Posted by admin on Feb 1, 2010 in |
An attempt has been made to formulate new chewing gum device for ondansetron hydrochloride in the form of tablet. The new drug delivery system was obtained, at room temperature, by direct compression using conventional pharmaceutical equipment. The resulting chewing gum tablets comprise a gum core combined with fillers, antioxidants, coloring agent and plasticizers, which provide smooth appearance and flexibility during storage and chewing. Drug release from a dosage form is the critical step in drug absorption and bioavailability, thus an experimental work has been designed to evaluate the efficiency of this kind of therapeutic system by verifying its capability to release the drug dose and by assessing the delivery of ondansetron hydrochloride for by-passing the hepatic first pass effect. Simple diffusion into the medium causes the release of only a small percentage of the drug contained in the medicated chewing gum, while the delivery of the major part of the dose occurs during mastication. In the present study, an attempt has been made to formulate the chewing gum of...
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Posted by admin on Jan 1, 2010 in |
Phyla nodiflora Linn., Synonym- Lippia nodiflora Rich also known as Jala-pippali is an important herb which can be used medicinally.The aim of the present study is to fractionate several chemical constituents in Phyla nodiflora. Chromatography was used for designing of multi component solvent system for different extracts where, for methanolic extract Hexane: Toluene: Ethyl acetate (2: 1.5: 0.5); for chloroform and petroleum ether Hexane: Ethyl acetate (3:1) were selected. Five different phenolic components were extracted and comparison was done through HPTLC and it was found that in phenolic BuOH extract maximum active constituents were separated....
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Posted by admin on Jan 1, 2010 in |
The present study was aimed to investigate phytochemicals present in the whole plant extract of Dendrophthoe falcata and development of new solvent system for thin layer chromatography of ethanolic (whole plant) extract of medicinal plant Dendrophthoe falcata. The extract showed presence of Carbohydrates, Sterols, Glycosides, Flavonoids and Phenolic compounds. For TLC, new solvent system developed, best result was given by solvent system- Toluene: Ethyle acetate: Formic acid in the ratio of 2.5:1:1. HPTLC report of the extract in same solvent system- Toluene: Ethyle acetate: Formic acid in the ratio of 2.5:1:1 showed the presence of eleven active chemical...
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Posted by admin on Jan 1, 2010 in |
Condensation of o-phenylene diamine with chloro acetic acid gave 2-chloromethyl benzimdazole, which undergoes halide replacement with phenylhydrazines to give the corresponding NN’ disubstituted hydrazines. The synthesized compounds were subjected to microbiological screening and In- vitro anti-inflammatory activity....
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Posted by admin on Jan 1, 2010 in |
Cellular damage arising from free radical is one of the fundamental mechanism underlying a number of human neurodegenerative disorder like diabetes, inflammation, Alzheimer’s disease, autoimmune pathologic and digestive system disorder. Thus antioxidant plays an important role in the treatment of such disease. The present study aims at a comparative evaluation of ethyl acetate, hexane and methanol extract of Vitex leucoxylon Linn. bark for antioxidant activity. Vitex leucoxylon Linn. a medicinal plant of the verbenaceae family, used in traditional medicine for relieving headache and catarrh. HIME was 1.8964 μg/ml after 48 h of incubation. In this study, it was observed that HIME induces a concentration dependent inhibition of HT29 cells, with an IC50 value of 1.8964 μg/ml after 48 h of...
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