Posted by admin on Jul 1, 2011 in |
The present study carried out to investigate the antihyperglycemic, oral glucose tolerance test (OGTT) and antihyperlipidemic (Total cholesterol and triglycerides) effects of the different fractions (Petroleum ether, ethyl acetate and chloroform) of ethanolic extract of Stevia rebaudiana leaves. The different fractions of the extract were administered orally as a single dose of 150 mg/kg body weight to alloxan induced hyperglycemic rats and found to reduce blood glucose level significantly (p<0.05). The different fractions resulted in the significant reduction of lipid content which was increased in hyperglycemic rats. The plant fractions also improve the glucose tolerance in the glucose induced rats. The effects of plant fractions were compared with standard drug metformin. The phytochemical screening tests indicated that the different constituents such as saponins, tannins, triterpines, alkaloids, flavonoids and glycosides etc. were present in the plant which has antidiabetic and hypolipidemic properties. Thus, this investigation paves the way for plant based antihyperglycemic and antihyperlipidemic treatment and indicates that various fractions (Petroleum ether, ethyl acetate and chloroform) of the ethanolic extract...
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Posted by admin on Jun 1, 2011 in |
Lagenaria siceraria is traditionally being used in many countries in the treatment of various diseases including diabetes. The aim of the present study was to evaluate the safety of the methanol extract of L. siceraria aerial parts (MELS) through acute and subchronic toxicity study in mice. For acute toxicity study 500-2000 mg/kg MELS were administered orally and obvious toxic symptoms and mortality was studied upto 72 h. In subchronic study, effect of multiple weekly dosing of 400 mg/kg (one-fifth of the maximum tolerated dose) of MELS was investigated in mice for six weeks and the evaluation was done by the studies of hematological parameters, biochemical estimations of hepatorenal parameters, antioxidant status, and histological observations of the tissue. The extract was found to be well tolerated upto 2g/kg in acute toxicity study. In subchronic toxicity study it showed no significant alteration on any of the parameters, however an improvement in the lipid profile was observed in the treated group of animals. Hence the results suggest that methanol extract of L.siceraria...
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Posted by admin on Jun 1, 2011 in |
The present study was aimed to evaluate the antioxidant activity of A.sessilis plant extracts in different solvents. The antioxidant activity was studied by phosphomolybdate method and DPPH method. In phosphomolybdate method the highest activity was shown by methanolic extract (12.044 mM of ascorbic acid eqvt/gm of sample). The highest radical scavenging activity by DPPH method was found in methanol extracts (IC 50 587.093µg/ml). Ferrous chelating activity, superoxide radical scavenging activity, nitric oxide radical scavenging activity was found high in acetone, acetone and methanol extracts respectively. Total Flavonoids and crude phenolics were found to be 0.370 mg/gm dry wt. and 1.529 mg/gm dry wt. respectively. The antioxidant activity increases with increase in the concentration. This study indicates that A.sessilis is a potential source of natural antioxidant....
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Posted by admin on Jun 1, 2011 in |
Some N-{4-[(6-chloro-4-oxo-4H-chromen-3-ylmethylene) imino] phenyl}-2-(substituted phenoxy) acetamide derivatives (3) were synthesized by reacting N-{4-[(6-chloro-4-oxo-4H-chromen-3-ylmethylene) imino] phenyl}-2-chloroacetamide (2) with some substituted phenol in dry acetone in the presence of K2CO3 and catalytic amount of KI. The chemical structures of the compounds were elucidated by IR, 1H-NMR and elemental analysis. Their antibacterial activity against gram positive bacterial strains (S. aureus and B. subtilis) and gram negative bacterial strains (E. coli and P. aeruginosa) were investigated by disc diffusion method. The antifungal activity of these compounds was also tested against A. niger and A. flavipes. The results showed that some of the compounds have strong antimicrobial...
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Posted by admin on Jun 1, 2011 in |
Nutritional deficiency is almost impossible to avoid in these modern times, thus natural supplements help us to overcome the nutritional deficiencies. It also helps us to boost our immune system. Nutritional supplements are also useful in getting rid of the toxins that are accumulated in our body. Thus, the five natural supplements that are mentioned below are tested for the various parameters that include the basic Quality Control Parameters, the phyto chemical analysis, Microbial Analysis that includes the testing for the presence of pathogens along with the total bacterial and fungal count. It is also tested for the presence of heavy metals in them, followed by Aflatoxin and Pesticide analysis. The Nutritional Value for each of them were determined and calculated. The actives of Garcinia Capsule, Ginger Capsule and Holy Basil Capsule were confirmed by the HPLC...
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