Posted by admin on Feb 1, 2011 in |
Acute diarrhoea is one of the principal causes of death in the infants, particularly in developing countries. An array of medicinal plants with anti-diarrhoeal properties has been widely used by the traditional practitioners; however, the efficacy of many of these anti-diarrhoeal conventional medicines has not been scientifically evaluated. Hence the present study was under taken to explore anti-diarrhoeal activity of Amorphophallus paeoniifolius leaves. Swiss Albino rats of either sex weighing 150-180 g were used for study and anti-diarrhoeal activity was evaluated by castor oil-induced Diarrhoea model. The ethanolic extract of the A. paeoniifolius leaves, at the doses of 100, 200 and 400 mg/kg, reduced the total number of faeces as well as diarrhoeic faeces in a dose dependent manner and the results were statistically significant (p< 0.05). The investigated may be exploited for wide range of diarrhoeal stages and further studies are needed to completely understand the mechanism of anti-diarrhoeal action of A. paeoniifolius...
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Posted by admin on Feb 1, 2011 in |
Objective: The objective of the study is to design and evaluate oral sustained release tablet of lamotrigine using polymer such as HPMC K 4M, HPMC K 100M and methocel E50 LV at 15%, 25%, and 35% Concentration range. Methods: All the selected ingredients were weighed and passed through 40# sieve, blended in a Poly Bag except Magnesium Stearate for 10 minutes. The resultant mixture was made in to a wet mass and passed through 20# sieve in order to obtain granules. These granules were air dried and passed through 30# sieve. These dried granules were lubricated with Magnesium stearate, which was previously passed through 60# Sieve and then punched using single punching machine. Results: Pre-compression character such as compressibility index, angle of repose and Post-compressional characteristics such as weight variation, hardness, diameter, thickness, friability were found to be with in the I.P limits. In vitro release profile was studied using HPMC K4M, HPMC K 100M and methocel E50 LV at three different concentration. The percentage cumulative amount of drug...
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Posted by admin on Feb 1, 2011 in |
The study was obtained to develop oral controlled release matrix tablets of Lamivudine having different proportion of Guar gum (retardant polymer) and to study the effect of formulation factor such as polymer proportion on the in- vitro release. The prepared granules were evaluated such as angle of repose, loose bulk density, tapped bulk density and compressibility index and satisfactory results were obtained. Compressed tablets were also evaluated for uniformity of weight, content of active ingredient, thickness, friability, hardness, swelling, erosion behaviour and in-vitro dissolution studies. All the formulations showed good results which were compliance with Pharmacopoeial standards. In-vitro drug release studies were carried out using USP XXII dissolution apparatus type II at 50 rpm with 900 ml phosphate buffer solutions (PBS) of pH 6.8, maintained at 37±0.50C. The release kinetics was analyzed using the zero-order, first-order model equation, Higuchi’s square-root equation, and the Korsmeyer-peppas model. In vitro release studies revealed that the release rate decreased with increases in polymer proportion. Matrix tablets containing 15% guar gum (Formulation F2) were...
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Posted by admin on Feb 1, 2011 in |
Purpose: Ciprofloxacin, an antibacterial agent, is having low solubility in aqueous solution and high rate of absorption from the stomach. It is precipitated at alkaline pH which leads to erratic absorption of the drug from small intestine. To overcome these difficulties, many researchers have prepared different formulations of Ciprofloxacin. But till now very few formulations are available from which the drug is absorbed uniformly, so that safe and effective blood level of Ciprofloxacin can be maintained for a prolonged period. To fulfill this requirement, in the present study, a sustained release drug delivery system (hydrogel) has been designed and chemical interaction between Ciprofloxacin and polymer in hydrogel has been studied by FTIR and Raman Spectroscopy. Methods: Ultrasonication method was used for preparation of hydrogel of the Ciprofloxacin, taking Carbopol 934 polymer with drug to polymer weight ratio 1:5. FTIR (400 cm-1 to 4000 cm-1 region) and Raman (140 to 2400 cm-1 region) Spectroscopic studies were carried out and spectra were used for interpretation. Results: From the spectral interpretation, it...
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Posted by admin on Feb 1, 2011 in |
The present study was aimed to evaluate total antioxidant capacities of eleven different commonly consumed aqueous fruit extracts viz. Ananas comosus, Artocarpus heterophyllus, Carica papaya, Citrullus vulgaris, Citrus sinensis, Malus domestica, Manilkara zapota, Musa paradisiaca, Phyllanthus emblica, Psidium guajava and Pyrus communis. The total antioxidant capacity was assessed using phosphomolybdenum method at different concentrations. Total antioxidant capacity was found to be highest in Phyllanthus emblica (197.5μg of ascorbic acid/mg extract) and lowest in Artocarpus heterophyllus (1μg of ascorbic acid/mg extract). The present research programme underlies the total antioxidant potentials of...
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