Posted by admin on Apr 1, 2011 in |
Hepatitis is major health problem in human being due to various chemical including therapeutic agent and environmental toxin and this can leads to illness like jaundice, which sometime may lead to even death. Ipomoea digitata Linn. is used in ayurvedic formulation for various disease conditions and commonly known as “Vidarikanda”. The present study deals with hepatoprotective activity hydroethanolic extract of tuberous root of Ipomoea digitata Linn. against CCl4 (i.p) induced liver damaged in female Wister rat. The drug was extracted and preliminary phytochemical screening of extract was done then extract was subjected to toxicity study. The hydroethanolic extract of tuberous root of Ipomoea digitata Linn. was administered orally at the dose of 250mg/kg and 500mg/kg .These shows significant protective effect on liver evidenced by lowering serum level of ALT, AST, ALKP, TB, DB, and Serum Triglyceride and also by histopathological study. All result obtain result are compared with standard (Silymarin) and control group. Thus it concludes that hydroethanolic extract of Ipomoea digitata Linn. shows significant hepatoprotective activity prevents chemically...
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Posted by admin on Apr 1, 2011 in |
Adrenal myelolipomas are rare benign endocrinologically inactive tumor composed of mature adipose tissue and hematopoietic cells in varying proportions. Most lesions are small, unilateral and asymptomatic, discovered incidentally at autopsy or on imaging studies performed for other reasons. Its characteristic appearance on sonography and computed tomography enables preoperative diagnosis with a high degree of safety and accuracy. The association of adrenal myelolipoma with cholelithiasis is not well documented in the literature. It could be an incidental association or there may be a common underlying pathologic basis. Here we report a rare case of adrenal myelolipoma in a 30-year old woman. Our case was unusual because of large size, symptomatic presentation and associated gall...
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Posted by admin on Apr 1, 2011 in |
Aerial parts of Ruellia prostrata were subjected to extraction and further fractionation to obtain antioxidant rich fraction. Different concentrations of methanolic extract and its n-butanolic fraction were subjected to antioxidant assay by DPPH method, Nitric oxide scavenging activity and reducing power assay. The fractions showed dose dependent free radical scavenging property in all the models. IC50 values for methanolic extract and its n-butanolic fraction were found to be 137.89±5.74 and 42.25±3.17 respectively in comparison to L-Ascorbic acid and Rutin as standard with IC50 values of 6.537±0.235 and 5.437±0.206 respectively, in DPPH model. In nitric oxide scavenging activity the IC50 values were found to be 152.22±6.37 and 67.70±2.29, 21.06±0.953 and 29.93±0.324 for methanolic extract and its n-butanolic fraction, L-Ascorbic acid and Rutin respectively. The fractions showed good reducing power with increasing concentration. However, the n-butanolic fraction showed a good reducing power and better free radical scavenging activity as compared to methanolic extract thus its antioxidant potential is comparable to standards. The phytochemical screenings confirm the presence of triterpenoids glycosides and...
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Posted by admin on Apr 1, 2011 in |
Sustained-release drug delivery system containing Ranolazine (an anti-anginal drug) with different ratios of pH dependent polymer, Eudragit L100-55 was designed by wet granulation method. The physicochemical compatibility of the drug and polymers were studied by FTIR spectrophotometer and found to be compatible. The in vitro release of Ranolazine SR tablets was studied in 900 ml of 0.1N HCl as dissolution medium using a USP dissolution paddle assembly at 50 rpm and 37±0.5°C. The promising formulation with concentration of Eudragit L100-55 polymer 12.5% showed better release of 99.78±0.99% after 24 hours. It showed Zero-order release with linearity (r=0.9447 to 0.9895). The similarity factor (f2 values) was used for the comparison of in vitro release study of the best formulation of SR tablets and marketed ER product of Ranolazine. The f2 values found to be 77.29. Based on the similarity factor (f2 values), the F4 formulation of SR tablets can be considered as optimized formulation in comparison with marketed ER product’s drug release profile. To study the mechanism of drug release...
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Posted by admin on Apr 1, 2011 in |
Chronopharmacokinetic studies have been reported for many drugs in an attempt to explain chronopharmacological phenomena and demonstrate that the time of administration is a possible factor of variation in the pharmacokinetics of a drug. The present study aimed at preparing a novel time dependent pulsed release system containing ‘pellets in-capsule’ device plugged by biodegradable polymers for the programmed release of theophylline for the treatment of nocturnal asthma. The pellets of theophylline were prepared using direct compression method containing a superdisintegrant. Physical characterization of the plug and pellets used was under taken using a range of experimental technique. Karaya gum, Xanthum gum and cross-povidone XL 10 were used as polymers for making plug which were fitted on to the capsule. Factors studied in design were percentage of drug entrapment, swelling index and the effect of plug position on In-vitro drug release. Dissolution studies of pulsatile capsule device in media with different pH (1.2, 6.8 and 7.4) showed that drug release in colon could be modulated by optimizing the concentration of...
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