Posted by admin on Jun 1, 2011 in |
Digera muricata (L.) Mart (Amaranthaceae) commonly known as Cancali soppu widely used in traditional system of medicine for the treatment of diabetes mellitus In the present study, Methanol extract of Digera muricata(MEDM) leaves were subjected to phytochemical investigation and evaluated for antidiabetic activity in alloxan induced diabetic rats. MEDM (100, 200 mg/kg) and Glibenclamide (3mg/kg) were administered orally in alloxan (140 mg/kg, i.p.) induced diabetic rats. In acute oral toxicity (OECD Guide line 423) study, administration of MEDM no mortality upto 2000 mg/kg was observed. OGTT, Fasting blood glucose level, body weight, lipid profiles, HbA1c, plasma insulin, and ALP were evaluated in normal and diabetic rats. preliminary phytochemical investigation revealed the presence of alkaloids, flavonoids, glycosides, tannins as the major constituents in the methanol extract .These results suggest that MEDM (200mg/kg) showed antihyperglycemic activity in alloxan induced diabetic...
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Posted by admin on Jun 1, 2011 in |
Aim of the present study was to isolate and characterize the biochemical principle and investigate the hypoglycemic activity of bark of Alangium salviifolium Wang in Alloxan induced hyperglycemic rats. The bark of Alangium salviifolium barks were collected and dried in shade and subjected to extraction with petroleum ether, Chloroform and methanol. Each extracts were subjected to preliminary phytochemical analysis. Petroleum ether and Chloroform extract were subjected to chromatography. Two compounds were isolated and purified by alcohol then, subjected to physical and spectral studies. Spectral results revealed that isolated compounds may be phytosteroids. Hypoglycemic activity was performed by alloxan induced method. MEAS were administered orally to the hyperglycemic induced rats at the dose of 250mg/kg, 500mg/kg and 750mg/kg. Glibenclamide was used as reference drug. Then blood glucose levels were measured at the time interval of 30 mins, 1, 2, 3, 4 hrs and 8hrs by one touch glucometer. Then blood samples were collected from all rats and evaluated for biochemical parameter. Significant reductions in the blood glucose levels were observed....
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Posted by admin on Jun 1, 2011 in |
For many decades treatment of an acute disease or a chronic illness has been mostly accomplished by delivery of drugs to patients using various pharmaceutical dosage forms including tablets, capsules, pills, suppositories, creams, ointment, liquids, aerosols and injectables as drug delivery systems are the primary pharmaceutical products commonly seen in the market. In the past two and a half decades several advancements has been made in the pharmaceutical products. They have resulted in the development of new techniques for drug delivery1. These techniques are capable of controlling the rate of drug delivery, sustaining the duration of therapeutic activity and targeting the delivery of drug. A series of three different trial formulation of Rabeprazole Sodium, Microsphere using Chitosan an aminopolysaccharide, so as to optimize the sustained conditions. In the case of microsphere, the initial formulation was done with 0.5% Chitosan solution and drug. Then the concentration of chitosan had been increased to 1.5%. It showed that the percentage release was maximum 65.2% for the chitosan microsphere in the formulation F3,...
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Posted by admin on May 1, 2011 in |
As the psychotic, pediatric and geriatric patients are unable to swallow the medicine mouth dissolving drug delivery systems are designed for rapid dissolution and absorption of drug in the mouth within minutes without the need of water or chewing. Olanzapine is water insoluble drug hence to make it solubilize it is formulated as drug- polymer inclusion complex by using. The aim of the present study was to formulate olanzapine orodispersible tablets by using β-cyclodextrin and superdisintegrants to enhance the solubility of the drug. The drug, polymer and inclusion complex were investigated for drug interactions, complex formation and change in crystallinity by using infrared, differential scanning calorimetry, x-ray diffraction and the tablets were developed by using the direct compression and were investigated for in-vitro dissolution behavior and drug content. β-cyclodextrin (1:1M) can be used to enhance the solubility and dissolution rate of the drug. AC-DC-SOL (crosscarmellose sodium) as a super disintegrant shows faster release than both control and formulation by other superdisintegrants for quick release of the drug from the...
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Posted by admin on May 1, 2011 in |
Background: Parasitic helminth infection is one of the major risk factors underlying the high rates of anaemia and malnutrition in many third world countries due to the poor socio-economic and environmental conditions of the people and these play a very significant role in their transmission. Method: 2000 stool specimens collected between May and October 2008 at the Komfo Anokye Teaching Hospital in Ghana were screened using the Kato-Katz and formol-ether concentration methods for the presence of intestinal helminthes. Prior to sample collection, histories of any antihelmentic drug usage in the last three months preceding this study were collected. Hookworm positive stool specimens were further cultured by the modified Harada-Mori test-tube technique for the identification of the hookworm filariform larvae. Results: Hookworm (Necator americanus) was the most prevalent helminth parasite (2.9%) found in the study. Other parasitic helminthes detected were Dicrocoelium dendriticum (2.1%), Strongyloides stercoralis (2.1%), Schistosoma mansoni (1.8 %), Hymenolepis nana, (1.4%) Taenia species (0.6%) and Trichuris trichuria (0.1%). S. mansoni infection was however high among patients aged between...
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