A series of 1, 3, 4-thiadiazole derivatives were synthesized. The structures of these compounds were established by means of IR, 1H-NMR and mass spectrum analysis. All the compounds were evaluated for antibacterial and antifungal activities. Most of the compounds have shown significant antibacterial and antifungal activity when compared with the standard...
Read MoreAim of study is to evaluate the potential anti-tussive activity in a mouse model induced by sulphur dioxide gas of ethanolic extract of “Rosa centifolia”. The ethanol extract of Rosa centifolia (250mg/kg 500 mg/g p.o) showed significant anti-tussive activity, the cough inhibition (35% and 57% respectively) and being comparable to that of 10-20mg/kg of codeine phosphate (41 and 64% respectively).The effect of ethanolic extract on the trachea was also tested it did not relax pre-contractions in guinea pig trachealis induced by KCl and...
Read MoreThe present investigation was undertaken to study the antimicrobial and antioxidant activity in algae (Chlamydomonas reinhardtii CC 124). The extractions of metabolites were done by two methods (glass bead and steel ball) using methanol: chloroform: water (5:2:2) as solvents. The presences of metabolites were identified by thin layer chromatography and structural analysis was done by Gas Chromatography and Mass Spectrometry. Antimicrobial activities of the extracts were assessed against bacterial and fungal strains (Bacillus subtilis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans, Aspergillus niger, Aspergillus flavus) by disc diffusion method and compared with standard antibiotics. The results, of both extracts showed more potent antimicrobial activity in (B. subtilis,P. aeruginosa, K. pneumoniae) bacterial species and (C. albicans) fungal strain. The antioxidant activity was tested by DPPH (2, 2-Diphenyl-1-picrylhydrasyl) free radical method and determination of H2O2 radical scavenging activities were also performed. The presence of antioxidants was compared with commercial antioxidants, such as BHT (Butylated Hydroxy Toluene), BHA (Butylated Hydroxyl Anisole).The phenolic content was compared with gallic acid. From the present study, it...
Read MoreThe ethanol extract of Hibiscus esculentus Linn roots inhibited the formation of oxygen derived free radicals were screened for their in vitro antioxidant activity. Stems leaves and root of selected plants were dried at 45°C and powdered for extraction. Extraction was performed with methanol. By employing DPPH (2, 2-diphenyl-1picrylhydrazyl radical) scavenging assays, it was shown that all the ethanol extracts of the samples collected show antioxidant activity. Though, as expected, their potency varied according to the different parts and species. In particular, leaves and stems of Hibiscus esculentus leaves displayed the highest activity. The extracts tested ranged from 0.176 mg/mL –2.45mg/mL. It is generally accepted that a diet rich in plants is associated with a reduced incidence of degenerative diseases, such as atherosclerosis and cancer. This study suggests that the Hibiscus esculentus plant could be pharmaceutically exploited for antioxidant...
Read MoreFlaxseed is being consumed as an ingredient in various food formulations as it plays a major role in the field of diet and disease research due to its potential health benefits associated with a- linolenic acid (57%) and its rich phytoestrogens or lignans. Hence, presently, it is in great demand by food industries and in nutraceutical applications. The present study was carried out using 80, 32-weeks old, Single Comb White Leghorn (SCWL) laying hens which were subjected to 4 dietary treatments, namely Control, 5% flaxseed endosperm-rich fraction (ERF), 10% ERF and 20% ERF. At the end of the 4th week, all groups were examined hematologically and histopathologically. There was a linear relationship between feed consumption and decrease in body weight. The decrease in the weight of the birds was directly proportional to the concentration of ERF in the diet. Packed cell volume (PCV) and red blood cell (RBC) counts had a negative significance (p<0.05) linear relationship with the ERF level. There was a decrease in PCV and RBC counts...
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