Posted by admin on Aug 15, 2010 in |
Rimonabant is an anti-obesity drug which acts as Cannabinoid-1 receptor antagonist. Its main avenue of effect is reduction in appetite. The drug was formulated in the form of Sodium Alginate – Guar gum microspheres following ionotropic gelation method to reduce its dose related side effects. A detailed study of physical and chemical parameters including percentage drug loading and cumulative drug release was carried out and statistically evaluated. Each and every test on all batches was carried out in triplicate. After the experiment the microspheres showed good flow properties with drug entrapment efficiency recorded highest at 71.6%, drug loading results ranged from 12.91-18.20% and the yield percentage was recorded over 90% for all the formulations. The rate of drug release followed Higuchi matrix model equation....
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Posted by admin on Aug 15, 2010 in |
Pimenta dioica commonly known as Allspice was used by early Central American civilizations as a flavoring for chocolate and found to have good anti-microbial action. The current study was therefore carried out to provide requisite pharmacognostic details about the plant. The results of the study could be useful in setting some diagnostic indices for the identification and preparation of a monograph of the...
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Posted by admin on Aug 10, 2010 in |
Colocasia esculenta belonging to family araceae popularly knows as “taro”, is very useful medicinal plant described by Charaka as an anti-inflammatory plant. An experiment was carried out to study the antimicrobial activity of chloroform and methanol extract of Colocasia esculenta plant by agar diffusion method. Zone of inhibition produced by chloroform and methanol extract in dose of 20, 10, 5, 2.5, 1.25, 0.625, 0.3125 mg/ml against some selected strains was measured and compared with standard antibiotics tetracycline in dose of 5, 2.5, 0.625, 0.3125, 0.15625, 0.078072...
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Posted by admin on Aug 1, 2010 in |
AIM: The aim of this study was to analyze the efficacy and safety of concurrent chemotherapy with Cisplatin, Paclitaxel and radiotherapy on survival, functional and quality of life outcomes in locally advanced carcinoma of larynx. MATERIALS & METHODS: From June 2004 to Sep 2006, seventy four inoperable, previously untreated, histopathologically proven, locally advanced patients of carcinoma larynx were planned to be treated with radical EBRT- 56 Gy and concurrent weekly chemotherapy with Cisplatin 30 mg/m2 and 5FU 400 mg/m2 placed in Group A and Group B patients were given RT with concomitant chemotherapy Cisplatin30 mg/m2, Paclitaxel 60 mg/m2 IV weekly up to 4 weeks and after a gap of two weeks all patients were given 20 Gy by reduced field without chemotherapy in both groups . RESULTS: Follow up of patient was done up to September 2008. The duration of follow up was in the range of 16-18 months. Parameters studied were local control, complication, recurrence and mortality. Nearly 79% of patients of Group B had complete response after...
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Posted by admin on Aug 1, 2010 in |
Floating matrix tablets of metformin hydrochloride were developed and evaluated for increase bioavailability by increasing gastric residence time and sustained release of drug on the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. Metformin hydrochloride, an oral antidiabetic having narrow absorption window in the upper part of gastrointestinal tract, was formulated as floating matrix tablet using gas generating agent (potassium bicarbonate) and hydrophilic gelling polymer hydroxyl propyl methyl cellulose (hypromellose) by wet granulation technique. The prepared formulations were evaluated for floating time and in vitro drug release characteristics using modified dissolution method. All formulations possessed good floating properties with total floating time more than 12 hours. Optimization study included 22 factorial design with t50% and t80% as the kinetic parameters. Matrix characterization included photomicrograph, which showed definite entrapment of the drug in the matrix. Formulations with high amount of hypromellose were found to float for longer duration and provide more sustained release of drug. The formulated drug delivery system was found to be independent...
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