Posted by admin on Jun 1, 2011 in |
The ethanol extract of Hibiscus esculentus Linn roots inhibited the formation of oxygen derived free radicals were screened for their in vitro antioxidant activity. Stems leaves and root of selected plants were dried at 45°C and powdered for extraction. Extraction was performed with methanol. By employing DPPH (2, 2-diphenyl-1picrylhydrazyl radical) scavenging assays, it was shown that all the ethanol extracts of the samples collected show antioxidant activity. Though, as expected, their potency varied according to the different parts and species. In particular, leaves and stems of Hibiscus esculentus leaves displayed the highest activity. The extracts tested ranged from 0.176 mg/mL –2.45mg/mL. It is generally accepted that a diet rich in plants is associated with a reduced incidence of degenerative diseases, such as atherosclerosis and cancer. This study suggests that the Hibiscus esculentus plant could be pharmaceutically exploited for antioxidant...
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Posted by admin on Jun 1, 2011 in |
Flaxseed is being consumed as an ingredient in various food formulations as it plays a major role in the field of diet and disease research due to its potential health benefits associated with a- linolenic acid (57%) and its rich phytoestrogens or lignans. Hence, presently, it is in great demand by food industries and in nutraceutical applications. The present study was carried out using 80, 32-weeks old, Single Comb White Leghorn (SCWL) laying hens which were subjected to 4 dietary treatments, namely Control, 5% flaxseed endosperm-rich fraction (ERF), 10% ERF and 20% ERF. At the end of the 4th week, all groups were examined hematologically and histopathologically. There was a linear relationship between feed consumption and decrease in body weight. The decrease in the weight of the birds was directly proportional to the concentration of ERF in the diet. Packed cell volume (PCV) and red blood cell (RBC) counts had a negative significance (p<0.05) linear relationship with the ERF level. There was a decrease in PCV and RBC counts...
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Posted by admin on Jun 1, 2011 in |
Simple, fast and economic spectrophotometric methods were developed for determination of Tolterodine in bulk and pharmaceutical dosage forms using water as the solvent. The quantitative determination of the drug was carried out using the zero order derivative measured at 281.5 nm, first order derivative measured at 274 nm and area under curve was measured in wavelength range of 276-286 nm. Calibration graphs constructed were linear in the concentration range 30-180 μg.mL-1 with r² = 0.9998, r² = 0.9998 and r = 0.9997 for zero order, first order derivative and area under curve method respectively. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations....
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Posted by admin on Jun 1, 2011 in |
Mallotus tetracoccus (Roxb.) Kurz. is found in Western Ghats of India. Mallotus tetracoccus is one of the medicinally important plants belonging to the family Euphorbiaceae, commonly known as “vatta kanni” in Tamil. In the present study the ethanolic extract of Mallotus tetracoccus has been subjected to GC-MS analysis. The major chemical constituents are Bis (2-ethyl hexyl) phthalate (46.78%), 3-methyl-2-(2-oxypropyl) furan (13.31%), E-8-methyl-9-tetradecen-1-ol acetate (6.63%), Octadecanoic acid, 2-oxo (4.46%) and Longiborneol (2.39%). Thus the extract of Mallotus tetracoccus was characterized by substantial levels of diesters (50%), alcohols (15%), alkanes (3%), sesquiterpenes (5%), terpenoids (13%), fattyacid (5%) and sugars (2.6%). The presence of some of these constituents in the plant extract provides the scientific evidences for the antipyretic, anti-inflammatory and hepatoprotective properties of the...
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Posted by admin on Jun 1, 2011 in |
The methanol extract of the stem bark of Anogeissus leiocarpus was evaluated in vivo at 2.5mg/kg for antioxidant, hepatoprotective and ameliorative effect on hepatocellular injury following pre-treatment or post-treatment with carbon tetrachloride (CCl4). Levels of the lipid peroxidation product, malondialdehyde (MDA) or thiobarbituric reactive substances (TBARS) were taken as a measure of oxidative stress, while levels of biochemical such as aspartate aminotransferase, alanine aminotransferase and bilirubin (total and conjugated) were taken as biomarkers of liver damage. Irrespective of whether the animals were pre- or post- treated with Anogeissus leiocarpus, there was no statistical difference between the levels of MDA and markers of liver damage in the groups on A. Leiocarpus + CCL4 group and Vitamin E + CCl4, although both were significantly (P<0.05) lower than in the group on CCL4 only. However, malondialdehyde (MDA) levels in the heart, and to some extent, in the kidney, were hardly influenced by the treatments. These results indicate that methanolic extract of the stem bark of Anogeissus leiocarpus possess antioxidant, hepatoprotective and ameliorative...
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