Posted by admin on May 1, 2011 in |
The present work is to evaluate the anxiolytic activity of a hydroalcoholic extract of Tephrosia purpuria (L) Pers (HAETP) in mice using the elevated plus-maze (EPM), elevated zero-maze (EZM), Y-maze and hole-board models. Furthermore, the anxiolytic effects of HAETP were compared to a known active anxiolytic drug diazepam. The extract, administered orally, in two different doses of HAETP 200 mg/kg and 400 mg/kg, was able to increase the time spent and the number of arm entries in the open arms of the elevated plus-maze and elevated zero-maze, as well as decrease the visits by mice in the Y-maze, also significantly increase nose poking, line crossing and rearing in hole-board. This effect was comparable to that of the diazepam (2.0 mg/kg i.p.). These results indicate that hydroalcoholic extract Tephrosia purpuria (L) Pers is an effective anxiolytic...
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Posted by admin on May 1, 2011 in |
Based on the scope given by traditional knowledge, present study was conducted. The aim of the present study was to evaluate the antibacterial activity of castor (Ricinus communis, Family: Euphorbiaceae) leaf extract using five bacteria; two Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) and three Gram-negative bacteria (Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa). The concentrated ethanolic extract of the crude drug of concentration 5gm/ml was tested for antibacterial activity by determination of zone of inhibition. Gentamycin is used as standard. It was found that the concentrated extract of the Ricinus communis leaves showed a better antibacterial activity in comparison with the...
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Posted by admin on May 1, 2011 in |
The proposed method is new, simple, sensitive, reproducible, economical, accurate and precise and can be successfully applied in estimation of Telmisartan (Telmi) from urine. This method can find applications in clinical studies and therapeutic drug monitoring. This method of colorimetric estimation of telmisartan from urine is based on the formation of yellow colored chromogen when it is reacted with alizarin in presence of thionyl chloride. The concentration of telmisartan over a range of 10-60 µg/ml was found to obey Beer’s law in the stated range. The yellow colored complex has absorption maxima at 427 nm with molar absorptivity and sandell’s sensitivity 2.2387 × 104 lit mol-1cm-1 and 0.0154 µg/cm2/0.001 absorbance units, respectively. The proposed method is highly sensitive, reproducible, specific, and the reagent was not found to react with the soluble matters of the body fluids. The results of analysis were validated as per ICH Q2B guidelines....
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Posted by admin on May 1, 2011 in |
To study the anti-inflammatory effect of different extract of leaves of Diplazium esculentum in rats. Anti-inflammatory activity was screened by measuring the reduction in carrageenan induced hind paw edema. The potency of various extracts of leaves was compared with each other and standard Ibuprofen (100mg/kg) for anti-inflammatory activity. The results indicated that all the extracts of Diplazium esculentum showed anti-inflammatory activity. Percentage inhibition of inflammation observed in chloroform extract group was more than other treated...
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Posted by admin on May 1, 2011 in |
Biodiesel is produced from vegetable oils (edible & non edibles) and animal fats. The methyl ester of vegetable oils, known as biodiesel are becoming increasingly popular because of their low environmental impact and potential as a green alternative fuel for diesel engine and they would not require significant modification of existing engine hardware. At present, biodiesel is commercially produced from the refined edible vegetable oils such as Schlichera oleosa seeds oil, etc. by alkaline-catalyzed esterification process. This process is not suitable for production of biodiesel from many unrefined non-edible vegetable oils because of their high free acid value. Hence, a two-step esterification method is developed to produce biodiesel from high FFA vegetable oils. The biodiesel production method consists of acid-catalyzed (H2SO4) pretreatment followed by an alkaline-catalyzed (KOH) transesterification. Methyl ester of Schlichera oliosa is derived through esterification and transesterification...
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