Posted by admin on Jun 1, 2010 in |
Barberries are a large group of evergreen shrubs, found in Lalitpur, Allahabad, Bhopal and Haldwani etc. It is an evergreen shrub. Commonly, its fruits are called as berries. This plant is generally use in case of diabetes and mouth ulcer, as a traditional use. Type 2 diabetes mellitus (formerly called NIDDM, type II or adult-onset) is characterized by insulin resistance in peripheral tissue and an insulin secretory defect of the β- cell. This is the most common form of diabetes mellitus and is highly associated with a family history of...
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Posted by admin on Jun 1, 2010 in |
Psoralia corylifolia commonly known as Babchi, Bavachi in Hindi, is a well known herb in Indian system of medicine to treat various disorders including diabetes mellitus without any scientific evidences. Therefore this study was designed to investigate in vivo hypoglycemic and antidiabetic potential of methanolic extract of seeds of Psoralia corylifolia in glucose loaded animals and alloxan induced diabetic animals. In both the models Psoralia corylifolia reduced the blood glucose level when compared to diabetic control group and exert a significant hypoglycemic and antidiabetic activity. However the potency of the herb was less than that of standard drug metformin. Psoralia corylifolia methanolic extract also reversed the body weight in normal and alloxan induced diabetic animals. The results of this study revealed the presence of a significant antidiabetic potential of methanolic extract of Psoralia corylifolia in alloxan induced diabetic rats. On the basis of this further research work is needed to investigate exact mechanism of action and also to isolate the active constituent/s responsible for the...
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Posted by admin on Jun 1, 2010 in |
A simple, accurate, sensitive, reproducible and cost – effective spectrofluorimetric method was developed for the estimation of voglibose in bulk and pharmaceutical formulations. The solvent systems, wavelengths of detection (excitation and emission) were optimized in order to maximize the sensitivity and minimize the cost of analysis for voglibose. Derivatization procedure was employed for analysis. Voglibose showed strong native fluorescence in Methanol having excitation at 282 nm and emission at 345 nm. Effect of different solvents was thoroughly investigated. All parameters like the effect of different solvents, pH, dilutions, reaction time, temperature and effect of excipients were thoroughly investigated. The linear regression equations obtained by least square regression method for Fluorescence Intensity (FI) and concentration in ng/ml. The calibration curve was linear in the range from 100 to 350 ng/ml .The developed method was successfully employed with high degree of precision and accuracy for the estimation of total drug content in commercial tablet formulation of Voglibose (volix).The results of analysis were treated statistically, as per International Conference On Harmonization (ICH)...
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Posted by admin on Jun 1, 2010 in |
Castor (Ricinus communis L, Euphorbiaceous) is needed in the United States to supply caster oil for the hundred of products using this versatile chemurgical raw material. 40-45 thousand tons of castor oil and derivatives are imported each year. Ricinus communis is a common medicinal plant in Ayurveda and is used several part of country for various medicinal properties like the oil of leaf and root are used against various ailments. The oil is useful for skin diseases. Castor oil seeds have tonic effect. The oil is emollient, laxative and it can be used in cases of inflammation of the intestine or dysentery. The present work attempts to summarize the Pharmacognostical characters of the Ricinus communis stem. Ash and extractive values, chemical test, HPTLC, Histological color reactions and fluorescence analysis were also carried out....
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Posted by admin on Jun 1, 2010 in |
PURPOSE OF STUDY: In the present study, an attempt was made to increase therapeutic effectiveness, reduction in dosing frequency and thus improving patient compliance, by developing sustained release matrix tablets of Diclofenac sodium using guar gum as release modifier. METHOD: Six batches of sustained release matrix tablets of Diclofenac sodium was prepared by using different drug: polymer ratios viz. 1:1, 1:1.5, 1:2, 1:2.5, 1:3, and 1:3.5 for guar gum. Guar gum was used as matrix forming material, while microcrystalline cellulose as filler to maintain the tablet weight. The tablets were analyzed to determine their hardness, friability, weight variation, and an In-vitro release of drug was performed in phosphate buffer saline pH 7.4 for twenty four hours. Swelling study was also carried out to study dispersibility of gums at different concentrations. RESULTS: All the physical characters of fabricated tablets were within acceptable limits. Results show that as the concentration of gum increases, swelling index also increased proportionally. Batch G6 shows maximum drug release with sustained rate. CONCLUSIONS: It is clear...
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