Posted by admin on May 1, 2011 in |
Hemangiomas are abnormal accumulation or growth of blood vessels in the internal organs or in the skin. Most hemangiomas occur at birth while others develop after birth. There are two types of hemangiomas the capillary hemangioma and the cavernous hemangioma. A capillary hemangioma is usually seen at the top layer, while the cavernous hemangioma is often found at the deeper layer. Some patients, however, may present with both types. The cavernous hemangioma, also known as cavernoma, occurs less commonly than the capillary hemangioma. It is a benign tumor of blood vessels that rapidly grows over a period of time and does not usually reduce in size. Most cavernous hemangiomas are usually soft to the touch. Hemangiomas are common vascular, childhood benign tumors with special predilection to head & neck region. Benign vascular tumors are fairly common with wide distribution through the body. They may be single or multiple. They may occur in combination, affecting a number of organs and producing well known syndromes but vascular tumors of the female...
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Posted by admin on May 1, 2011 in |
The present study was designed to investigate the antibacterial activity and free radical scavenging potential of methanloic extract of Pterocarpus santalinus (PSMExt). Significant MIC was observed against Bacillus subtilis (0.312 mg/ml). Free radical scavenging potential of PSMExt was evaluated by using total antioxidant activity (thiocyanate method), diphenyl-picryl-hydrazyl (DPPH) assay and nitric oxide (NO) assay. Results of the present study disclosed that PSMExt showed remarkable and concentration dependent free radical scavenging activity. Phytochemical analysis showed the presence of flavonoids, terpenoids and steroids. The present work indicated that the methanolic extract of Pterocarpus santalinus was capable of scavenging the free radicals and inhibited the tested bacteria, suggested the potential antibacterial and antioxidant...
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Posted by admin on May 1, 2011 in |
A simple and sensitive extractive spectrophotometric method has been described for the assay of Mianserin hydrochloride (M-HCl) either in pure form or in pharmaceutical solid dosage form. The developed method involves formation of colored chloroform extractable ion-association complex of Mianserin hydrochloride (M-HCl) with Picric acid (PA), Chlorophenol red (ClPR), Bromthymol blue (BrTB), Bromcresol purple (BrCP) reagents. The extracted complexes showed absorbance maxima at optimum wavelength using visible spectrophotometer. Beer’s law is obeyed in the concentration range of 1-42 μg/mL. Correlation coefficient was found to be ≥ 0.9985. In addition we have determined the molar absorptivity, Sandell sensitivity and the optimum conditions for quantitative analysis of the investigated...
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Posted by admin on May 1, 2011 in |
The World Health Organization estimates that a staggering two billion people harbor parasitic worm infections. Parasitic worms also infect livestock and crops, affecting food production with a resultant economic impact. Despite this prevalence of parasitic infections, the research on antihelmentic drug is poor. As per WHO, only few drugs are frequently used in the treatment of helminthes in human beings. Antihelmentic from the natural sources may play a key role in the treatment of these parasitic infections. In view of this petroleum ether (60-80º C) and ethanolic extracts of aerial parts of Enicostemma littorale Blume were evaluated separately for the activity on adult Indian earthworms, Pheretima posthuma, using albendazole as reference standards. Five concentrations (2.5, 5, 10, 25 & 50 mg/ml) of each extracts were studied in activity, which involved the determination of time of paralysis and time of death of the worm. The results indicated that the ethanolic extract was more potent than the petroleum ether...
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Posted by admin on May 1, 2011 in |
Withania somnifera L. Dunal (Family: Solanaceae) is extensively used in traditional Indian medicine as a nerve tonic and is thought to improve memory. We assessed the acetylcholinesterase (AChE) inhibitory activity and kinetics of an aqueous extract of W. somnifera root, in the context of its potential role in regulating the levels of acetylcholine (ACh) in the brain. The assessment of cholinesterase inhibition was carried out using a colorimetric method based on Ellman’s reaction. Our findings demonstrate that W. somnifera extract significantly inhibited AChE in a concentration-dependent manner. A 1mg/mL extract concentration resulted in an 86% inhibition as compared with control. The IC50 value was 0.15mg/mL calculated from the equation of the percentage inhibition curve for the test extract. The Lineweaver-Burk plot indicated that the extract followed mixed non-competitive inhibition kinetics. We conclude that the mode of action exhibited by the aqueous extract of W. somnifera root has a potential therapeutic application that might be beneficial in improving memory and other cognitive functions associated with the cholinergic...
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