Posted by admin on Jan 1, 2011 in |
In the present study, eight organic solvents and aqueous extracts of Canavalia mollis leaves were screened for their phytochemical composition, anti bacterial and free radical scavenging activities. Among the different extracts tested, ethanol, methanol and acetone extracts showed significant antimicrobial and radical scavenging activities. The most susceptible microorganisms were found to be Escherichia coli, Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, and Streptococcus faecalis. Preliminary phytochemical analysis of the leaf extracts revealed that the antibacterial and the radical scavenging activities are mainly due to the presence of the phenolic compounds especially alkaloids. The results obtained suggest that C. mollis could be exploited in the infections management of various...
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Posted by admin on Jan 1, 2011 in |
Capparis grandiflora was used to treat diarrhoea and other infective disorders in folklore. The present study aims at evaluating the action of chloroform soluble fraction, ethanol soluble fraction and ether soluble fraction of the leaves of Capparis grandiflora against inflammatory diseases. The anti-inflammatory effects were investigated by employing acute inflammatory model i.e.; carrageenan-induced hind paw oedema and formaldehyde-induced hind paw oedema in rats. The ethanol soluble fraction was found to be the most potent among them which shows good anti-inflammatory response with reference to the standard drug...
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Posted by admin on Jan 1, 2011 in |
Bambuterol HCl is a potent anti-asthmatic agent, act by stimulation through beta-adrenergic receptors of intracellular adenylcyclase. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells. In the present study, an attempt has been made to prepare fast dissolving tablets of Bambuterol HCl in the oral cavity with enhanced dissolution rate and to achieve better patient compliance. The tablets were prepared with four superdisintegrants e.g., Sodium starch glycolate, Cross-povidone, Cross-carmellose sodium, Pregelatinized starch by direct compression method. The pre-compression parameters of mixed blend were examined for angle of repose, bulk density, tapped density, Compressibility index and Hausner’s ratio. The tablets were evaluated for hardness, friability, weight variation, disintegration time, dissolution rate, content uniformity and drug content. It was concluded that the fast dissolving tablets with proper hardness, rapidly disintegrate with enhanced dissolution can be made using selected superdisintegrants. Among all formulations, batch D4 was considered as best since it showed enhanced dissolution,...
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Posted by admin on Jan 1, 2011 in |
Dissolution rate enhancement of alprazolam, an anti-anxiety drug, was done by preparing solid dispersions by solvent evaporation method .Polyethylene glycol 6000 and Polyvinyl pyrrolidone k-30 were selected as carriers. Drug: Polymer ratios were taken as 1:1,1:2and1:4 for both the polymers for the preparation of solid dispersions. Tablets were prepared from solid dispersions and also from physical mixtures by direct compression. Dissolution rates and drug releases of solid dispersions or their tablets were found more than those of corresponding physical mixtures or their...
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Posted by admin on Jan 1, 2011 in |
This study describes development and subsequent validation of a reversed phase high performance liquid chromatographic (RP-HPLC) method for the estimation of ursodeoxycholic acid used to solubilize cholesterol gallstones, in conventional tablet dosage formulation and in prepared dosage form. The chromatographic system was achieved in a BDS Hypersil C8 column (Thermo, 250mm x 4.6 mm, 5 µ) with an isocratic mobile phase comprising of methanol, water and phosphoric acid (77:23:0.6 v/v). Since the drug shows moderate absorption only in the short UV wavelength region (200-210 nm), quantification of the amount released from the pharmaceutical preparations by simple UV spectrophotometry is hampered by possible interferences from formulation excipients and dissolution medium components. A new method has been developed utilizing the above mobile phase and detection in refractive index (RI) detector. In this chromatographic condition ursodeoxycholic acid was eluted about 3.0 min with no interfering peaks of excipients used for the preparation of dosage forms. The method was linear over the range from 240-360 µg/mL in raw drug (r2 = 0.995). The...
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