Posted by admin on Apr 1, 2011 in |
Cressa cretica is halophytic plant belongs to family Convolvulaceae, growing extensively all over India. The entire plant is medicinally important and used extensively in traditional system of medicine. The present work attempted to summarize the macroscopic characters of the plant Cressa cretica. The microscopic characters, physical constant values, extractive values, fluorescent analysis of the plant were carried out. Preliminary phytochemical screenings of extracts were also performed. The present investigation contributes to establish the Pharmacognostic profile of the medicinally effective...
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Posted by admin on Apr 1, 2011 in |
In the present study Rizatriptan benzoate, which is the bitter drug requires taste, masking. β- Cyclodextrin is used in taste masking, which improves the patient compliance and also increases the rate of dissolution. Solid dispersion of drug and β- Cyclodextrin were prepared which was optimised in 1: 8 ratios, which gave satisfactory results for taste masking. This was then characterised using Differential scanning colorimetry (DSC), X-ray diffraction (XRD) and Infra Red (IR). The prepared solid dispersion was then formulated into tablets using varying concentrations (0-30%) of sublimating agents. The sublimating agents used were camphor and ammonium bicarbonate. The formulated powder blend was evaluated for angle of repose, bulk density, tapped density, Carr’s index. These powder properties showed good flowability. Tablets were formulated by direct compression. The sublimation process produced pores into the tablets, which allowed easy penetration of dissolution media followed by rapid release of the drug, which is the major aim of melt-in-mouth tablet dosage form. The tablets were evaluated for hardness, friability, disintegration time (in vitro, in...
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Posted by admin on Apr 1, 2011 in |
The present study was carried out to investigate the effect of oral feeding of A. indica leaf (powder, aqueous and 80% ethanol extract) in STZ induced type 2 diabetic rats. Diabetes was induced by single intraperitoneal injection of STZ to 48hrs old pups and experiments were carried out three months later. For chronic experiment type 2 rats were divided into 5 groups: 1) Water control, 2) Glibenclamide (5gms/kg b.w.) treated, 3) A. indica powder [mixed with rat feed (1.25 g/kg b.w.)], 4) Aqueous extract and 5) 80% ethanol extract treated. The test drugs were used at a dose of 1.25 g/kg b.w. for 28 consecutive days. Body weight was checked every week. Blood was collected by cutting the tail tip at the beginning and on the days 7, 14, 21 and by decapitation on the 28th day. Results of the experiment showed that A. indica leaves exerted a gradual reduction in serum glucose level of type 2 diabetic rats. A significant reduction in serum glucose level was noticed on...
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Posted by admin on Apr 1, 2011 in |
2-amino-4-chlorophenol (ACP) is a synthetic precursor of the skeletal muscle relaxant; chlorzoxazone. A rapid simple colorimetric method was proposed for the determination of 2-amino-4-chlorophenol as a potential impurity in chlorzoxazone bulk powder via its reaction with 4-aminoantipyrine in presence of alkaline oxidizing agent (K3[Fe(CN)6] / NH3) and measuring the produced red color at 520 nm. Different experimental parameters affecting the formation of the reaction product were studied. The study included the effect of volumes of the used reagents as well as the effect of time on the formation and stability of the reaction product. The formation constant (Kf) of the reaction product was found to be 1.2 x 104 indicating a very stable reaction product. Moreover, the Gibbs free energy change of the reaction (ΔG) was found to be -2.3 x 104 K.J/mole pointing out to the spontaneous nature of the reaction. The method was successfully applied for the trace analysis of the studied compound in spiked chlorzoxazone powder. The calibration graph was linear over the range of 1-20 µg/ml with average recovery of 100.58±0.89, detection limit of...
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Posted by admin on Apr 1, 2011 in |
The global demand of concrete is increasing every year and generally is considered as most consumed material on earth. But concrete is vulnerable to deterioration, corrosion, and cracks, and the consequent damage and loss of strength requires immensely expensive remediation and repair. One such mechanism that receives increasing attention in recent years is the ability for self-repair. So a novel and inexpensive method is available for overcoming the mentioned problem. The microbial concrete makes use of calcite precipitation by bacteria. A specific group of alkali-resistant spore-forming bacteria related to the genus Bacillus was selected for this purpose, the phenomenon is called microbiologically induced calcite precipitation (MICP). Bacillus Pasteruii, a common soil bacterium, can induce the precipitation of calcite. Due to its inherent ability to precipitate calcite continuously, bacterial concrete can be called as a “Smart Bio Material” for repairing...
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