Posted by admin on Apr 1, 2011 in |
The objective of the present study was to develop venlafaxine hydrochloride orodispersible tablet by using conventional techniques which are simple and cost effective such as use of superdisintegrant technology. In this, sodium starch glycollate and Crosscarmellose sodium were used in the rapid disintegration of the tablets. In this various trials were conducted for the selection of optimum concentration of superdisintegrant. The optimized formula aids in the stabilization of final product. The blend and compressed tablets were evaluated for physical characteristics like bulk density, tapped density, angle of repose, hardness, friability, disintegration time, wetting time, water absorption ratio, In-vitro dispersion time and chemical characteristics like In-vitro dissolution, content uniformity and assay. The stability study was conducted for the optimized batch. This design of dosage form will open a new era for rapid disintegration...
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Posted by admin on Apr 1, 2011 in |
Aerial parts of Ruellia prostrata were subjected to extraction and further fractionation to obtain antioxidant rich fraction. Different concentrations of methanolic extract and its n-butanolic fraction were subjected to antioxidant assay by DPPH method, Nitric oxide scavenging activity and reducing power assay. The fractions showed dose dependent free radical scavenging property in all the models. IC50 values for methanolic extract and its n-butanolic fraction were found to be 137.89±5.74 and 42.25±3.17 respectively in comparison to L-Ascorbic acid and Rutin as standard with IC50 values of 6.537±0.235 and 5.437±0.206 respectively, in DPPH model. In nitric oxide scavenging activity the IC50 values were found to be 152.22±6.37 and 67.70±2.29, 21.06±0.953 and 29.93±0.324 for methanolic extract and its n-butanolic fraction, L-Ascorbic acid and Rutin respectively. The fractions showed good reducing power with increasing concentration. However, the n-butanolic fraction showed a good reducing power and better free radical scavenging activity as compared to methanolic extract thus its antioxidant potential is comparable to standards. The phytochemical screenings confirm the presence of triterpenoids glycosides and...
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Posted by admin on Apr 1, 2011 in |
Our aim was to determine the effect of rutin, a flavonol glycoside on ethanol induced hepatic lipid accumulation in experimental rats. Male albino Wistar rats were randomized into four groups. Groups 1 and 2 received isocaloric glucose. Hepatic injury was induced in groups 3 and 4 by administering 20% ethanol via intragastric intubation for 60days. In addition, groups 2 and 4 were given rutin (100 mg/kg) daily for the last 30 days of the experiment. Ethanol alone administered rats showed a significant increase in the levels of total cholesterol (TC), triglycerides (TG), free fatty acids (FFA), phospholipids (PL), low density lipoproteins (LDL) and very low density lipoproteins (VLDL) with a concomitant decrease in the levels of high density lipoproteins (HDL). Haematoxylin and eosin staining of the liver of ethanol alone fed rats showed inflammatory cell infiltrates and fatty changes Supplementation with rutin reversed the ethanol induced alterations in lipid profile and also restored the liver histology which appeared similar to the control rats. Together the results obtained clearly reveal...
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Posted by admin on Apr 1, 2011 in |
This study deals with the synthesis and evaluation of antimicrobial activity of some novel Thiophene acrylate compounds. Totally fourteen compounds have been synthesized with different heterocyclic moieties on the Thiophene acrylate in order to study their influence on the antimicrobial activity. These compounds demonstrated potent to weak antibacterial activity against Gram-positive...
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Posted by admin on Apr 1, 2011 in |
The ethanolic extract of whole plant of Coriandrum sativum Linn., family: Umbelliferae, was assessed for its possible analgesic, antidiarrhoeal, antimicrobial and cytotoxic activity. Preliminary phytochemical screening of the ethanolic extract revealed the presence of alkaloids, tannins, glycosides, and gums. In acetic acid induced writhing in mice, the ethanolic extract (250 and 500 mg/kg) exhibited significant (p<0.001 & p<0.001) inhibition of writhing reflex 62.12% and 72.73% respectively compared to standard diclofenac sodium. The extract showed a significant (P<0.01 and P<0.001) antidiarrhoeal activity against castor oil induce diarrhea in mice in which it decreased the frequency of defecation and increased the mean latent period at the dose of 250 mg/kg and 500 mg/kg body weight. The ethanolic extract showed moderate antibacterial activity against both gram-positive and gram-negative bacteria. In the brine shrimp lethality test, the extract showed cytotoxicity significantly with LC50 40 μg/ml which was comparable to that of standard drug Chloramphenicol (LC50 20 μg/ml). All the results tend to justify the traditional uses of the plant and require further investigation...
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