Posted by admin on Aug 1, 2011 in |
The present study was carried out to evaluate CNS activity of ethanolic extract of roots of Anacyclus pyrethrum that includes general behavior studies, sedative, muscle relaxant, anxiolytic, nootropic activity and antidepressant studies in rats. The results reveal potential neuropharmacological activity of Anacyclus pyrethrum as nootropic and also having antidepressant property. Further neurochemical investigation can unravel the mechanism of action of plant drug with respect to nootropic and antidepressant activity. Preliminary investigation showed that ethanolic extract of Anacyclus pyrethrum has significant neuropharmacological...
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Posted by admin on Aug 1, 2011 in |
The present study was designed to investigate antibacterial, insecticidal and in vivo cytotoxic activities of the methanol: ethylacetate (1:9) extract of leaves, barks and roots of Salix tetrasperma. Antibacterial test were done against five Gram-positive and four Gram-negative bacteria. Bark extract was active against all tested microbial species and the highest activity was shown against Escherichia coli with a zone of inhibition 12 ± 0.02 mm. The leaves extract was active against all the Gram positive bacterial strain whereas inactive against all the Gram negative bacterial strain except Shegella flexneri while root extract showed insignificant activity. In insecticidal study, the root and leaves extract of Salix tetrasperma showed moderate activity with 26% and 20% mortality rate of Tribolium castaneum at a dose of 50mg/ml in 48 hours, respectively and bark extract had no activity. In respect of in vivo cytotoxicity, Root and bark extract showed moderate cell growth inhibition, whereas leaves extract had no activity at...
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Posted by admin on Aug 1, 2011 in |
Ixora pavetta Vahl. is a small tree, traditionally used for the treatment of diarrhoea, dysentery, urinary disorders, leucorrhoea, veneral diseases and sedative. The flowers of the plant were extracted with ethanol by cold percolation method. The presence of the compounds in the extract was analyzed by GC-MS technique. The parameters of mass spectral analysis viz. retention time and characteristics of peak using NIST library were considered for the detection of compounds, The compounds viz. 3-Butyn-2-ol, 3-Butyn-1-ol, Amyl nitrite, 2Octyn-1-ol, 1, 9-Decadiyne and Butyl glyoxylate were identified from the study. With reference to the phytochemical and ethanobotanical databases, the Pharmacological activity of the compounds which identified were found out and compared with its traditional uses. Sedative property is one of the traditional uses of Ixora pavetta was found to be due to the presence of Amyl nitrite in the extract....
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Posted by admin on Aug 1, 2011 in |
Andrographis paniculata Nees. is an important medicinal plant in India which is used in traditional medicine. Although, its antibacterial property has been shown by some researchers, there are very few studies showing its antioxidant activity and there are no reports of its antifungal activity against dermatophytes. So, in this study we evaluate the antibacterial, antifungal and antioxidant activities of A. paniculata leaves in different solvent extracts. A. paniculata leaves were extracted with chloroform, hexane, methanol, ethanol and water separately and phenol and flavonoid contents were estimated in these extracts. The antibacterial and antifungal activity studies were carried out by using disc diffusion method and mycelial dry weight method respectively. Ferrous reducing antioxidant power assay, 1, 1-diphenyl-2-picryl hydrazyl (DPPH) scavenging activity, lipid peroxidation inhibitory activity and superoxide scavenging activity were used for in vitro antioxidant activity studies. A. panicualta ethanol leaf extract showed the highest phenol and flavonoid contents of 64.82 mg/g and 0.87 mg/g respectively. The highest antibacterial activity was recorded in the ethanol extract with Minimum Inhibitory Concentration...
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Posted by admin on Aug 1, 2011 in |
The aim of this study was to prepare and evaluate poly(ε-caprolactone) (PCL) microspheres containing acetazolamide. Microspheres were prepared by solvent evaporation method. The influence of formulation factors (polymer: drug ratio, aqueous: oil phase ratio, concentration of aqueous phase, stirring speed and stirring time) on morphology, particle size, encapsulation and recovery efficiency were investigated. The microspheres were spherical with a mean diameter of 99.09±1.71μm, the encapsulation efficiency was 75.28±0.97% (w/w) and the recovery efficiency was 88.23±1.06% (w/w). In vitro release studies revealed a controlled release of acetazolamide from PCL microspheres suitable for peroral administration. In conclusion, PCL microspheres containing acetazolamide were successfully prepared by using solvent evaporation method with the selection of appropriate experimental...
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