Posted by admin on Jan 1, 2011 in |
The ethanolic extract of bark of Dalbergia sissoo Roxb. was investigated for its activity against Indian earthworms Pheretima posthuma and nematode Ascardi galli. Various concentrations (10, 20, 50 mg/ml) of ethanolic extract were tested, which involved determination of time of paralysis and time of death of the worms. It was compared with Piperazine citrate (15 mg/ml) and Albendazole (20 mg/ml) as standard reference and normal saline as control. The study indicated the potential usefulness of Dalbergia sissoo Roxb. against helminthic...
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Posted by admin on Jan 1, 2011 in |
The aim of this study was to evaluate the anti-ulcerogenic activity of aqueous extract of Areca catechu L in ethanol induced ulcer model in Sprague Dawley Rats. For possible mechanism of anti-ulcerogenic potential, determination of ulcer index was done using the Merazzi-Uberti and Turba method. Also, analytical method was used to test the 10% homogenate preparation of mucosa of the glandular stomach for protein content and glutathione level. The Sprague Dawley Rats were divided into five groups. Group I was the Normal Untreated group. Group II was the alcohol treated group. Group III was the alcohol treated group and protected group using Areca nut extract 1 g/kg.bwt. Group IV was the alcohol treated group and protected using Areca nut extract 2g/kg.bwt. Group V was the alcohol treated group and protected using the positive control Ranitidine 50 mg/kg.bwt .The paper details the rationale of using Areca nut extract to protect the animals from ulcer formation. In conclusion, aqueous extract of areca nut showed potential anti-ulcerogenic effect compared to Ranitidine, which...
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Posted by admin on Jan 1, 2011 in |
Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostasis resulting in severe diabetic complicationsincluding retinopathy, angiopathy, nephropathy, neuropathy and causing neurological disorders due to perturbation in utilization of glucose. In the present study diabetes was induced in albino rat models with alloxan monohydrate. Putranjiva roxburghii Wall. has been claimed to possess antidiabetic properties by many investigators. The present study was undertaken to screen the hypoglycemic activity of ethanol extracts of leaves of Putranjiva roxburghii. The results showed that it has significant antihyperglycemic effect in experimental model of diabetes...
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Posted by admin on Jan 1, 2011 in |
HER2 stands for Human Epidermal growth factor Receptor 2. Each normal breast cell contains copies of the HER2 gene coding for HER2 protein found on the cell surface, which helps normal cells grow.HER2+ breast cancer is characterized by over expression of this gene in breast cells which fosters the cell growth giving rise to breast tumors. Studies show that 20-25% of breast cancer patients have tumors that are HER2+ making it a significant target for breast cancer studies. Identification of effective, well tolerated HER2 inhibitors represents a rational chemo preventive strategy. Here I present a study on the 27 herbal HER2 targeted lead compounds and their potential binding affinity to HER2. Iressa and Lapatinib served as reference drugs. Lipinski’s rule of five was applied to all the herbal compounds to evaluate their drug likeness, pharmacological or biological activity. Depending on Lipenski’s rule, the molecules which were following the criteria for the same were subjected to energy minimization using MARVIN SKETCH and receptor-ligand interaction study using QUANTUM docking tool. Reference drugs were also subjected...
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Posted by admin on Jan 1, 2011 in |
Tablet disintegration has received considerable attention as an essential step in obtaining fast drug release. Disintegrating tablets are intended to dissolve or disintegrate rapidly in the mouth for which various natural and synthetic disintegrants are included in the formulation. The present work emphasis on the study of disintegrant property of mucilage, Husk powder and seed powder of Isapghula. The Orally disintegrating tablet of Fexofenadine HCl (as model drug) was prepared by direct compression method using microcrystalline cellulose and Mannitol as direct compressible vehicle. These tablets were evaluated for quality control tests like organoleptic characteristics, weight variation, hardness, friability, in-vitro disintegration time, in-vitro swelling time, drug content and dissolution behavior. Swelling index was also investigated with an aim to compare the swelling property of seed powder, husk powder and mucilage of Plantago ovata. Among all the superdisintegrants, Plantago ovata mucilage showed the highest swelling index. Hence, the present study revealed that this natural superdisintegrant (Plantago ovata mucilage) showed similar disintegrating property than the most widely used synthetic superdisintegrants in the...
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