Posted by admin on Oct 1, 2010 in |
This study evaluated the in vitro antioxidant and cytotoxic potential of methanolic extract of the rhizome of Costus speciosus (Zingiberaceae). The different antioxidants assays including total antioxidant activity, DPPH, nitric oxide (NO) scavenging, total phenolic content and flavonoid content were studied. Costus speciosus exhibited potent total antioxidant activity which was expressed as an equivalent of ascorbic acid mg/g plant extract. In addition, Costus speciosus had effective free radical scavenging, nitric oxide scavenging activity, total phenolic content and flavonoid content depending on concentration. These various antioxidant activities were compared with the standard antioxidants ascorbic acid and quercetin. The extract of the rhizome of Costus speciosus also demonstrated a strong cytotoxic activity against brine shrimp nauplii with an LC50 value of 31.55...
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Posted by admin on Oct 1, 2010 in |
The dried aerial parts of Cardiospermum halicacabum Linn were subjected to extraction using the solvents (petroleum ether, chloroform, Ethyl acetate and ethanol) in increasing order of polarity. The prepared extracts were then subjected to preliminary phytochemical analysis. It was found plant possesses carbohydrates, alkaloids, sterols, flavanoids and saponins. All extracts were selected for further study. The analgesic activity of all extracts of aerial parts was assessed in albino mice using thermal stimulus model. morphine and Paracetamol were used as standard. The results indicate that, petroleum ether extract showed 34% (0.15mg/ml) and 58 %( 0.3mg/ml) significant activity, when compared with morphine. Comparison with Paracetamol the pet ether extract showed 48% (0.3mg/ml) and 82% (0.3mg/ml) significant activity. The ulcer activity was determined by pylorus ligation technique. Ranitidine (50mg/kg) used as standard. The ethanol extract showed 48.2% (18.75mg/2ml) significant antiulcer activity compared with standard drug. From the present study it may be concluded that the constituents present in all the extracts may be responsible for both...
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Posted by admin on Oct 1, 2010 in |
The present study was undertaken to evaluate antioxidant and hypolipidemic activity of Vedic guard, a polyherbal formulation comprising of Terminalia arjuna, Withania sominefera, Bacopa monnierii, Tinosporia cardifolia, Commiphora mukul and many other plant extracts, all of which are classifieds in Ayurveda as Rasaayanas which are reported to promote antioxidant and hypolipidemic activity. Antioxidant activity has been established in young adult rats against antitubercular drug induced hepatotoxicity but not in geriatric rats. Antioxidant activity was evaluated by hepatoprotectivity against carbon tetrachloride induced liver toxicity for 21 days in geriatric rats using Silymarin as reference standard, and by pyrogallol induced immunosupression for 28 days in young adult rats using levamisole as reference standard. Hypolipidemic activity was evaluated using triton WR1339 induced hyperlipidemic rats as experimental model in acute study. Oxidative damage was evidenced by occurrence of liver cirrhosis, elevation of AST, ALT, and ALP, total bilirubin in blood serum and increased LPO, reduced CAT and GSH in liver homogenate. Vedic guard treatment in geriatric rats with doses of 90mg/kg, 180mg/kg b....
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Posted by admin on Oct 1, 2010 in |
Directly compressible co-processed sustained release multifunction agent [DCCSRA] comprising povidone and glyceryl behenate in the ratio of 1:1, 1:2 and 1:3 were prepared and evaluated for formulation of sustained release tablets of isosorbide mononitrate. The DCCSRA exhibited good flow and compressibility. The DCCSRA, prepared by hot melting method and co-precipitation method served as a retardant, binder and lubricant in isosorbide mononitrate sustained release tablets. The DCCSRA may be used for manufacturing of isosorbide mononitrate sustained release...
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Posted by admin on Oct 1, 2010 in |
Carvedilol, a non selective β blocking drug under the biopharmaceutical classification system (BCS) class II, is widely used in the treatment of hypertension. Solubility of this drug is very low which affects in low dissolution rate and in turn affect the bioavailability of this drug following oral administration. The micronization of drug is one of the technological procedures to improve the dissolution rate. The purpose of the present study is to design a sustained release matrix tablet containing micronized carvedilol phosphate. Phospahte salt of carvedilol possesses better aqueous solubility than it’s free base. Hydroxy propyl substituted β cyclodextrin and poly ethylene oxide are used as release modifying polymer to develop the matrix tablet. The comparative in vitro evaluation between the developed micronized sustained release and non-micronized sustained release matrix tablet of carvedilol are done. A significant increase in in vitro drug release rate is observed in case of the micronized product over the non micronized one. The sustained release matrix tablet of micronized carvedilol may be used as a...
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