Posted by admin on Aug 1, 2011 in |
The present study was undertaken to formulate directly compressible tablets to investigate the effect of different disintegrating agents such as maize starch and avicel PH101 on disintegration time, in vitro drug dissolution and their release properties. Tablets of paracetamol and the combination of paracetamol and diclofenac using maize starch and avicel PH 101 were prepared separately by direct compression method. The in vitro release of these formulations were studied at distilled water for one hour using the USP paddle method as specified in united states pharmacopeias for immediate release preparation. Significant differences were found among the drug release profile from different tablet formulations using different disintegrants. Formula No. 3 containing the combination of paracetamol and diclofenac using maize starch showed the lowest hardness and disintegrating time i.e. 3.99 Kg/cm2 and 7.08 minutes respectively, and the highest drug release i.e. 75.50% compared to other formulations. The influence of different disintegrants was evaluated by measuring the disintegration time and hardness of the tablets. The effect of starch & avicel on the...
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Posted by admin on Aug 1, 2011 in |
This study evaluated the in vitro antioxidant and cytotoxic potential of methanolic extract of the root of Calotropis procera (R. BR.). The Antioxidant activity of the extract was investigated by the In-vitro Anti-Oxidant activity (DDPH Scavenging activity) assays. The IC50 of the Calotropis procera studied by the above mention method was found below 100 μg/ml which indicates the potent antioxidant activity of the plant. The extract of the root of Calotropis procera also demonstrated a strong cytotoxic activity against brine shrimp nauplii with an LC50 value of 2.931...
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Posted by admin on Aug 1, 2011 in |
The present work attempted to identify and standardize the different phytochemical by modern analytical techniques and to summarize the UV, TLC, FTIR characters of the plants; Eugenia caryophyllus (clove), Acorus Calamus (vekhand), Myristica fragrans (Nutmeg) and Citrus aurantium(Orange peel) which ultimately results in compilation of analytical data for these crude drugs which are very much used in herbal cosmetics. The methanolic extracts of Clove, Acorus, Nutmeg, Orange peel were prepared by ultrasonic bath extraction method and labeled as DSC, DSA, DSN and DSO respectively for further studies. Preliminary pytochemical screening of extracts were also performed. Asarones were detected in Acorus extract by subjecting the TLC to UV light and observing blue fluorescence. Volatile oil was isolated from clove buds by using Clevenger’s apparatus which was subjected for the FTIR analysis, which indicates the peak for presence of phenol compound. For nutmeg and orange peel samples the presence of myristicine, elemicine in nutmeg extract was confirmed by Rf...
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Posted by admin on Aug 1, 2011 in |
Ocimum sanctum (L.) is popularly used as herbal remedy for various ailments. But the scientific basis for its medicinal use especially in pain and inflammation remains unknown. Therefore, the present study was aimed to investigate the analgesic and anti-inflammatory effects of the leaves of Ocimum sanctum in laboratory animals. The ethanol extract of the leaves of O. sanctum was used to investigate the acute effect on analgesia by Hot-plate test in mice and on inflammation in rats using carrageenan-induced rat paw edema model. The extract showed a significant (p<0.05) dose dependent increase in reaction time in mice in the hot-plate test at the doses of 250 and 500 mg/kg body weight. The extract also exhibited promising anti-inflammatory effect as demonstrated by statistically significant (p<0.05) inhibition of paw volume by 43.33% at the dose of 500 mg/kg body weight at the fourth hour of study. This study suggests that the ethanol extract of Ocimum sanctum have both analgesic and anti-inflammatory activity in a dose dependent manner which supported its use...
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Posted by admin on Aug 1, 2011 in |
Selected physicochemical parameters, total phenolics, flavonoids and free radical scavenging activity of honey samples from the northern savannah region and southern rainforest ecosystems of Nigeria were investigated. Moisture and ash content of most samples were within acceptable limits. Total phenolic content ranged from 23.92 to 82.34mgGAE/100g for both ecosystems. Flavonoids varied between 2.52 – 27.21mgQE/100g for honey samples from the northern savannah zone and 9.17 – 22.38mgQE/100g for honey samples from the southern rainforest ecosystem. The samples exhibited good antioxidant activity using the DPPH assay and poor metal chelating activity. A linear positive relationship existed between antioxidant activity and total phenolics (R2= 0.85)/flavonoids (R2 = 0.78). The analyzed honey samples possess valuable antioxidants for culinary and medicinal...
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