Posted by admin on Feb 1, 2011 in |
The purpose of the study was to determine the in vitro as well in vivo efficiencies of 1% carbopol hydrogel different preparations containing the meloxicam, a cyclooxygenase-2 inhibitor anti-inflammatory drug with b-cyclodextrin. The release of plain drug was then compared with release of from trans dermal gel containing physical mixture of drug and b-cyclodextrin, inclusion complex of drug and b-cyclodextrin obtained by kneading method and in situ complex of drug and b-cyclodextrin obtained by reacting the drug and b-cyclodextrin within the gel. All solid inclusion complex abstained were then characterized by x-ray diffractrometry, infrared spectroscopy, differential scanning colorimetry and scanning electron microscopy, where as the in situ complex formation was evidenced only by release and permeation studies. Although many other derivative of cyclodextrins such as hydroxy propyl-b-cyclodextrin and methylated-b-cyclodextrin are better skin permeating enhancers but in this study b-cyclodextrin was employed because of ease of availability and low cost. Solid inclusion complex was prepared by kneading method. Gel formulations were prepared by incorporating pure drug, physical mixture, inclusion complex...
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Posted by admin on Feb 1, 2011 in |
New 5- phenyl- 1, 3, 4- oxadiazole- 2- thiol derivative was synthesized by the ring closure reactions of benzohydrazides with carbon disulphide in presence of ethanolic KOH followed by substitution with secondary amines at 2nd position. All the newly synthesized compounds were characterized by IR, NMR and LC-MASS spectral data. Most of them were tested for their anti-inflammatory and antibacterial...
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Posted by admin on Feb 1, 2011 in |
Hormonal changes during the menstrual cycle are well documented but there are very few reports on the changes in serum calcium, phosphorus and uric acid levels in various phases of the menstrual cycle. Therefore, present study was conducted on 50 healthy females in the age group of 18-35 menstruating regularly (cycle length between 25 and 35 days). The study demonstrated that serum calcium levels were significantly (p<0.001) higher in follicular phase than menstrual and luteal phases. Serum inorganic phosphorus levels decreased progressively and significantly (p<0.001) from the menstrual phase to the follicular phase and from the follicular phase to the luteal phase while serum uric acid levels were significantly (p<0.001) lower in luteal phase than the menstrual and follicular phases. These changes in calcium, phosphorus and uric acid in serum may have significance in terms of the normal reference interval, hence necessitate small but significant alterations to the normal reference interval for these analytes in menstruating...
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Posted by admin on Feb 1, 2011 in |
A simple, precise, specific and accurate reverse phase HPLC method has been developed for the determination of Ritonavir in bulk and pharmaceutical dosage forms. The chromatographic separation was achieved on Symmetry C18 (4.6 x 100mm, 3.5 μm) column using a mixture of Buffer: Acetonitrile (50:50) as the mobile phase at a flow rate 1.0 ml/min. Linearity was observed in concentration range of 50-150μg/ml. The retention time of Ritonavir was 5.1 min. The analyte was monitored using UV detector at 239 nm. Results of analysis were validated statistically and by recovery studies. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and...
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Posted by admin on Feb 1, 2011 in |
A considerable number of studies have already been performed involving the roots and stems of Berberis aristata and thus the following investigation has been carried out for the phytochemical study of ethanolic extract of heartwood of Berberis aristata. The heartwood (1.8 kg) of Berberis aristata DC. Var aristata (Berberidaceae) was exhaustively extracted in 95% ethanol using Soxhlet apparatus. The column was prepared for isolating various phytoconstituents using solvents of increasing polarity. On the basis of various spectral data analysis i.e., IR, 1HNMR, 13CNMR and +ve ion FAB MS, one of the isolated phytoconstituents was characterized as an aliphatic hydrocarbon,...
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