Posted by admin on Feb 1, 2011 in |
The antibacterial properties of methanol leaf extract of Duranta plumieri wasdeterminedagainst Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabilis and Bacillus subtilis as test organisms using the agar disc diffusion method. The minimum inhibitory concentrations were determined using the microbroth dilution method. The methanol extract was subjected to preliminary phytochemical analysis. Free radical scavenging activity of the methanol extract at different concentrations was determined with 2, 2-diphenyl-1picrylhydrazyl (DPPH). E. coli, Staph. aureus, Kl. pneumoniae, B. subtilis and Pr. mirabilis were susceptible to D. plumieri extract with minimum inhibition concentrations of 48 mg/ml, 192 mg/ml, 192 mg/ml, 12 mg/ml and 96 mg/ml respectively. The extract had no activity against Ps. aeruginosa. Alkaloids, glycosides, saponins, steroids and polyphenols (tannins and flavonoids) were detected as phytoconstituents of the methanol...
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Posted by admin on Feb 1, 2011 in |
Earthworm plays a major role in the proper functioning of the soil ecosystem. It acts as scavenger and helps in recycling of dead and decayed plant material by feeding on them. Earthworm increases the soil fertility and is often referred to as a farmer’s friend. Earthworms have been used in medicine for various remedies. In the present investigation, various solvent extracts of an earthworm, Eudrilus eugeniae were prepared and anti-inflammatory activity of these extracts were determined. The petroleum ether fraction possessed maximum anti-inflammatory activity in carrageenan induced albino rats in comparison to 95% ethanol and 0.2 M phosphate buffer (pH, 7.0) extracts. The paw volume was determined and was compared with that of aspirin, a standard anti-inflammatory drug. The results indicates that petroleum ether fraction of earthworm extract possessed similar anti-inflammatory activity as that of...
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Posted by admin on Feb 1, 2011 in |
Acute diarrhoea is one of the principal causes of death in the infants, particularly in developing countries. An array of medicinal plants with anti-diarrhoeal properties has been widely used by the traditional practitioners; however, the efficacy of many of these anti-diarrhoeal conventional medicines has not been scientifically evaluated. Hence the present study was under taken to explore anti-diarrhoeal activity of Amorphophallus paeoniifolius leaves. Swiss Albino rats of either sex weighing 150-180 g were used for study and anti-diarrhoeal activity was evaluated by castor oil-induced Diarrhoea model. The ethanolic extract of the A. paeoniifolius leaves, at the doses of 100, 200 and 400 mg/kg, reduced the total number of faeces as well as diarrhoeic faeces in a dose dependent manner and the results were statistically significant (p< 0.05). The investigated may be exploited for wide range of diarrhoeal stages and further studies are needed to completely understand the mechanism of anti-diarrhoeal action of A. paeoniifolius...
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Posted by admin on Feb 1, 2011 in |
Objective: The objective of the study is to design and evaluate oral sustained release tablet of lamotrigine using polymer such as HPMC K 4M, HPMC K 100M and methocel E50 LV at 15%, 25%, and 35% Concentration range. Methods: All the selected ingredients were weighed and passed through 40# sieve, blended in a Poly Bag except Magnesium Stearate for 10 minutes. The resultant mixture was made in to a wet mass and passed through 20# sieve in order to obtain granules. These granules were air dried and passed through 30# sieve. These dried granules were lubricated with Magnesium stearate, which was previously passed through 60# Sieve and then punched using single punching machine. Results: Pre-compression character such as compressibility index, angle of repose and Post-compressional characteristics such as weight variation, hardness, diameter, thickness, friability were found to be with in the I.P limits. In vitro release profile was studied using HPMC K4M, HPMC K 100M and methocel E50 LV at three different concentration. The percentage cumulative amount of drug...
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Posted by admin on Feb 1, 2011 in |
The study was obtained to develop oral controlled release matrix tablets of Lamivudine having different proportion of Guar gum (retardant polymer) and to study the effect of formulation factor such as polymer proportion on the in- vitro release. The prepared granules were evaluated such as angle of repose, loose bulk density, tapped bulk density and compressibility index and satisfactory results were obtained. Compressed tablets were also evaluated for uniformity of weight, content of active ingredient, thickness, friability, hardness, swelling, erosion behaviour and in-vitro dissolution studies. All the formulations showed good results which were compliance with Pharmacopoeial standards. In-vitro drug release studies were carried out using USP XXII dissolution apparatus type II at 50 rpm with 900 ml phosphate buffer solutions (PBS) of pH 6.8, maintained at 37±0.50C. The release kinetics was analyzed using the zero-order, first-order model equation, Higuchi’s square-root equation, and the Korsmeyer-peppas model. In vitro release studies revealed that the release rate decreased with increases in polymer proportion. Matrix tablets containing 15% guar gum (Formulation F2) were...
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