Posted by admin on Jan 1, 2011 in |
Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostasis resulting in severe diabetic complicationsincluding retinopathy, angiopathy, nephropathy, neuropathy and causing neurological disorders due to perturbation in utilization of glucose. In the present study diabetes was induced in albino rat models with alloxan monohydrate. Putranjiva roxburghii Wall. has been claimed to possess antidiabetic properties by many investigators. The present study was undertaken to screen the hypoglycemic activity of ethanol extracts of leaves of Putranjiva roxburghii. The results showed that it has significant antihyperglycemic effect in experimental model of diabetes...
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Posted by admin on Jan 1, 2011 in |
HER2 stands for Human Epidermal growth factor Receptor 2. Each normal breast cell contains copies of the HER2 gene coding for HER2 protein found on the cell surface, which helps normal cells grow.HER2+ breast cancer is characterized by over expression of this gene in breast cells which fosters the cell growth giving rise to breast tumors. Studies show that 20-25% of breast cancer patients have tumors that are HER2+ making it a significant target for breast cancer studies. Identification of effective, well tolerated HER2 inhibitors represents a rational chemo preventive strategy. Here I present a study on the 27 herbal HER2 targeted lead compounds and their potential binding affinity to HER2. Iressa and Lapatinib served as reference drugs. Lipinski’s rule of five was applied to all the herbal compounds to evaluate their drug likeness, pharmacological or biological activity. Depending on Lipenski’s rule, the molecules which were following the criteria for the same were subjected to energy minimization using MARVIN SKETCH and receptor-ligand interaction study using QUANTUM docking tool. Reference drugs were also subjected...
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Posted by admin on Jan 1, 2011 in |
Tablet disintegration has received considerable attention as an essential step in obtaining fast drug release. Disintegrating tablets are intended to dissolve or disintegrate rapidly in the mouth for which various natural and synthetic disintegrants are included in the formulation. The present work emphasis on the study of disintegrant property of mucilage, Husk powder and seed powder of Isapghula. The Orally disintegrating tablet of Fexofenadine HCl (as model drug) was prepared by direct compression method using microcrystalline cellulose and Mannitol as direct compressible vehicle. These tablets were evaluated for quality control tests like organoleptic characteristics, weight variation, hardness, friability, in-vitro disintegration time, in-vitro swelling time, drug content and dissolution behavior. Swelling index was also investigated with an aim to compare the swelling property of seed powder, husk powder and mucilage of Plantago ovata. Among all the superdisintegrants, Plantago ovata mucilage showed the highest swelling index. Hence, the present study revealed that this natural superdisintegrant (Plantago ovata mucilage) showed similar disintegrating property than the most widely used synthetic superdisintegrants in the...
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Posted by admin on Jan 1, 2011 in |
The aim of the study was to evaluate the circulating antioxidant such as vitamin C, vitamin E and GSH in nickel (Ni) induced toxicity in rats and in vitro free radical scavenging assay. In this investigation nickel sulfate (20 mg/kg body weight (b.w.) was administered intraperitoneally (i.p.) for 20 days to induce toxicity. Naringin was administered orally (80 mg/kg body weight) for 20 days with i.p. injection of nickel sulfate. The toxic effect of nickel was indicated by significantly decreased activities of non-enzymatic antioxidants like reduced glutathione, vitamin C and vitamin E. Treatment with naringin exhibited a significant (P < 0.05) increase in Ni-induced rats. The free radical scavenging properties of naringin were investigated with different in vitro methods such as 2, 2¢- diphenyl- 1-picrylhydrazyl radical (DPPH•), 2, 2’- azinobis (3-ethylbenzo thiazoline- 6- sulfonic acid) radical (ABTS•+), hydroxyl radical, superoxide anion scavenging activity and reducing power. In addition to that ascorbic acid, butylated hydroxyl toluene was used as the reference antioxidant radical scavenger compounds. Among the different concentration, 500...
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Posted by admin on Jan 1, 2011 in |
Plants are the local heritage with global importance. World is endowed with a rich wealth of medicinal plants. They represent and alternative treatment of non-serve cases of infections diseases. They are also the essential an integral part in complementary and alternative medicine and due to they which have developed the ability for the formation of various phytochemicals like terpenoids, steroids, flavonoids, tannins, phenols, saponin, cardio glycosides, carbohydrates, alkaloids, amino acids and proteins substances which are in turn used to restore health and heal many diseases. Natural products of plant and animal origin offer vast resource of newer medicinal agents with potential in clinical use. The present study was an attempt to analyse the phytochemical analysis of Aegle marmelos, Ruta graveolens, Opuntia dellini, Euphorbia royleana, Euphorbia antiquorum infive different solvent extracts. Some of the plants extracts have shown presence of...
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