Posted by admin on Jun 1, 2011 in |
A simple, rapid, accurate, precise, specific and economical spectrophotometric method for simultaneous estimation of Gliclazide (GLC) and Metformin hydrochloride (MET) in combined tablet dosage form has been developed. It employs formation and solving of simultaneous equation using two wavelengths 227.0 nm and 237.5 nm. This method obeys Beer’s law in the employed concentration ranges of 5-25 μg/ml and 2.5-12.5 μg/ml for Gliclazide and Metformin hydrochloride, respectively. Results of analysis were validated statistically and by recovery...
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Posted by admin on Jun 1, 2011 in |
An Ulcer is a sore which means an open painful wound in mucous membranes or mucosal linings of the body. Gastro intestinal ulcers frequently occur in the stomach and duodenum where acid and pepsin activity is greatest. Peptic ulcer disease can be prevented by strengthening the cytoprotection, the defensive mechanism of gastric mucosa, rather than attenuating factor of aggression causing ulceration. Michelia champaca Linn., a well known member of Magnoliaceae is known for its fragrant flowers and various pharmacological actions. Anti-ulcerogenic activity of Michelia champaca Linn. flower and leaves are evaluated against aspirin induced gastric ulcers in pylorus ligated rats. The anti-ulcer potential is determined by using gastric juice volume, total acidity, pH and ulcer index. Both aqueous and alcoholic extracts of Michelia champaca Linn. flower and leaves are evaluated for their anti ulcer potential at about a dose of 300mg/kg b.wt, and are compared with the standard drug Cimetidine (50mg/kg b.wt). All the four extracts are said to possess significant anti ulcer potential by decrease in gastric juice...
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Posted by admin on Jun 1, 2011 in |
The Methanolic extract of leaves (LE) and Methanolic extract of flowers (FE) of Nerium indicum (Arali) was analysed for Antioxidant activity (AOA) in terms of DPPH free radicals, Total Phenolic Content (TPC) was measured in terms of Gallic acid equivalent and Flavonoid content was analysed in terms of Quercetin equivalent. The antioxidant activities of (LE & FE) were found to be 72.8% and 67 %. TPC of study extracts (LE & FE) were found to be 227 mg/100g and 449 mg/100g. The Total Flavonoid content of (LE & FE) were found to be 125 mg/100g and 199 mg/100g respectively. Superoxide anion radical scavenging activity of flowers was 66 % compared to leaves 25 %. Similarly Lipid Peroxidation showed higher activity in flowers than leaves. Enzymatic antioxidant activity such as Superoxide Dismutase, Glutathione peroxidase and Catalase of Nerium indicum flowers were around 10% to 30% higher than that of leaves. The results clearly indicate that the methanol extracts of Nerium indicum flowers have more potent antioxidant activity than...
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Posted by admin on Jun 1, 2011 in |
The present study was designed to determine the antidiabetic activity of the methanol: ethyl acetate (1:9) extract of flower buds of Peltophorum pterocarpum on alloxen and glucose indueced diabetic mouse model. The extract was given intraperitonially at a dose of 200 mg/kg body weight and the hypoglycemic effects compared with metformin, a standard drug. The extract reduced blood glucose level in alloxan-induced diabetic mice by 60.40%, and 65.48% reduced by metformin at 12 hours in 24 hours treatment period. Preliminary phytochemical screening of the extract revealed the presence of different types of compounds including flavonoids and steroids. Our results suggest that Peltophorum pterocarpum has potential antidiabetic activity and may provide new molecules for the treatment of...
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Posted by admin on Jun 1, 2011 in |
Cyclocondensation of α-bromo ketones with thiourea afforded 4-substituted 1, 3-thiazole-2-amines. These compounds on further treatment with α-bromo ketones afforded 3, 6-disubstituted imidazo[2, 1-b][1, 3]thiazole (1a-1j). All the synthesized compounds were confirmed for their structure by FTIR, 1H NMR and GSMS spectra and tested in vitro for their anti-microbial activity by cup plate method against Gram-positive bacterial strains (Bacillus subtillis, Staphylococcus aureus) Gram-negative bacterial strains (Pseudomonas aerugenosa, Kleibsella pneumonia) and fungal strains (Aspergillus niger, Candida albicans). The analogues 1b, 1h and 1i showed promising antimicrobial activity against gram-negative Kleibsella pneumonia; where as analogues 1b, 1e, 1g and 1h showed promising antifungal activity against Candida...
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