Posted by admin on Apr 1, 2011 in |
A series of new Thienyl acrylate compounds were synthesized via Baylis-Hillman reaction and tested to demonstrate in vitro antimicrobial activity. Some of these compounds exhibited a very good activity against Gram positive strains. The structure of these newly synthesized compounds were conformed by 1H NMR, IR, Mass and Elemental analysis, some of them were also confirmed by 13C...
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Posted by admin on Apr 1, 2011 in |
The various parts of Balanites aegyptiaca (L.) Del (Balanitaceae) is used in Ayurvedic and other folk medicine for the treatment of various ailments such as syphilis, jaundice, liver and spleen problem, epilepsy and yellow fever. This study was designed to evaluate the hepatoprotective and antioxidant effect of ethanol extract of aerial part of Balanites aegyptiaca on CCl4 induced hepatotoxicity in rats. Activities of liver marker enzymes, SGOT, SGPT and ALP, total protein, albumin, globulin, total, conjugated and unconjugated bilirubins at an oral dose of ethanol extract of Balanites aegyptiaca (100 and 200mg/kg) showed a significant hepatoprotective effect. Regarding antioxidant activity, ethanol extract of Balanites aegyptiaca exhibited a significant effect showing increasing levels of SOD, CAT, GPX and GRD by reducing malondialdehyde (MDA) levels....
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Posted by admin on Apr 1, 2011 in |
The electrochemical reduction of anti- parasitic drug “Tinidazole” has been carried out in aqueous solution in the pH range 2.3 to 11.3 by Direct current (DC) polarography. Tinidazole exhibits one or two reduction peaks depending on pH. In basic medium one reduction peak was observed. Along with different pH, studies of drug have been carried out with different concentrations of drug and at different temperatures. The reduction of tinidazole was found to be irreversible so kinetic parameters (Ko fh, αn) are evaluated using Meites-Israel and Gaur-Bhargava’s methods. Thermodynamic parameters such as ∆Hp≠, ∆Hv≠, ∆G≠ and ∆S≠ are also evaluated....
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Posted by admin on Apr 1, 2011 in |
Nanodrop spectrophotometric method was developed and validated for the estimation of Ranolazine in bulk. Ranolazine exhibited λmax at 272nm in water and obeyed linearity in the concentration range of 12.5-2000 ppm. The proposed method has been applied successfully for the analysis of Ranolazine in bulk with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of Ranolazine in...
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Posted by admin on Apr 1, 2011 in |
The in vitro activity of the petroleum ether extract of fruit part of Phyllanthus acidus was tested for cytotoxic antibacterial and antioxidant activities as well as for phytochemical screening. The plant was collected from Savar, Dhaka. Phytochemical screening of petroleum extract of phyllanthus acidus revealed the presence of carbohydrate, glycoside and steroid. The extract exhibited antibacterial activity was determined by the disc diffusion method against thirteen pathogenic bacteria and the cytotoxic activity was performed by brine shrimp lethality bio-assay method. The higher concentrations showed antimicrobial activity against a number of bacteria including Salmonella typhi, Staphylococcus aureus, Bacillus cereus, Escherichia coli, Bacillus megaterium. In brine shrimp lethality bio-assay, the LC50 value was 3.12. The phenolics contents was 159.601 mg/g GAE and the amount of flavonoid was 24.183 mg/g of quercetin equivalent. The DPPH radical scavenging activity of Phyllanthus acidus was found to slight increase with increasing concentration of the extract and IC50 value showed 1192.263 µg mL−1 for plant extract compared to 13.37 µg mL−1 which was the IC50 value...
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