and getting satisfactory results pellets were formulated and evaluation was done. Drug entrapment efficiency was more than 98 % which indicates that the pellets formed are good possessing in vitro release of 94.89 & 92.30 % for X1 & X2 batches respectively....
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