Posted by admin on Sep 1, 2010 in |
Alzheimer’s disease, a synonym for life threatening dementias is characterized by oxidative stress and neuroinflammation induced neuronal loss, impaired energy metabolism, and cholinergic deficit leading to severe cognitive impairments and other abnormal neuropsychiatric changes. Cholinergic hypothesis is the most accepted theory explaining pathology of AD and Acetylcholinestrase inhibitors are the main stay of AD therapy. In the present study, the effect of Minocycline, a tetracycline derivative, was investigated against intracerebroventricular streptozotocin induced cholinergic deficits. Intracerebroventricular administration of streptozotocin (3mg/kg) bilaterally on day 1 and 3 was able to produce significant cholinergic deficits as evidenced by increase in level of acetylcholinestrase while chronic treatment with Minocycline (10, 20 and 40mg/kg, i. p.) for 21 days significantly decreased it. The results of the present study support the candidature of Minocycline in learning and memory disorders resembling dementia of Alzheimer’s...
Read More
Posted by admin on Sep 1, 2010 in |
The anti-allergic of an aqueous extract of the leaves of Ailanthus excelsa Roxb.(AELAq) was evaluated by using milk induced leucocytosis and eosinophilia in mice, passive paw anaphylaxis in rats models while the anticataleptic properties was evaluated by Clonidine induced catalepsy in mice mode. The extract significantly (*p<0.05, **p< 0.01) decreased the leucocytosis and eosinophilia along with passive paw anaphylaxis in the above experimental animals respectively. The extract also significantly (**p< 0.01) decreased Clonidine induced catalepsy in mice. These results suggest that aqueous extract AELAq may have the potential therapeutic value in the treatment of allergic diseases and to produce adaptogenic properties....
Read More
Posted by admin on Sep 1, 2010 in |
The aim of the present research work is to evaluate the impact of superdisintegrants in the formulation and evaluation of rapidly disintegrating tablets. In the present study, Loratadine is the model drug. Rapidly disintegrating tablets of Loratadine was prepared by direct compression method. In this method the different excipients used were Calcium Silicate (FM1000), Pharmattose DCl-21 (anhydrous lactose), Citric acid(anhydrous), Colloidal Silica (Aerosil), Sodium stearyl fumarate, Magnesium Stearate, Crosscarmellose Sodium (AcDiSol), L-HPC( Low substituted hydroxyl propyl cellulose), Microcrystalline Cellulose (Avicel pH-200), Aspartame, Orange flavor and Strawberry flavor. The formulations containing Crosscarmellose sodium and Low substituted hydroxyl-propyl-cellulose as superdisintegrants, disintegrated faster compared to the formulation containing Microcrystalline Cellulose (Avicel pH-200). Pre compression and post compression parameters were evaluated for all eight formulations (F1-F8).Infra-Red study revealed that all polymers and excipients used were compatible with the drug. In vitro drug release showed that almost drug was release in the range of 94-97% range in 10 minutes. Depending upon cumulative drug release, in vitro disintegration time, wetting time results, one formulation F8...
Read More
Posted by admin on Aug 15, 2010 in |
Carvedilol is used for hypertension, angina pectoris and in symptomatic heart failure. It has a short half life of 2h and bioavailability of 25%. Therefore the present investigation is concerned with the development of the buco-mucoadhesive films, which were designed to prolong the buccal residence time, to increase penetration through buccal mucosa and thus increase the bioavailability and its half life. Various formulations were developed by using release rate controlling film forming polymers like Eudragit RL-100, PVP, HPMC, NaCMC and Carbopol 934 in various combinations by solvent casting technique using plasticizer propylene glycol with and without penetration enhancers like DMSO, Tween 60 and castor oil. For unidirectional release, backing layer using ethyl cellulose 10%w/v in ethanol incorporated with propylene glycol as a plasticizer was casted on the films. The most satisfactory formulations had retained on buccal cavity for maximum duration of 10h, released for longer duration of dissolution beyond 12h which had maximum drug permeated during ex-vivo studies. During ex-vivo diffusion studies contributed formulation consisting DMSO as penetration enhancer...
Read More
Posted by admin on Aug 15, 2010 in |
A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of Diphenhydramine Hydrochloride in soft gelatin capsule dosage form. For UV spectrophotometric method, maximum absorption was found at λmax 258nm.The percentage recovery of Diphenhydramine Hydrochloride ranged from (98.97 ± 0.2989) in capsule dosage form. The developed method was validated as per ICH guidelines with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 10-100μg/ml having line equation y = 0.016x – 0.018 with correlation coefficient of 0.9934. By treating the data statistically and by recovery study, results of study were...
Read More
