Posted by admin on Dec 1, 2010 in |
Aceclofenac is an analgesic and anti-inflammatory agent used in the management of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. The objective of the present work was to investigate the effect of different types of carriers such as polyvinyl pyrrolidone (PVP), polyethylene glycol (PEG) 6000 and sodium lauryl sulphate (SLS) as solubilizer on in vitro dissolution of aceclofenac. Aceclofenac solid dispersions were prepared using 3² factorial design by fusion and solvent evaporation method with PEG 6000, PVP & SLS. Prepared aceclofenac solid dispersions were evaluated for physical appearance, drug content uniformity, and in vitro dissolution studies. The dissolution was determined by USP XXIII apparatus using phosphate buffer pH 7.4. The highest aceclofenac dissolution rate, 99.87% in 60 minutes, was obtained from solid dispersion containing SLS (ASS7) prepared by solvent evaporation method. The general trend indicated that there was an increase in dissolution rate for solid dispersions prepared in following order SLS>PVP>PEG 6000. IR and DSC studies showed no chemical change between drug and polymer and aceclofenac is homogeneously distributed in an...
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Posted by admin on Dec 1, 2010 in |
Ailanthus altissima Swingle (Simaroubaceae) is commonly known as “Tree of heaven”. The methanolic extract of root bark of A. altissima (MEA) was taken for anti-diarrhoeal activity. Investigations were carried out on castor oil induced diarrhoea and small intestine transit method on mice. In former method, MEA 200 (mg/Kg) were reducing the total weight of the faeces of group (0.163±0.028) in comparison to control group faeces (0.652±0.041), were statistically significant (P<0.001). In latter method, the MEA 200 (mg/Kg) inhibited 72.414% of the distance travelled by the charcoal and were significant statistically...
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Posted by admin on Dec 1, 2010 in |
This paper describes the analytical method suitable for validation of Candesartan Cilexetil (CDN) by reversed Phase liquid chromatography (RP-LC) method. The method utilized RP-LC (Shimadzu LC-10AT with UV detector) model and Hypersil ODS C-18 (250 x 4.6 mm, packed with 5 micron) column was used for the separation. The mobile phase was consists of acetonitrile:0.05 M KH2PO4 buffer in the ratio of 65:35 at flow rate of 1.5 ml/ min. Validation experiments were performed to demonstrate System suitability, Specificity, Precision, Linearity, Accuracy study. The method was linear over the concentration range of 0.5-400 mg/ml. The method showed good recoveries (99.54- 100.41%) and the recovery studies were carried out by adding different amounts (80%, 100% & 120%) of bulk samples of Candesartan cilexetil along with internal standard were 100.04%, 99.98% & 99.64% respectively. The proposed method is Precise, Accurate, Reproducible and rapid for the determination of Candesartan cilexetil in bulk and their pharmaceutical dosage...
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Posted by admin on Dec 1, 2010 in |
The present investigation deals with the development of a new, simple, specific, sensitive, rapid and economical procedure for simultaneous estimation of Carvedilol in its dosage form. The method is based on the ultraviolet absorbance maxima of the above drug at 285 nm. The drug obeyed Beer’s law in the concentration range of 4-36 μg/ml with molar absorptivity of 12.6x 103 l/mol.cm in methanol. The proposed methods were successfully applied for the simultaneous determination of drug in commercial tablet preparations. The results of the analysis have been validated statistically and by recovery...
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Posted by admin on Dec 1, 2010 in |
Calotropis procera (Asclepiadaceae) is an erect, perennial shrub luxuriantly thriving in wastelands. It is commonly distributed in most parts of India and also distributed in Persia, tropical Africa and other tropical countries of the World. The aqueous extract of some parts have laxative property and beneficial in skin diseases, ulcers, enlargement of the spleen, abdominal glands, liver diseases, promotes digestive power and also useful in colics. The milky exudate is useful in skin diseases, tumour and ascitis. It is a very good purgative. Here an attempt has been taken to evaluate the antioxidant activity, CNS depressant activity and also antimicrobial activity of methanolic extract of fresh flowers of C. procera. In result, the methanolic flower extract showed a significant activity against DPPH free radicals and the IC50 value is 64.87µg/ml. On the other hand, CNS depressant activity of the extract was also observed by using In Vivo model. In antimicrobial activity five different fungal species were inhibited by this extract and from the above study the flowers extract showed...
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